U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    flna filamin A, alpha (actin binding protein 280) [ Danio rerio (zebrafish) ]

    Gene ID: 562529, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    flnaprovided by ZNC
    Official Full Name
    filamin A, alpha (actin binding protein 280)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2145
    See related
    Ensembl:ENSDARG00000074201 AllianceGenome:ZFIN:ZDB-GENE-030131-2145
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb98b06; fd09g03; wu:fb98b06; wu:fd09g03; wu:fd49a06
    Summary
    Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including determination of heart left/right asymmetry; intestinal motility; and peristalsis. Predicted to be located in intracellular non-membrane-bounded organelle. Is expressed in brain; gut; head; and intestine. Human ortholog(s) of this gene implicated in X-linked chronic idiopathic intestinal pseudo-obstruction; bone development disease (multiple); heart valve disease (multiple); periventricular nodular heterotopia; and terminal osseous dysplasia. Orthologous to human FLNA (filamin A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See flna in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (19759153..19809023)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (19827621..19882680)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ribosomal protein L10 Neighboring gene si:dkey-93l1.9 Neighboring gene emerin

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The long Filamin-A isoform is required for intestinal development and motility: implications for chronic intestinal pseudo-obstruction. Zada A, et al. Hum Mol Genet, 2023 Jan 1. PMID 35981053, Free PMC Article
    2. Filamin acts as a key regulator in epithelial defence against transformed cells. Kajita M, et al. Nat Commun, 2014 Jul 31. PMID 25079702
    3. Identification of novel candidate genes in heterotaxy syndrome patients with congenital heart diseases by whole exome sequencing. Liang S, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Dec 1. PMID 32738303
    4. Efficient targeted integration directed by short homology in zebrafish and mammalian cells. Wierson WA, et al. Elife, 2020 May 15. PMID 32412410, Free PMC Article
    5. Attributing effects of aqueous C60 nano-aggregates to tetrahydrofuran decomposition products in larval zebrafish by assessment of gene expression. Henry TB, et al. Environ Health Perspect, 2007 Jul. PMID 17637923, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within determination of heart left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intestinal motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peristalsis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    filamin-A

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      19759153..19809023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296770.4 → XP_009295045.2  filamin-A isoform X1

      Related
      ENSDARP00000113808.1, ENSDART00000135820.3

    2. XM_017353690.3 → XP_017209179.2  filamin-A isoform X3

    3. XM_009296771.4 → XP_009295046.2  filamin-A isoform X2

    4. XM_068216891.1 → XP_068072992.1  filamin-A isoform X4

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395142.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      87147..137035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473622.2 → XP_021329297.2  filamin-A isoform X1

    2. XM_021473624.2 → XP_021329299.2  filamin-A isoform X3

    3. XM_021473623.2 → XP_021329298.2  filamin-A isoform X2

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395361.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      303592..353462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474523.2 → XP_021330198.2  filamin-A isoform X1

    2. XM_021474525.2 → XP_021330200.2  filamin-A isoform X3

    3. XM_021474524.2 → XP_021330199.2  filamin-A isoform X2

    4. XM_068219394.1 → XP_068075495.1  filamin-A isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.