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    PPH21 phosphoprotein phosphatase 2A catalytic subunit PPH21 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851421, updated on 7-Jul-2024

    Summary

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    Gene symbol
    PPH21
    Gene description
    phosphoprotein phosphatase 2A catalytic subunit PPH21
    Primary source
    FungiDB:YDL134C
    Locus tag
    YDL134C
    See related
    SGD:S000002292; AllianceGenome:SGD:S000002292; VEuPathDB:YDL134C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; peptidyl-serine dephosphorylation; and positive regulation of autophagosome assembly. Acts upstream of or within regulation of TORC1 signaling. Located in cytoplasmic stress granule and nucleus. Part of protein phosphatase type 2A complex. Orthologous to several human genes including PPP2CA (protein phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PPH21 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (219662..220771, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L35B Neighboring gene Rdi1p Neighboring gene ribosomal 60S subunit protein L41B Neighboring gene Srf1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers. Gentry MS, et al. Eukaryot Cell, 2005 Jun. PMID 15947195, Free PMC Article
    2. Role of protein phosphatase 2A in the control of glycogen metabolism in yeast. Clotet J, et al. Eur J Biochem, 1995 Apr 1. PMID 7744031
    3. Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes. Sneddon AA, et al. EMBO J, 1990 Dec. PMID 2176150, Free PMC Article
    4. Molecular genetic analysis of Rts1p, a B' regulatory subunit of Saccharomyces cerevisiae protein phosphatase 2A. Shu Y, et al. Mol Cell Biol, 1997 Jun. PMID 9154823, Free PMC Article
    5. Analysis of a 26,756 bp segment from the left arm of yeast chromosome IV. Wölfl S, et al. Yeast, 1996 Dec. PMID 8972577

    See all (132) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we conclude that Siw14 functions upstream of Pph21 and Pph22 as an inhibitor of the phosphorylation and localization of Gln3, and that Sit4 acts independently of Siw14
      Title: The protein phosphatase Siw14 controls caffeine-induced nuclear localization and phosphorylation of Gln3 via the type 2A protein phosphatases Pph21 and Pph22 in Saccharomyces cerevisiae.
    2. regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast
      Title: Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast.
    3. Pph21-Myc(13) (Ppp21 tagged at the C terminus with 13 copies of the Myc epitope) weakly associates with the DAL5 promoter in a Gat1-dependent manner, whereas a similar Pph22-Myc(13) association requires both Gln3 and Gat1.
      Title: Intranuclear function for protein phosphatase 2A: Pph21 and Pph22 are required for rapamycin-induced GATA factor binding to the DAL5 promoter in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of translation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoprotein phosphatase 2A catalytic subunit PPH21
    NP_010147.1
    • Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph22p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      219662..220771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180193.1 → NP_010147.1  TPA: phosphoprotein phosphatase 2A catalytic subunit PPH21 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010147.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRL4, P23594
      UniProtKB/TrEMBL
      A0A6A5PX39, A6ZXJ3, B3LH26, C7GSS9, C8Z6G8, G2WC27, N1P5T1
      Conserved Domains (1) summary
      cd07415
      Location:70 → 352
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23594.1

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