U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    xlf1 XRCC4-like factor xlf1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539197, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    xlf1
    Official Full Name
    XRCC4-like factor xlf1
    Primary source
    PomBase:SPCC24B10.14c
    Locus tag
    SPOM_SPCC24B10.14C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mug104; nej1
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See xlf1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (924212..925091, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Shk1 kinase-binding protein 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene 5S ribosomal RNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Xlf1 is required for DNA repair by nonhomologous end joining in Schizosaccharomyces pombe. Cavero S, et al. Genetics, 2007 Feb. PMID 17151234, Free PMC Article
    2. Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos. Hentges P, et al. J Biol Chem, 2006 Dec 8. PMID 17038309
    3. Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1. Hentges P, et al. Cell Rep, 2014 Dec 24. PMID 25533340, Free PMC Article
    4. The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components. Salas-Pino S, et al. J Cell Biol, 2017 Nov 6. PMID 28974540, Free PMC Article
    5. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Xlf1 is a key regulator of NHEJ activity in the cell cycle.
      Title: Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1.
    2. xlf1+, a gene in the fission yeast Schizosaccharomyces pombe that is required for repair of double-strand breaks by nonhomologous end joining during G1 phase of the cell cycle.
      Title: Xlf1 is required for DNA repair by nonhomologous end joining in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via classical nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA ligase IV complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    XRCC4-like factor xlf1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      924212..925091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355897.2 → NP_001342946.1  XRCC4-like factor xlf1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P7J2
      Conserved Domains (1) summary
      pfam09302
      Location:2 → 160
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials