gh1 growth hormone 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gh1provided by ZNC
Official Full Name: growth hormone 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030725-2
See related: Ensembl:ENSDARG00000038185 AllianceGenome:ZFIN:ZDB-GENE-030725-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ghl
Summary: Enables growth hormone activity and growth hormone receptor binding activity. Acts upstream of or within adipose tissue development and positive regulation of lipid catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including adenohypophyseal placode; bone tissue; hematopoietic multipotent progenitor cell; hypophysis; and male organism. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including GH1 (growth hormone 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (22327741..22332913)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (22197193..22202365)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reproductive tests showed that double transgenic males did not differ from non-transgenics. It is possible that GHR excess in the muscle tissues of double transgenics may have contributed to lower circulating GH levels and thus reduced the negative effects of this hormone with respect to reproduction.
Title: Reproductive parameters of double transgenic zebrafish (Danio rerio) males overexpressing both the growth hormone (GH) and its receptor (GHR).
that concomitant overexpression of GH and GHR resulted in a strong decrease of the somatotrophic axis intracellular signaling by diminishing its principal transcription factor signal transducer and activator of transcription 5.1.
Title: Effects of Double Transgenesis of Somatotrophic Axis (GH/GHR) on Skeletal Muscle Growth of Zebrafish (Danio rerio).
Effects of somatotrophic axis (GH/GHR) double transgenesis on structural and molecular aspects of the zebrafish immune system
Title: Effects of somatotrophic axis (GH/GHR) double transgenesis on structural and molecular aspects of the zebrafish immune system.
The zebrafish gh1 mutant, vizzini, exhibits decreased somatic growth, increased adipose tissue accumulation, and disrupted adipose plasticity after nutrient deprivation.
Title: Dwarfism and increased adiposity in the gh1 mutant zebrafish vizzini.
tbx5 knockdown causes a pseudo GH deficiency in zebrafish during early embryonic stages, and supplementation of exogenous GH can partially restore dysmorphogenesis, apoptosis, cell growth inhibition, and abnormal cardiomyogenesis
Title: The paracrine effect of exogenous growth hormone alleviates dysmorphogenesis caused by tbx5 deficiency in zebrafish (Danio rerio) embryos.
Inhibition of GH specific translation did not lead to any discernable morphological changes within 10 days post fertilization.
Title: The effects of the members of growth hormone family knockdown in zebrafish development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables growth hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables growth hormone receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in growth hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: somatotropin

Names: gh

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020492.2 → NP_001018328.2 somatotropin precursor

See identical proteins and their annotated locations for NP_001018328.2

Status: PROVISIONAL

Source sequence(s)

BC116501

UniProtKB/TrEMBL

A0A8M1N5U3, Q1JQ34

Related

ENSDARP00000055674.4, ENSDART00000055675.5

Conserved Domains (1) summary

cd10285
Location:28 → 208

somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones