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    pgap2 post-GPI attachment to proteins 2 [ Danio rerio (zebrafish) ]

    Gene ID: 541417, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pgap2provided by ZNC
    Official Full Name
    post-GPI attachment to proteins 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-119
    See related
    Ensembl:ENSDARG00000044596 AllianceGenome:ZFIN:ZDB-GENE-050320-119
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    frag1; wu:fc51g11; zgc:101568
    Summary
    Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 3. Orthologous to human PGAP2 (post-GPI attachment to proteins 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pgap2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (30973692..30994580, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (30935182..30957909, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene stromal interaction molecule 1b Neighboring gene uncharacterized LOC101886778 Neighboring gene ras homolog family member Gb Neighboring gene nuclear cap binding subunit 3 Neighboring gene RAP1 GTPase activating protein 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    post-GPI attachment to proteins factor 2
    Names
    FGF receptor-activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013544.2 → NP_001013562.1  post-GPI attachment to proteins factor 2

      See identical proteins and their annotated locations for NP_001013562.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090817
      UniProtKB/Swiss-Prot
      Q5BL33
      Related
      ENSDART00000100926.5
      Conserved Domains (1) summary
      pfam10277
      Location:19 → 216
      Frag1; Frag1/DRAM/Sfk1 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      30973692..30994580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161301.5 → XP_005161358.1  post-GPI attachment to proteins factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B8B3, G1K2N7
      Related
      ENSDARP00000065502.4, ENSDART00000065503.6
      Conserved Domains (1) summary
      pfam10277
      Location:19 → 241
      Frag1; Frag1/DRAM/Sfk1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BL33.1 GenPept UniProtKB/Swiss-Prot:Q5BL33

    Gene LinkOut

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