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    sulf1 sulfatase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 337298, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sulf1provided by ZNC
    Official Full Name
    sulfatase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9242
    See related
    Ensembl:ENSDARG00000038428 AllianceGenome:ZFIN:ZDB-GENE-030131-9242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fk14e08
    Summary
    Predicted to enable N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Acts upstream of or within with a positive effect on epithelial structure maintenance. Acts upstream of or within several processes, including neuromast deposition; regulation of myotome development; and vasculogenesis. Predicted to be located in Golgi stack. Predicted to be active in cell surface; endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; head; hypochord; and somite. Orthologous to human SULF1 (sulfatase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sulf1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (19518559..19587535)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (19374157..19443110)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 Neighboring gene zgc:162928 Neighboring gene solute carrier organic anion transporter family member 5A1 Neighboring gene cysteine-serine-rich nuclear protein 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2. Gorsi B, et al. Dev Dyn, 2010 Dec. PMID 20981828
    2. Sulf1 modulates BMP signaling and is required for somite morphogenesis and development of the horizontal myoseptum. Meyers JR, et al. Dev Biol, 2013 Jun 15. PMID 23583585
    3. In vivo analysis of choroid plexus morphogenesis in zebrafish. García-Lecea M, et al. PLoS One, 2008 Sep 1. PMID 18769618, Free PMC Article
    4. Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish. Schenk H, et al. Biomed Res Int, 2019. PMID 31428635, Free PMC Article
    5. Co-option of the PRDM14-CBFA2T complex from motor neurons to pluripotent cells during vertebrate evolution. Kawaguchi M, et al. Development, 2019 Jan 28. PMID 30630825

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish.
      Title: Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish.
    2. lack of SULF1 expression downregulates VEGFA-mediated arterial marker expression, confirming that Sulf1 mediates arterial specification by regulating VegfA165 activity.
      Title: The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity.
    3. Sulf1 triggers Shh signaling activity to establish and, later on, modify the spatial arrangement of gene expression in ventral neural progenitors
      Title: Dynamics of sonic hedgehog signaling in the ventral spinal cord are controlled by intrinsic changes in source cells requiring sulfatase 1.
    4. Data indicate that sulf1 plays a crucial role in modulating both BMP and FGF signaling.
      Title: Sulf1 modulates BMP signaling and is required for somite morphogenesis and development of the horizontal myoseptum.
    5. Zebrafish sulf1 and sulf2a are broadly expressed in the central nervous system (CNS) and non-neuronal tissue including heart, somite boundaries, olfactory system, and otic vesicle.
      Title: Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfuric ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood circulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect epithelial structure maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glomerular basement membrane development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuromast deposition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of developmental pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of myotome development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    extracellular sulfatase Sulf-1
    Names
    sulfatase FP1c
    NP_001003846.1
    XP_068073137.1
    XP_068073138.1
    XP_068073139.1
    XP_068073140.1
    XP_068073141.1
    XP_068073142.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003846.2 → NP_001003846.1  extracellular sulfatase Sulf-1 precursor

      See identical proteins and their annotated locations for NP_001003846.1

      Status: VALIDATED

      Source sequence(s)
      CR382282, CR385071
      UniProtKB/TrEMBL
      A0A8M1N1N4, Q6EFA1
      Related
      ENSDARP00000056080.2, ENSDART00000056081.4
      Conserved Domains (4) summary
      COG3119
      Location:41 → 392
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      pfam12548
      Location:540 → 675
      DUF3740; Sulfatase protein
      cd16147
      Location:41 → 383
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      cl23718
      Location:770 → 819
      ALP_like; alkaline phosphatases and sulfatases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      19518559..19587535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217039.1 → XP_068073140.1  extracellular sulfatase Sulf-1 isoform X3

      Related
      ENSDARP00000056079.3, ENSDART00000056080.6

    2. XM_068217040.1 → XP_068073141.1  extracellular sulfatase Sulf-1 isoform X4

      Related
      ENSDARP00000153504.1, ENSDART00000191042.1

    3. XM_068217041.1 → XP_068073142.1  extracellular sulfatase Sulf-1 isoform X5

      Related
      ENSDARP00000013515.7, ENSDART00000027022.8

    4. XM_068217038.1 → XP_068073139.1  extracellular sulfatase Sulf-1 isoform X2

    5. XM_068217036.1 → XP_068073137.1  extracellular sulfatase Sulf-1 isoform X1

      Related
      ENSDARP00000153732.1, ENSDART00000180782.1

    6. XM_068217037.1 → XP_068073138.1  extracellular sulfatase Sulf-1 isoform X1

    Nucleotide Protein
    Heading Accession and Version

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