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    eif3ha eukaryotic translation initiation factor 3, subunit H, a [ Danio rerio (zebrafish) ]

    Gene ID: 445306, updated on 2-Nov-2024

    Summary

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    Official Symbol
    eif3haprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 3, subunit H, aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040808-19
    See related
    Ensembl:ENSDARG00000102452 AllianceGenome:ZFIN:ZDB-GENE-040808-19
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eif3h; eif3s3; eIF3h-A; fj02c04; wu:fj02c04; zgc:101085
    Summary
    Predicted to enable metallopeptidase activity. Predicted to contribute to translation initiation factor activity. Acts upstream of or within several processes, including lateral line development; regulation of translation; and vasculature development. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic 43S preinitiation complex and eukaryotic translation initiation factor 3 complex. Is expressed in several structures, including gut; heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in breast cancer; prostate cancer; and prostate carcinoma. Orthologous to human EIF3H (eukaryotic translation initiation factor 3 subunit H). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See eif3ha in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (48282321..48400650, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (48340303..48458632, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene collagen triple helix repeat containing 1b Neighboring gene CUB and Sushi multiple domains 3a Neighboring gene uncharacterized LOC137487982 Neighboring gene RAD21 cohesin complex component a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Non-core subunit eIF3h of translation initiation factor eIF3 regulates zebrafish embryonic development. Choudhuri A, et al. Dev Dyn, 2010 Jun. PMID 20503360, Free PMC Article
    2. Analysis of the zebrafish proteome during embryonic development. Lucitt MB, et al. Mol Cell Proteomics, 2008 May. PMID 18212345, Free PMC Article
    3. Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis. Choudhuri A, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716667, Free PMC Article
    4. Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish. Gebauer JM, et al. Matrix Biol, 2016 Jan. PMID 26235539
    5. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate the role of a noncore eIF3 subunit eif3ha in modulating a specific developmental program by regulating translation of defined transcripts.
      Title: Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis.
    2. Non-core subunit eif3h of translation intiation factor eIF3 regulates zebrafish embryonic development.
      Title: Non-core subunit eIF3h of translation initiation factor eIF3 regulates zebrafish embryonic development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lateral line development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit H-A
    Names
    eIF-3-gamma-A
    eukaryotic translation initiation factor 3, subunit 3 (gamma)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003763.2 → NP_001003763.1  eukaryotic translation initiation factor 3 subunit H-A

      See identical proteins and their annotated locations for NP_001003763.1

      Status: VALIDATED

      Source sequence(s)
      BI473261, EH509704, FP015828
      UniProtKB/Swiss-Prot
      Q6AXJ2
      Related
      ENSDARP00000129950.1, ENSDART00000159372.2
      Conserved Domains (1) summary
      cd08065
      Location:20 → 283
      MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      48282321..48400650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXJ2.1 GenPept UniProtKB/Swiss-Prot:Q6AXJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.