TIS11 Tis11p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TIS11
Official Full Name: Tis11p
Primary source: SGD:S000004126
Locus tag: YLR136C
See related: AllianceGenome:SGD:S000004126; FungiDB:YLR136C; VEuPathDB:YLR136C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CTH2
Summary: Enables mRNA binding activity and translation repressor activity. Involved in several processes, including electron transport coupled proton transport; negative regulation of gene expression; and response to iron ion starvation. Located in nucleus. Is active in mitochondrion. Orthologous to several human genes including ZFP36 (ZFP36 ring finger protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TIS11 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (415801..416658, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The yeast mRNA-binding protein Cth2 post-transcriptionally modulates ergosterol biosynthesis in response to iron deficiency.
Title: The yeast mRNA-binding protein Cth2 post-transcriptionally modulates ergosterol biosynthesis in response to iron deficiency.
Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function.
Title: Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function.
Results demonstrate that the Cth2 CTD is physiologically relevant for adaptation to iron deficiency.
Title: Yeast Cth2 protein represses the translation of ARE-containing mRNAs in response to iron deficiency.
Cth2 protein mediates early adaptation of yeast cells to oxidative stress conditions.
Title: Cth2 Protein Mediates Early Adaptation of Yeast Cells to Oxidative Stress Conditions.
Negative feedback regulation of the CTH1 and CTH2 mRNA binding proteins is required for adaptation to iron deficiency and iron supplementation.
Title: Negative feedback regulation of the yeast CTH1 and CTH2 mRNA binding proteins is required for adaptation to iron deficiency and iron supplementation.
Cth2 protein recruits the Dhh1 helicase to ARE-containing mRNAs to promote SDH4 mRNA decay
Title: The Cth2 ARE-binding protein recruits the Dhh1 helicase to promote the decay of succinate dehydrogenase SDH4 mRNA in response to iron deficiency.
metabolic reprogramming as a consequence of Fe starvation that is dependent on the coordinated activities of CTH1 and CTH2
Title: Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables translation repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in electron transport coupled proton transport	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytoplasmic translation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to iron ion starvation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tis11p

NP_013237.1

mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; represses mitochondrial function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

415801..416658 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182023.1 → NP_013237.1 TPA: Tis11p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013237.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYD1, P47977

UniProtKB/TrEMBL

A7A135, B3LT97, B5VN65, C7GMI8, C8ZDA5, G2WIX5, N1NZQ0

Conserved Domains (1) summary

COG5063
Location:2 → 283

CTH1; CCCH-type Zn-finger protein [General function prediction only]