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    rit1 Ras-like without CAAX 1 [ Danio rerio (zebrafish) ]

    Gene ID: 793942, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rit1provided by ZNC
    Official Full Name
    Ras-like without CAAX 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-329
    See related
    Ensembl:ENSDARG00000069150 AllianceGenome:ZFIN:ZDB-GENE-070912-329
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-93a2.3
    Summary
    Predicted to enable GTPase activity; calmodulin binding activity; and guanyl ribonucleotide binding activity. Acts upstream of or within embryonic viscerocranium morphogenesis and heart development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 8; RASopathy; and hepatocellular carcinoma. Orthologous to several human genes including RIT1 (Ras like without CAAX 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See rit1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (24039894..24066703)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (24455671..24480867)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene SMAD family member 10a Neighboring gene synaptotagmin XIa Neighboring gene uncharacterized LOC137488518 Neighboring gene peroxisomal biogenesis factor 11 beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome. Aoki Y, et al. Am J Hum Genet, 2013 Jul 11. PMID 23791108, Free PMC Article
    2. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Zhang C, et al. Fish Shellfish Immunol, 2019 Nov. PMID 31546038
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein Rit1
    NP_001122253.1
    XP_021323817.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128781.1 → NP_001122253.1  GTP-binding protein Rit1

      See identical proteins and their annotated locations for NP_001122253.1

      Status: PROVISIONAL

      Source sequence(s)
      BC163608
      UniProtKB/TrEMBL
      B3DJU3, B3DJU4, F6NWD1
      Related
      ENSDARP00000091195.3, ENSDART00000100422.4
      Conserved Domains (2) summary
      smart00010
      Location:12 → 177
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cl21455
      Location:12 → 180
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      24039894..24066703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468142.2 → XP_021323817.1  GTP-binding protein Rit1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9P1Y7
      Conserved Domains (1) summary
      cl21455
      Location:1 → 150
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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