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    top3 DNA topoisomerase III [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539881, updated on 18-Sep-2024

    Summary

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    Official Symbol
    top3
    Official Full Name
    DNA topoisomerase III
    Primary source
    PomBase:SPBC16G5.12c
    Locus tag
    SPOM_SPBC16G5.12C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See top3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003423.3 (4233868..4236269, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene serine carboxypeptidase Neighboring gene ncRNA Neighboring gene exosome subunit Rrp42 Neighboring gene ncRNA Neighboring gene BAG family molecular chaperone regulator Bag101 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein ptf2 Neighboring gene 40S ribosomal protein uS3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Topoisomerase III is required for accurate DNA replication and chromosome segregation in Schizosaccharomyces pombe. Oh M, et al. Nucleic Acids Res, 2002 Sep 15. PMID 12235386, Free PMC Article
    2. The top3(+) gene is essential in Schizosaccharomyces pombe and the lethality associated with its loss is caused by Rad12 helicase activity. Maftahi M, et al. Nucleic Acids Res, 1999 Dec 15. PMID 10572171, Free PMC Article
    3. Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombe. Goodwin A, et al. Nucleic Acids Res, 1999 Oct 15. PMID 10497270, Free PMC Article
    4. The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function. Ahmad F, et al. Mol Genet Genomics, 2005 Mar. PMID 15702347
    5. Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity. Win TZ, et al. J Cell Sci, 2004 Sep 15. PMID 15340008

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA topological change IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homologous recombination EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitotic DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postreplication repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in recombination within rDNA repeats EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RecQ family helicase-topoisomerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RecQ family helicase-topoisomerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase III

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4233868..4236269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023781.3 → NP_596761.1  DNA topoisomerase III [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596761.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O60126
      Conserved Domains (3) summary
      cd03362
      Location:2 → 162
      TOPRIM_TopoIA_TopoIII; TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving ...
      COG0550
      Location:3 → 615
      TopA; DNA topoisomerase IA [Replication, recombination and repair]
      cd00186
      Location:168 → 596
      TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
    Nucleotide Protein
    Heading Accession and Version

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