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    Brd8 bromodomain containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291691, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Brd8provided by RGD
    Official Full Name
    bromodomain containing 8provided by RGD
    Primary source
    RGD:1307003
    See related
    EnsemblRapid:ENSRNOG00000020340 AllianceGenome:RGD:1307003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p120
    Summary
    Predicted to enable nuclear receptor coactivator activity and thyroid hormone receptor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of NuA4 histone acetyltransferase complex and Swr1 complex. Biomarker of colorectal adenocarcinoma. Orthologous to human BRD8 (bromodomain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 114.2), Testes (RPKM 94.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    18p12
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26455824..26504106, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26204892..26229999, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27375645..27423989, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene Wnt family member 8A Neighboring gene uncharacterized LOC134482927 Neighboring gene NME/NM23 family member 5 Neighboring gene kinesin family member 20A Neighboring gene cell division cycle 23 Neighboring gene GDNF family receptor alpha 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effects of nicorandil on p120 expression in the spinal cord and dorsal root ganglion of rats with chronic postsurgical pain. Huang SS, et al. Mol Med Rep, 2020 Dec. PMID 33173987, Free PMC Article
    2. Co-activator p120 is increased by gonadotropins in the rat ovary and enhances progesterone receptor activity. Yoshino M, et al. Reprod Biol Endocrinol, 2006 Oct 3. PMID 17014737, Free PMC Article
    3. BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy. Yamada HY, et al. Int J Oncol, 2009 Nov. PMID 19787264
    4. ANP32E is a histone chaperone that removes H2A.Z from chromatin. Obri A, et al. Nature, 2014 Jan 30. PMID 24463511
    5. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of nicorandil on p120 expression in the spinal cord and dorsal root ganglion of rats with chronic postsurgical pain.
      Title: Effects of nicorandil on p120 expression in the spinal cord and dorsal root ganglion of rats with chronic postsurgical pain.
    2. BRD8 expression is associated with tumor progression toward advanced stages
      Title: BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to thyroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Swr1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008509.1 → NP_001008509.1  bromodomain-containing protein 8 isoform 2

      See identical proteins and their annotated locations for NP_001008509.1

      Status: VALIDATED

      Source sequence(s)
      AB180485
      UniProtKB/TrEMBL
      A0A8I6ATL0, Q5TLG7
      Related
      ENSRNOP00000076647.2, ENSRNOT00000118939.2
      Conserved Domains (1) summary
      cd05507
      Location:788 → 891
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...

    2. NM_001414410.1 → NP_001401339.1  bromodomain-containing protein 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2JWN9
      Related
      ENSRNOP00000069953.2, ENSRNOT00000087968.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      26455824..26504106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277225.1 → XP_063133295.1  bromodomain-containing protein 8 isoform X3

    2. XM_063277224.1 → XP_063133294.1  bromodomain-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      F1M858
      Related
      ENSRNOP00000033259.6, ENSRNOT00000034385.7

    3. XM_063277223.1 → XP_063133293.1  bromodomain-containing protein 8 isoform X1

      Related
      ENSRNOP00000095490.2, ENSRNOT00000101754.2

    4. XM_063277234.1 → XP_063133304.1  bromodomain-containing protein 8 isoform X14

    5. XM_063277233.1 → XP_063133303.1  bromodomain-containing protein 8 isoform X14

    6. XM_063277229.1 → XP_063133299.1  bromodomain-containing protein 8 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JWN9

    7. XM_006254564.5 → XP_006254626.1  bromodomain-containing protein 8 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JWN9
      Conserved Domains (1) summary
      cd05507
      Location:709 → 812
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...

    8. XM_017600912.3 → XP_017456401.1  bromodomain-containing protein 8 isoform X9

      UniProtKB/TrEMBL
      A0A0G2JWN9

    9. XM_063277228.1 → XP_063133298.1  bromodomain-containing protein 8 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JWN9, A0A8I6AR97
      Related
      ENSRNOP00000095492.1, ENSRNOT00000106891.2

    10. XM_039096725.2 → XP_038952653.1  bromodomain-containing protein 8 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JWN9, E9PTN1
      Related
      ENSRNOP00000050917.3, ENSRNOT00000048752.5
      Conserved Domains (3) summary
      cd05507
      Location:782 → 885
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
      PHA03247
      Location:176 → 419
      PHA03247; large tegument protein UL36; Provisional
      PRK14971
      Location:356 → 484
      PRK14971; DNA polymerase III subunit gamma/tau

    11. XM_063277227.1 → XP_063133297.1  bromodomain-containing protein 8 isoform X6

      UniProtKB/TrEMBL
      A0A8I5XUT9, A0A8I6ATL0

    12. XM_063277226.1 → XP_063133296.1  bromodomain-containing protein 8 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ATL0

    13. XM_063277231.1 → XP_063133301.1  bromodomain-containing protein 8 isoform X12

    14. XM_063277232.1 → XP_063133302.1  bromodomain-containing protein 8 isoform X13

    15. XM_063277230.1 → XP_063133300.1  bromodomain-containing protein 8 isoform X11

    Nucleotide Protein Strain
    Heading Accession and Version

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