U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CDC12 septin CDC12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856507, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CDC12
    Official Full Name
    septin CDC12
    Primary source
    SGD:S000001149
    Locus tag
    YHR107C
    See related
    AllianceGenome:SGD:S000001149; FungiDB:YHR107C; VEuPathDB:YHR107C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CLA10; PSL7
    Summary
    Enables several functions, including GTP binding activity; GTPase activity; and phosphatidylinositol phosphate binding activity. A structural constituent of cytoskeleton. Involved in cytoskeleton organization; maintenance of cell polarity; and positive regulation of protein kinase activity. Located in cellular bud scar; mating projection; and septin cytoskeleton. Part of septin complex. Orthologous to several human genes including SEPTIN2 (septin 2). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CDC12 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (326813..328036, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ypt35p Neighboring gene thioredoxin-disulfide reductase TRR2 Neighboring gene phosphatidylinositol 4-phosphate-binding protein Neighboring gene cytochrome c lysine N-methyltransferase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. LIVE-PAINT allows super-resolution microscopy inside living cells using reversible peptide-protein interactions. Oi C, et al. Commun Biol, 2020 Aug 20. PMID 32820217, Free PMC Article
    2. A septin from the filamentous fungus A. nidulans induces atypical pseudohyphae in the budding yeast S. cerevisiae. Lindsey R, et al. PLoS One, 2010 Mar 25. PMID 20360845, Free PMC Article
    3. Targeting metastable coiled-coil domains by computational design. Barth P, et al. J Am Chem Soc, 2008 Sep 10. PMID 18698842
    4. Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling. Woods BL, et al. Mol Biol Cell, 2021 Oct 1. PMID 34319771, Free PMC Article
    5. Septin filaments exhibit a dynamic, paired organization that is conserved from yeast to mammals. DeMay BS, et al. J Cell Biol, 2011 Jun 13. PMID 21670216, Free PMC Article

    See all (184) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling.
      Title: Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling.
    2. We studied the interactions between actin and the FH2 domains of formins Cdc12, Bni1 and mDia1 to understand the factors underlying their different rates of polymerization. All-atom molecular dynamics simulations revealed two factors that influence actin filament elongation and correlate with the rates of elongation
      Title: Gating mechanisms during actin filament elongation by formins.
    3. during cytokinesis septin rings, located on both sides of the actomyosin ring, acted as barriers to compartmentalize the cortex around the cleavage site
      Title: Spatial coordination of cytokinetic events by compartmentalization of the cell cortex.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-5-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septin ring assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in septin ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck septin ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud scar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in mating projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in prospore membrane HDA PubMed 
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of septin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in septin filament array IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    septin CDC12
    NP_011975.1
    • Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      326813..328036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179237.1 → NP_011975.1  TPA: septin CDC12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011975.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL57, P32468
      UniProtKB/TrEMBL
      A6ZT15, B3LSM2, C7GLZ3, C8Z9Q0, G2WFI1, N1P284
      Conserved Domains (1) summary
      COG5019
      Location:16 → 404
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32468.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous