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    WSC4 Wsc4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856357, updated on 17-May-2024

    Summary

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    Gene symbol
    WSC4
    Gene description
    Wsc4p
    Primary source
    FungiDB:YHL028W
    Locus tag
    YHL028W
    See related
    SGD:S000001020; AllianceGenome:SGD:S000001020; VEuPathDB:YHL028W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YFW1; YHC8
    Summary
    Enables protein transmembrane transporter activity. Involved in protein targeting to ER; protein targeting to membrane; and response to heat. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See WSC4 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (48763..50580)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ecm29p Neighboring gene Oca5p Neighboring gene alkaline-responsive transcriptional regulator RIM101 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of YHC8, a member of the TSR1 gene family, reveals its direct involvement in yeast protein translocation. Mamoun CB, et al. J Biol Chem, 1999 Apr 16. PMID 10196219
    2. The TSR1 gene of Yarrowia lipolytica is involved in the signal recognition particle-dependent translocation pathway of secretory proteins. Mamoun CB, et al. J Biol Chem, 1996 Sep 27. PMID 8798620
    3. Suppression of Escherichia coli alkB mutants by Saccharomyces cerevisiae genes. Wei YF, et al. J Bacteriol, 1995 Sep. PMID 7665478, Free PMC Article
    4. Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae. Lodder AL, et al. Genetics, 1999 Aug. PMID 10430578, Free PMC Article
    5. The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Nanduri J, et al. Mol Cell, 2001 Aug. PMID 11545731

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to ER IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to heat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Wsc4p
    NP_011835.1
    • Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      48763..50580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179108.1 → NP_011835.1  TPA: Wsc4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011835.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKU0, P38739
      UniProtKB/TrEMBL
      A0A8H4C1R9, B3LS91, B5VJQ1, C8ZA36, N1P2Q4
      Conserved Domains (1) summary
      smart00321
      Location:25 → 109
      WSC; present in yeast cell wall integrity and stress response component proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38739.1

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