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    hri2 eIF2 alpha kinase Hri2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541943, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hri2
    Official Full Name
    eIF2 alpha kinase Hri2
    Primary source
    PomBase:SPAC222.07c
    Locus tag
    SPOM_SPAC222.07C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See hri2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (954279..956610, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ino80 complex subunit Ies6 Neighboring gene GTPase mss1 Neighboring gene ncRNA Neighboring gene nuclear HMG-like acidic protein Mak16 Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene glutamine aminotransferase subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New roles of the fission yeast eIF2α kinases Hri1 and Gcn2 in response to nutritional stress. Martín R, et al. J Cell Sci, 2013 Jul 15. PMID 23687372
    2. Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses. Zhan K, et al. Mol Cell Biol, 2002 Oct. PMID 12242291, Free PMC Article
    3. Cmk2 kinase is essential for survival in arsenite by modulating translation together with RACK1 orthologue Cpc2 in Schizosaccharomyces pombe. Sanchez-Marinas M, et al. Free Radic Biol Med, 2018 Dec. PMID 30236788
    4. Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast. Tarumoto Y, et al. J Biol Chem, 2013 Jun 28. PMID 23671279, Free PMC Article
    5. Role of mitogen-activated protein kinase Sty1 in regulation of eukaryotic initiation factor 2alpha kinases in response to environmental stress in Schizosaccharomyces pombe. Berlanga JJ, et al. Eukaryot Cell, 2010 Jan. PMID 19880757, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings point to a regulatory coordination between the Sty1 MAPK and Hri1/Hri2 eIF2alpha kinase pathways for a particular range of stress responses.
      Title: Role of mitogen-activated protein kinase Sty1 in regulation of eukaryotic initiation factor 2alpha kinases in response to environmental stress in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1 to G0 transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytoplasmic translational initiation in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cytoplasmic translational initiation in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signaling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eIF2 alpha kinase Hri2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      954279..956610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018543.3 → NP_593146.1  eIF2 alpha kinase Hri2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593146.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UTE5
      Conserved Domains (2) summary
      smart00220
      Location:171 → 583
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13996
      Location:164 → 585
      STKc_EIF2AK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase
    Nucleotide Protein
    Heading Accession and Version

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