SOD2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SOD2
Primary source: SGD:S000001050
Locus tag: YHR008C
See related: AllianceGenome:SGD:S000001050; FungiDB:YHR008C; VEuPathDB:YHR008C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables superoxide dismutase activity. Involved in reactive oxygen species metabolic process. Located in mitochondrial matrix. Used to study Alzheimer's disease; Parkinson's disease; and cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (122889..123590, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial superoxide dismutase Sod2 suppresses nuclear genome instability during oxidative stress.
Title: Mitochondrial superoxide dismutase Sod2 suppresses nuclear genome instability during oxidative stress.
Repression of SOD2 prevents ethanol-induced relocalization of yeast hydrogen peroxide-sensing transcription factor Yap1p, one of the key stress resistance proteins. Analysis of the ethanol sensitivities of the cells lacking Sod2p, Yap1p, or both indicated that the two proteins act in the same pathway.
Title: Mitochondrial Superoxide Dismutase and Yap1p Act as a Signaling Module Contributing to Ethanol Tolerance of the Yeast Saccharomyces cerevisiae.
Results provide evidence that the mutation I91T brings damage to Sod2 activity, con fi rming further the role of the yeast S. cerevisiae as a model to study disease mechanisms related to oxidative stress.
Title: In Vivo Characterization of I91T Sod2 Polymorphism of Saccharomyces cerevisiae.
surface-potential distribution of SOD2 revealed a conserved positively charged electrostatic zone in the proximity of the active site
Title: Structures of native and Fe-substituted SOD2 from Saccharomyces cerevisiae.
Data find that misincorporation of iron into yeast Sod2p does not correlate with significant changes in the average oxidation state or coordination chemistry of bulk mitochondrial iron.
Title: The interaction of mitochondrial iron with manganese superoxide dismutase.
Inactivation of SOD1 and SOD2 modifies response to S-nitrosoglutathione-induced stress.
Title: Inactivation of genes encoding superoxide dismutase modifies yeast response to S-nitrosoglutathione-induced stress.
sod 2 Delta and sod 1 Deltasod 2 Delta demonstrated the highest levels of GSH in the control, suggesting that pathways which include GSH protect these double mutants against oxidative stress
Title: Adaptative response to enhanced basal oxidative damage in sod mutants from Saccharomyces cerevisiae.
the insertion of manganese into eukaryotic SOD2 molecules is driven by the protein unfolding process associated with mitochondrial import
Title: Manganese activation of superoxide dismutase 2 in the mitochondria of Saccharomyces cerevisiae.
neither MnSOD nor CuZnSOD is required for protecting the majority of mitochondrial proteins from oxidative damage during early phases of growth
Title: Mitochondrial protein oxidation in yeast mutants lacking manganese-(MnSOD) or copper- and zinc-containing superoxide dismutase (CuZnSOD): evidence that MnSOD and CuZnSOD have both unique and overlapping functions in protecting mitochondrial proteins from oxidative damage.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in removal of superoxide radicals	IEA Inferred from Electronic Annotation more info
involved_in superoxide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: superoxide dismutase SOD2

NP_011872.1

EC 1.15.1.1

Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

122889..123590 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179138.1 → NP_011872.1 TPA: superoxide dismutase SOD2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011872.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DKV3, P00447

UniProtKB/TrEMBL

A6ZSR2, B3LSC9, B5VJT4, C7GMQ3, C8ZA75, G2WF76, N1P9K8, S4VIJ3, S4VPL7

Conserved Domains (1) summary

COG0605
Location:25 → 233

SodA; Superoxide dismutase [Inorganic ion transport and metabolism]