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    cdc42 Rho family GTPase Cdc42 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543027, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cdc42
    Official Full Name
    Rho family GTPase Cdc42
    Primary source
    PomBase:SPAC110.03
    Locus tag
    SPOM_SPAC110.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cdc42 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (1916009..1917656)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene mitotic and meiotic cohesin loader subunit Pds5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene heat shock protein Pss1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stress-dependent inhibition of polarized cell growth through unbalancing the GEF/GAP regulation of Cdc42. Salat-Canela C, et al. Cell Rep, 2021 Nov 2. PMID 34731607
    2. Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GTPase-activating protein Rga4 in fission yeast. Rich-Robinson J, et al. J Cell Sci, 2021 Oct 1. PMID 34523683, Free PMC Article
    3. Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast. Lamas I, et al. Cells, 2020 Sep 12. PMID 32932721, Free PMC Article
    4. Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking. Bendezú FO, et al. PLoS Biol, 2015 Apr. PMID 25837586, Free PMC Article
    5. Cdc42 regulates polarized growth and cell integrity in fission yeast. Rincón SA, et al. Biochem Soc Trans, 2014 Feb. PMID 24450652

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast.
      Title: Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast.
    2. Stress-dependent inhibition of polarized cell growth through unbalancing the GEF/GAP regulation of Cdc42.
      Title: Stress-dependent inhibition of polarized cell growth through unbalancing the GEF/GAP regulation of Cdc42.
    3. Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GTPase-activating protein Rga4 in fission yeast.
      Title: Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GTPase-activating protein Rga4 in fission yeast.
    4. Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast.
      Title: Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast.
    5. Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction.
      Title: Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction.
    6. Cdc42 activation pattern by GEF1 and Scd1 promotes different events during cytokinesis.
      Title: Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis.
    7. cells evolved highly robust symmetry-breaking mechanisms that rely on feedback amplification of local Cdc42 activity. In turn, local Cdc42 activity favors Cdc42 accumulation because active Cdc42 is poorly mobile relative to the inactive form.
      Title: Spontaneous cell polarization: Feedback control of Cdc42 GTPase breaks cellular symmetry.
    8. Tea4-PP1 landmark promotes local Cdc42 activation and growth both through Cdc42 GEF recruitment and by creating a local trough in a Cdc42 GAP.
      Title: The Tea4-PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion.
    9. Regulation of Cdc42 activity and localization and polarized cell growth in Schizosaccharomyces pombe. [Review]
      Title: Cdc42 regulates polarized growth and cell integrity in fission yeast.
    10. REVIEW: Cdc42 dynamics in the control of fission yeast cell polarization
      Title: Role of Cdc42 dynamics in the control of fission yeast cell polarization.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bipolar cell growth EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic nuclear membrane biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mating projection assembly EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in positive regulation of mating projection assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of beta-glucan biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of division septum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of cell polarity regulating cell shape EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of exocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signaling NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    part_of Cdc42 GTPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex of growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cortical dynamic polarity patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in exocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lateral cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane of cell tip EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rho family GTPase Cdc42

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1916009..1917656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018970.3 → NP_593536.1  Rho family GTPase Cdc42 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593536.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q01112
      Conserved Domains (2) summary
      smart00174
      Location:6 → 179
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01874
      Location:3 → 177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    Nucleotide Protein
    Heading Accession and Version

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