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    SLCO4A1 solute carrier organic anion transporter family member 4A1 [ Homo sapiens (human) ]

    Gene ID: 28231, updated on 3-Dec-2024

    Summary

    Official Symbol
    SLCO4A1provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 4A1provided by HGNC
    Primary source
    HGNC:HGNC:10953
    See related
    Ensembl:ENSG00000101187 MIM:612436; AllianceGenome:HGNC:10953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POAT; OATP1; OATPE; OATP-E; OATP4A1; OATPRP1; SLC21A12
    Summary
    Enables organic anion transmembrane transporter activity and prostaglandin transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 2.4), endometrium (RPKM 1.6) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLCO4A1 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62642503..62690740)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64441223..64489475)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61273855..61303645)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61266847-61267348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61267349-61267848 Neighboring gene uncharacterized LOC124904949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61279493-61280066 Neighboring gene SLCO4A1 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18213 Neighboring gene SLCO4A1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61302735-61303693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61314847-61315390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61315391-61315933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61339152-61339665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61339666-61340178 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61340388-61340934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61340935-61341479 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61352726-61352918 Neighboring gene neurotensin receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61354746-61355285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61366135-61366980 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:61371112-61372311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61392433-61393212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61400285-61401016 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61407515-61407676 Neighboring gene long intergenic non-protein coding RNA 659

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLCO4A1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostaglandin transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in thyroid hormone transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier organic anion transporter family member 4A1
    Names
    OATP-RP1
    colon organic anion transporter
    organic anion transporter polypeptide-related protein 1
    organic anion transporting polypeptide E
    sodium-independent organic anion transporter E
    solute carrier family 21 (organic anion transporter), member 12
    solute carrier family 21 member 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016354.4NP_057438.3  solute carrier organic anion transporter family member 4A1

      See identical proteins and their annotated locations for NP_057438.3

      Status: VALIDATED

      Source sequence(s)
      AB031051, AF205072, AI660559, BC015727, BM846201
      Consensus CDS
      CCDS13501.1
      UniProtKB/Swiss-Prot
      Q96BD0, Q9H4T7, Q9H4T8, Q9H8P2, Q9NWX8, Q9UI35, Q9UIG7
      Related
      ENSP00000217159.1, ENST00000217159.6
      Conserved Domains (3) summary
      cd06174
      Location:106489
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:500555
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:106663
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      62642503..62690740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260203.4XP_005260260.1  solute carrier organic anion transporter family member 4A1 isoform X3

      UniProtKB/TrEMBL
      E1P5H9, H0UI88
      Related
      ENSP00000434245.1, ENST00000497209.5
      Conserved Domains (3) summary
      cd06174
      Location:106489
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:500555
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:106663
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    2. XM_011528792.4XP_011527094.1  solute carrier organic anion transporter family member 4A1 isoform X1

      Conserved Domains (3) summary
      cd06174
      Location:106489
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:500555
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:106663
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    3. XM_017027827.3XP_016883316.1  solute carrier organic anion transporter family member 4A1 isoform X2

    4. XM_047440126.1XP_047296082.1  solute carrier organic anion transporter family member 4A1 isoform X4

    RNA

    1. XR_001754251.3 RNA Sequence

    2. XR_007067450.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      64441223..64489475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323385.1XP_054179360.1  solute carrier organic anion transporter family member 4A1 isoform X3

      UniProtKB/TrEMBL
      E1P5H9, H0UI88
    2. XM_054323380.1XP_054179355.1  solute carrier organic anion transporter family member 4A1 isoform X1

    3. XM_054323383.1XP_054179358.1  solute carrier organic anion transporter family member 4A1 isoform X2

    4. XM_054323387.1XP_054179362.1  solute carrier organic anion transporter family member 4A1 isoform X4

    5. XM_054323382.1XP_054179357.1  solute carrier organic anion transporter family member 4A1 isoform X5

      UniProtKB/Swiss-Prot
      Q96BD0, Q9H4T7, Q9H4T8, Q9H8P2, Q9NWX8, Q9UI35, Q9UIG7
    6. XM_054323384.1XP_054179359.1  solute carrier organic anion transporter family member 4A1 isoform X2

    7. XM_054323386.1XP_054179361.1  solute carrier organic anion transporter family member 4A1 isoform X3

      UniProtKB/TrEMBL
      E1P5H9, H0UI88
    8. XM_054323381.1XP_054179356.1  solute carrier organic anion transporter family member 4A1 isoform X1

    RNA

    1. XR_008485252.1 RNA Sequence

    2. XR_008485253.1 RNA Sequence