rer1 retention in endoplasmic reticulum sorting receptor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rer1provided by ZNC
Official Full Name: retention in endoplasmic reticulum sorting receptor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1494
See related: Ensembl:ENSDARG00000012747 AllianceGenome:ZFIN:ZDB-GENE-040426-1494
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:65968
Summary: Acts upstream of or within cilium assembly. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in Kupffer's vesicle; lateral line; olfactory pit; otic vesicle; and pronephros. Orthologous to human RER1 (retention in endoplasmic reticulum sorting receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (48942540..48959608)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (48953707..48970841)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rer1p depletion reduced ciliary length and function by increasing gamma-secretase complex assembly and activity and, consequently, enhancing Notch signaling as well as reducing Foxj1a expression.
Title: Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein retention in ER lumen	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein RER1

Names: RER1 retention in endoplasmic reticulum 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.