gnl3 G protein nucleolar 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gnl3provided by ZNC
Official Full Name: G protein nucleolar 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-616
See related: Ensembl:ENSDARG00000006219 AllianceGenome:ZFIN:ZDB-GENE-030131-616
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nstm; id:ibd2914; wu:fb38a04; wu:fc55d07; zgc:123093
Summary: Predicted to enable GTP binding activity. Acts upstream of or within several processes, including exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); neural retina development; and regulation of exit from mitosis. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in head; immature eye; midbrain; and somite. Orthologous to human GNL3 (G protein nucleolar 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (3959529..3971029)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (3940142..3951642)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish.
Title: The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fe01a08.x1 (e-PCR)
- UniSTS:195897

fe11f02.y1 (e-PCR)
- UniSTS:196073

AI437119 (e-PCR)
- UniSTS:206589

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural retina development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: guanine nucleotide-binding protein-like 3

Names: guanine nucleotide binding protein-like 3 (nucleolar); nucleostemin; nucleostemin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002297.1 → NP_001002297.1 guanine nucleotide-binding protein-like 3

See identical proteins and their annotated locations for NP_001002297.1

Status: PROVISIONAL

Source sequence(s)

AY648717

UniProtKB/Swiss-Prot

Q6DI18, Q6DRP2

Related

ENSDARP00000109517.2, ENSDART00000122953.3

Conserved Domains (3) summary

cd04178
Location:144 → 316

Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases

TIGR03596
Location:128 → 411

GTPase_YlqF; ribosome biogenesis GTP-binding protein YlqF

pfam08701
Location:17 → 85

GN3L_Grn1; GNL3L/Grn1 putative GTPase