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    OM45 Om45p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854670, updated on 9-Jun-2024

    Summary

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    Gene symbol
    OM45
    Gene description
    Om45p
    Primary source
    FungiDB:YIL136W
    Locus tag
    YIL136W
    See related
    SGD:S000001398; AllianceGenome:SGD:S000001398; VEuPathDB:YIL136W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in mitochondrial outer membrane. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See OM45 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (93619..94800)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene tropomyosin TPM2 Neighboring gene Tma108p Neighboring gene Vhs2p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The major 45-kDa protein of the yeast mitochondrial outer membrane is not essential for cell growth or mitochondrial function. Yaffe MP, et al. J Biol Chem, 1989 Dec 15. PMID 2687271
    2. Interaction network of the mitochondrial outer membrane protein Mcp3. Sinzel M, et al. FEBS Lett, 2018 Oct. PMID 30192984
    3. Two mutations in mitochondrial ATP6 gene of ATP synthase, related to human cancer, affect ROS, calcium homeostasis and mitochondrial permeability transition in yeast. Niedzwiecka K, et al. Biochim Biophys Acta Mol Cell Res, 2018 Jan. PMID 28986220
    4. The presequence pathway is involved in protein sorting to the mitochondrial outer membrane. Wenz LS, et al. EMBO Rep, 2014 Jun. PMID 24781695, Free PMC Article
    5. Signal-anchor domains of proteins of the outer membrane of mitochondria: structural and functional characteristics. Waizenegger T, et al. J Biol Chem, 2003 Oct 24. PMID 12917440

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The N-terminal 50 residues direct Om45 to the mitochondrial intermembrane space.
      Title: A novel import route for an N-anchor mitochondrial outer membrane protein aided by the TIM23 complex.
    2. Saccharomyces cerevisiae porin pore forms complexes with mitochondrial outer membrane proteins Om14p and Om45p.
      Title: Saccharomyces cerevisiae porin pore forms complexes with mitochondrial outer membrane proteins Om14p and Om45p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Om45p
    NP_012130.1
    • Mitochondrial outer membrane hypothetical protein; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      93619..94800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179484.1 → NP_012130.1  TPA: Om45p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012130.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVF0, P16547
      UniProtKB/TrEMBL
      A0A6L1AK43, A6ZVD9, B3LTY4, C7GUQ4, C8ZAX7, G2WG15
      Conserved Domains (1) summary
      PTZ00121
      Location:126 → 384
      PTZ00121; MAEBL; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16547.2

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