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    Entrep3 endosomal transmembrane epsin interactor 3 [ Mus musculus (house mouse) ]

    Gene ID: 68521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Entrep3provided by MGI
    Official Full Name
    endosomal transmembrane epsin interactor 3provided by MGI
    Primary source
    MGI:MGI:1915771
    See related
    Ensembl:ENSMUSG00000032657 AllianceGenome:MGI:1915771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam189b; 1110013L07Rik
    Summary
    Predicted to enable WW domain binding activity. Predicted to be located in membrane. Orthologous to human ENTREP3 (endosomal transmembrane epsin interactor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 29.1), limb E14.5 (RPKM 19.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Entrep3 in Genome Data Viewer
    Location:
    3 F1; 3 39.01 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89089996..89096598)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89183143..89189291)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene pyruvate kinase liver and red blood cell Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 3 Neighboring gene predicted gene, 45927 Neighboring gene CDC-like kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2079 Neighboring gene secretory carrier membrane protein 3 Neighboring gene predicted gene 16069 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88994426-88994609 Neighboring gene STARR-positive B cell enhancer ABC_E275 Neighboring gene STARR-positive B cell enhancer ABC_E10196 Neighboring gene predicted gene, 23269 Neighboring gene glucosylceramidase beta 1 Neighboring gene metaxin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ectopic overexpression of COTE1 promotes cellular invasion of hepatocellular carcinoma. Zhang H, et al. Asian Pac J Cancer Prev, 2012. PMID 23317259
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables WW domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein ENTREP3
    Names
    family with sequence similarity 189, member B
    protein FAM189B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014995.2 → NP_001014995.1  protein ENTREP3 isoform 1

      See identical proteins and their annotated locations for NP_001014995.1

      Status: VALIDATED

      Source sequence(s)
      AC161600, BC088990
      Consensus CDS
      CCDS17492.1
      UniProtKB/Swiss-Prot
      Q5HZJ5
      UniProtKB/TrEMBL
      E9Q6P6
      Related
      ENSMUSP00000039261.7, ENSMUST00000041913.13
      Conserved Domains (1) summary
      pfam04103
      Location:36 → 196
      CD20; CD20-like family

    2. NM_001355760.1 → NP_001342689.1  protein ENTREP3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161600, BC085505
      UniProtKB/TrEMBL
      E9Q6P6
      Conserved Domains (1) summary
      pfam04103
      Location:1 → 90
      CD20; CD20-like family

    3. NM_001355765.1 → NP_001342694.1  protein ENTREP3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161600, BC068123

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89089996..89096598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163265.1 → XP_036019158.1  protein ENTREP3 isoform X1

      UniProtKB/Swiss-Prot
      Q5HZJ5
      UniProtKB/TrEMBL
      E9Q6P6
      Conserved Domains (1) summary
      pfam04103
      Location:36 → 196
      CD20; CD20-like family

    2. XM_006501981.3 → XP_006502044.1  protein ENTREP3 isoform X7

    3. XM_030252778.2 → XP_030108638.1  protein ENTREP3 isoform X5

      UniProtKB/TrEMBL
      E9Q6P6
      Conserved Domains (1) summary
      pfam04103
      Location:1 → 90
      CD20; CD20-like family

    4. XM_030252777.2 → XP_030108637.1  protein ENTREP3 isoform X6

      UniProtKB/TrEMBL
      E9Q6P6
      Conserved Domains (1) summary
      pfam04103
      Location:1 → 90
      CD20; CD20-like family

    5. XM_006501977.5 → XP_006502040.1  protein ENTREP3 isoform X2

      See identical proteins and their annotated locations for XP_006502040.1

      UniProtKB/TrEMBL
      E9Q6P6
      Related
      ENSMUSP00000113579.2, ENSMUST00000119707.2
      Conserved Domains (1) summary
      pfam04103
      Location:36 → 196
      CD20; CD20-like family

    6. XM_006501978.5 → XP_006502041.1  protein ENTREP3 isoform X3

      UniProtKB/TrEMBL
      E9Q6C9, E9Q6P6
      Related
      ENSMUSP00000113706.2, ENSMUST00000117278.8
      Conserved Domains (1) summary
      pfam04103
      Location:36 → 177
      CD20; CD20-like family

    7. XM_030252776.2 → XP_030108636.1  protein ENTREP3 isoform X4

      UniProtKB/TrEMBL
      E9Q6P6
      Conserved Domains (1) summary
      pfam04103
      Location:36 → 177
      CD20; CD20-like family

    8. XM_036163266.1 → XP_036019159.1  protein ENTREP3 isoform X7

    RNA

    1. XR_001783738.3 RNA Sequence

      Related
      ENSMUST00000147696.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZJ5.1 GenPept UniProtKB/Swiss-Prot:Q5HZJ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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