HXT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HXT1
Primary source: SGD:S000001136
Locus tag: YHR094C
See related: AllianceGenome:SGD:S000001136; FungiDB:YHR094C; VEuPathDB:YHR094C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HOR4
Summary: Enables fructose transmembrane transporter activity and pentose transmembrane transporter activity. Involved in glucose transmembrane transport and mannose transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (290913..292625, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Local anesthetics and antipsychotic phenothiazine inhibit uptake of glucose by interacting nonspecifically with hexose transporter HXT1
Title: Local Anesthetics and Antipsychotic Phenothiazines Interact Nonspecifically with Membranes and Inhibit Hexose Transporters in Yeast.
Results show that Hxt1 transports 2-NBDG in a mechanism similar to human glucose transporters and, that some of the putative glucose-binding residues of Hxt1 are involved in endocytosis with N370 residue as critical for its stability and function.
Title: Assessing glucose uptake through the yeast hexose transporter 1 (Hxt1).
Data show that Pph3-Psy2 targets the glucose signal transducer protein Mth1, which is required for the dephosphorylation of Rgt1 upon glucose withdrawal, a critical event in the repression of HXT genes, which encode glucose transporters.
Title: Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression.
Association of the HXT1 mRNA with polysomes is regulated by SIT4.
Title: Expression of the glucose transporter HXT1 involves the Ser-Thr protein phosphatase Sit4 in Saccharomyces cerevisiae.
Hxk2 is required for the high expression of HXT1.
Title: Different signalling pathways mediate glucose induction of SUC2, HXT1 and pyruvate decarboxylase in yeast.
TOR kinase pathway participates actively in the induction of HXT1 expression by glucose. Inhibition of the TOR kinase pathway by rapamycin treatment abolishes HXT1 glucose induction.
Title: TOR kinase pathway and 14-3-3 proteins regulate glucose-induced expression of HXT1, a yeast low-affinity glucose transporter.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables carbohydrate:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables galactose transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables glucose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glucose transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables mannose transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables pentose transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in galactose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glucose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mannose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pentose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hexose transporter HXT1

NP_011962.1

Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

290913..292625 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179224.1 → NP_011962.1 TPA: hexose transporter HXT1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011962.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DL45, P32465

UniProtKB/TrEMBL

A6ZT03, C8Z9N8

Conserved Domains (1) summary

pfam00083
Location:68 → 528

Sugar_tr; Sugar (and other) transporter