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    meis2b Meis homeobox 2b [ Danio rerio (zebrafish) ]

    Gene ID: 30066, updated on 2-Nov-2024

    Summary

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    Official Symbol
    meis2bprovided by ZNC
    Official Full Name
    Meis homeobox 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000210-23
    See related
    Ensembl:ENSDARG00000077840 AllianceGenome:ZFIN:ZDB-GENE-000210-23
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    meis2; meis2.1
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within cardiac atrium morphogenesis and heart looping. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural keel; cardiovascular system; nervous system; neural plate; and optic vesicle. Human ortholog(s) of this gene implicated in cleft palate; cleft palate, cardiac defects, and intellectual disabillity; learning disability; open-angle glaucoma; and orofacial cleft. Orthologous to human MEIS2 (Meis homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See meis2b in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (10099109..10118728, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (10111869..10133202, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene transfer RNA leucine (anticodon CAA) Neighboring gene zinc finger protein 770 Neighboring gene potassium channel, subfamily K, member 10a Neighboring gene si:dkey-63b1.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning and developmental expression of a zebrafish meis2 homeobox gene. Zerucha T, et al. Mech Dev, 2001 Apr. PMID 11287203
    2. A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Paige SL, et al. Cell, 2012 Sep 28. PMID 22981225, Free PMC Article
    3. Phylogeny of the teashirt-related zinc finger (tshz) gene family and analysis of the developmental expression of tshz2 and tshz3b in the zebrafish. Santos JS, et al. Dev Dyn, 2010 Mar. PMID 20108322
    4. Constructing the hindbrain: insights from the zebrafish. Moens CB, et al. Dev Dyn, 2002 May. PMID 11984869
    5. meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye. Bessa J, et al. Development, 2008 Mar. PMID 18216175

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac atrium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Meis2b
    Names
    myeloid ecotropic viral integration site 2.1
    myeloid ecotropic viral integration site 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130910.1 → NP_570985.1  homeobox protein Meis2b

      See identical proteins and their annotated locations for NP_570985.1

      Status: PROVISIONAL

      Source sequence(s)
      AF170065
      UniProtKB/TrEMBL
      Q9PTM7
      Related
      ENSDARP00000034815.5, ENSDART00000033976.7
      Conserved Domains (2) summary
      pfam05920
      Location:293 → 332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:112 → 195
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      10099109..10118728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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