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    RTC3 Rtc3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856487, updated on 1-Aug-2024

    Summary

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    Gene symbol
    RTC3
    Gene description
    Rtc3p
    Primary source
    FungiDB:YHR087W
    Locus tag
    YHR087W
    See related
    SGD:S000001129; AllianceGenome:SGD:S000001129; VEuPathDB:YHR087W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HGI1
    Summary
    Involved in RNA metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RTC3 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (280820..281155)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Nam8p Neighboring gene uncharacterized protein Neighboring gene rRNA-binding ribosome biosynthesis protein RPF1 Neighboring gene H/ACA snoRNP pseudouridylase subunit GAR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular response of Saccharomyces cerevisiae wine and laboratory strains to high sugar stress conditions. Jiménez-Martí E, et al. Int J Food Microbiol, 2011 Jan 31. PMID 21247650
    2. Genetic manipulation of HSP26 and YHR087W stress genes may improve fermentative behaviour in wine yeasts under vinification conditions. Jiménez-Martí E, et al. Int J Food Microbiol, 2009 Mar 31. PMID 19217680
    3. Phylogeny, sequence conservation, and functional complementation of the SBDS protein family. Boocock GR, et al. Genomics, 2006 Jun. PMID 16529906
    4. Structural and mutational analysis of the SBDS protein family. Insight into the leukemia-associated Shwachman-Diamond Syndrome. Shammas C, et al. J Biol Chem, 2005 May 13. PMID 15701631
    5. Dissection of the elements of osmotic stress response transcription factor Hot1 involved in the interaction with MAPK Hog1 and in the activation of transcription. Gomar-Alba M, et al. Biochim Biophys Acta, 2013 Oct. PMID 23916462

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YHR087W gene is highly expressed in the presence of high glucose concentrations. Deletion mutants present lower levels of several Hsp proteins.
      Title: Molecular response of Saccharomyces cerevisiae wine and laboratory strains to high sugar stress conditions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rtc3p
    NP_011955.1
    • hypothetical protein involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog is SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      280820..281155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179217.1 → NP_011955.1  TPA: Rtc3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011955.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL39, P38804
      UniProtKB/TrEMBL
      A6ZSZ7, B3LSK5, C7GWV1, C8Z9N2, G2WFG2, N1P129
      Conserved Domains (1) summary
      pfam01172
      Location:6 → 95
      SBDS; Shwachman-Bodian-Diamond syndrome (SBDS) protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38804.1

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