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    tel1 ATM checkpoint kinase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539209, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tel1
    Official Full Name
    ATM checkpoint kinase
    Primary source
    PomBase:SPCC23B6.03c
    Locus tag
    SPOM_SPCC23B6.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See tel1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1268573..1277541, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribosome large subunit export factor Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene sec14 family protein Neighboring gene DNA replication factor A subunit Ssb3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the intact ATM/Tel1 kinase. Wang X, et al. Nat Commun, 2016 May 27. PMID 27229179, Free PMC Article
    2. Physical basis for long-distance communication along meiotic chromosomes. Fowler KR, et al. Proc Natl Acad Sci U S A, 2018 Oct 2. PMID 30217891, Free PMC Article
    3. [Telomere maintenance by DNA damage sensor kinases, ATM and ATR]. Yamazaki H, et al. Seikagaku, 2014 Dec. PMID 25675824
    4. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues. Naito T, et al. Nat Genet, 1998 Oct. PMID 9771717
    5. A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast. Subramanian L, et al. PLoS Genet, 2010 Feb 5. PMID 20140190, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structure suggests that ataxia-telangiectasia mutated protein (ATM/Tel1) dimer interface and the consecutive HEAT repeats inhibit the binding of kinase substrates and regulators by steric hindrance.
      Title: Structure of the intact ATM/Tel1 kinase.
    2. It is a DNA damage sensor kinases and plays a roll in telomere maintenance.
      Title: [Telomere maintenance by DNA damage sensor kinases, ATM and ATR].
    3. Tel1(ATM)/Rad3(ATR)-dependent Ccq1 Thr93 phosphorylation is a critical regulator of telomere maintenance in fission yeast.
      Title: Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.
    4. The N-terminus of Nbs1 contributes to the recruitment of Rad3(ATR)-Rad26(ATRIP) to telomeres.
      Title: A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast.
    5. Tel1 and Rad3 are required for both protection of telomeres against recombination and promotion of telomerase recruitment.
      Title: Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment.
    6. Recombination-based telomere maintenance is dependent on Tel1 and Rap1 and inhibited by telomerase, Taz1, and Ku.
      Title: Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of initiation of premeiotic DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spatial regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome, telomeric repeat region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATM checkpoint kinase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1268573..1277541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023116.3 → NP_588126.1  ATM checkpoint kinase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588126.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74630
      Conserved Domains (4) summary
      COG5032
      Location:289 → 2812
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05171
      Location:2446 → 2722
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
      pfam02260
      Location:2781 → 2811
      FATC; FATC domain
      pfam11640
      Location:6 → 151
      TAN; Telomere-length maintenance and DNA damage repair
    Nucleotide Protein
    Heading Accession and Version

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