MST1R macrophage stimulating 1 receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: MST1Rprovided by HGNC
Official Full Name: macrophage stimulating 1 receptorprovided by HGNC
Primary source: HGNC:HGNC:7381
See related: Ensembl:ENSG00000164078 MIM:600168; AllianceGenome:HGNC:7381
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RON; SEA; PTK8; CD136; NPCA3; CDw136; p185-Ron
Summary: This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]
Expression: Biased expression in skin (RPKM 17.5), stomach (RPKM 16.3) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p21.31

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (49887002..49903873, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (49916899..49933769, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (49924435..49941306, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An Introduction and Overview of RON Receptor Tyrosine Kinase Signaling.
Title: An Introduction and Overview of RON Receptor Tyrosine Kinase Signaling.
EGFR transactivates RON to drive oncogenic crosstalk.
Title: EGFR transactivates RON to drive oncogenic crosstalk.
Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating beta-catenin/SIX1 signaling pathway in gastric cancer.
Title: Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer.
A potential signaling axis between RON kinase receptor and hypoxia-inducible factor-1 alpha in pancreatic cancer.
Title: A potential signaling axis between RON kinase receptor and hypoxia-inducible factor-1 alpha in pancreatic cancer.
Recepteur d'origine nantais contributes to the development of endometriosis via promoting epithelial-mesenchymal transition of a endometrial epithelial cells.
Title: Recepteur d'origine nantais contributes to the development of endometriosis via promoting epithelial-mesenchymal transition of a endometrial epithelial cells.
Tumor cell intrinsic RON signaling suppresses innate immune responses in breast cancer through inhibition of IRAK4 signaling.
Title: Tumor cell intrinsic RON signaling suppresses innate immune responses in breast cancer through inhibition of IRAK4 signaling.
MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy.
Title: MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy.
RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer.
Title: RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer.
Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer.
Title: Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer.
RON and MET Co-overexpression Are Significant Pathological Characteristics of Poor Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Triple-Negative Breast Cancer.
Title: RON and MET Co-overexpression Are Significant Pathological Characteristics of Poor Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Triple-Negative Breast Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (137)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Nasopharyngeal carcinoma, susceptibility to, 3 MedGen: C4310729 OMIM: 617075 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Tat trans activation domain and the integrity of the kinase domain of RON receptor are required for Tat-mediated degradation of RON	PubMed
	tat	Tat decreases cell surface RON expression in HIV-infected monocytic cells, and this Tat-mediated degradation of RON protein is blocked by inhibitors of proteasome activity	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH18128 (e-PCR)
- UniSTS:73827

SHGC-11997 (e-PCR)
- UniSTS:38615

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in defense response	TAS Traceable Author Statement more info	PubMed
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in single fertilization	TAS Traceable Author Statement more info	PubMed
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: macrophage-stimulating protein receptor

Names: MSP receptor; PTK8 protein tyrosine kinase 8; S13 avian erythroblastosis oncogene homolog; S13 erythroblastosis oncogene homolog; c-met-related tyrosine kinase

NP_001231866.1

EC 2.7.10.1

NP_001305842.1

EC 2.7.10.1

NP_002438.2

EC 2.7.10.1

XP_005265227.2

EC 2.7.10.1

XP_011532041.1

EC 2.7.10.1

XP_011532042.1

EC 2.7.10.1

XP_011532043.1

EC 2.7.10.1

XP_011532044.1

EC 2.7.10.1

XP_011532045.1

EC 2.7.10.1

XP_011532046.1

EC 2.7.10.1

XP_047304118.1

EC 2.7.10.1

XP_047304119.1

EC 2.7.10.1

XP_047304120.1

EC 2.7.10.1

XP_047304121.1

EC 2.7.10.1

XP_047304122.1

EC 2.7.10.1

XP_047304123.1

EC 2.7.10.1

XP_047304124.1

EC 2.7.10.1

XP_047304125.1

EC 2.7.10.1

XP_047304126.1

EC 2.7.10.1

XP_047304127.1

EC 2.7.10.1

XP_047304128.1

EC 2.7.10.1

XP_047304129.1

EC 2.7.10.1

XP_047304130.1

EC 2.7.10.1

XP_047304131.1

EC 2.7.10.1

XP_047304132.1

EC 2.7.10.1

XP_047304133.1

EC 2.7.10.1

XP_047304134.1

EC 2.7.10.1

XP_047304135.1

EC 2.7.10.1

XP_047304136.1

EC 2.7.10.1

XP_054202561.1

EC 2.7.10.1

XP_054202562.1

EC 2.7.10.1

XP_054202563.1

EC 2.7.10.1

XP_054202564.1

EC 2.7.10.1

XP_054202565.1

EC 2.7.10.1

XP_054202566.1

EC 2.7.10.1

XP_054202567.1

EC 2.7.10.1

XP_054202568.1

EC 2.7.10.1

XP_054202569.1

EC 2.7.10.1

XP_054202570.1

EC 2.7.10.1

XP_054202571.1

EC 2.7.10.1

XP_054202572.1

EC 2.7.10.1

XP_054202573.1

EC 2.7.10.1

XP_054202574.1

EC 2.7.10.1

XP_054202575.1

EC 2.7.10.1

XP_054202576.1

EC 2.7.10.1

XP_054202577.1

EC 2.7.10.1

XP_054202578.1

EC 2.7.10.1

XP_054202579.1

EC 2.7.10.1

XP_054202580.1

EC 2.7.10.1

XP_054202581.1

EC 2.7.10.1

XP_054202582.1

EC 2.7.10.1

XP_054202583.1

EC 2.7.10.1

XP_054202584.1

EC 2.7.10.1

XP_054202585.1

EC 2.7.10.1

XP_054202586.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030322.1 RefSeqGene

Range

5001..21872

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001244937.3 → NP_001231866.1 macrophage-stimulating protein receptor isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as isoform delta-Ron) missing an internal segment compared to isoform 1.

Source sequence(s)

AC105935, AK303234, BU542597, CA503122, EU826584, X70040

Consensus CDS

CCDS58833.1

UniProtKB/TrEMBL

H7C3Z8

Related

ENSP00000341325.4, ENST00000344206.8

Conserved Domains (7) summary

smart00219
Location:1036 → 1289

TyrKc; Tyrosine kinase, catalytic domain

cd11279
Location:27 → 523

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00429
Location:769 → 859

IPT; ig-like, plexins, transcription factors

cd01179
Location:684 → 768

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:569 → 683

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:1037 → 1298

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam01437
Location:526 → 565

PSI; Plexin repeat
NM_001318913.2 → NP_001305842.1 macrophage-stimulating protein receptor isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform 3 which is shorter than isoform 1. This isoform (3) may undergo proteolytic processing similar to isoform 1.

Source sequence(s)

AC105935, CA503122, JN983806

Consensus CDS

CCDS82777.1

UniProtKB/TrEMBL

G9JXB8

Related

ENSP00000482642.1, ENST00000621387.4

Conserved Domains (7) summary

smart00219
Location:979 → 1232

TyrKc; Tyrosine kinase, catalytic domain

smart00429
Location:663 → 753

IPT; ig-like, plexins, transcription factors

cd01179
Location:578 → 662

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:463 → 577

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:980 → 1241

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam01437
Location:420 → 459

PSI; Plexin repeat

cl15693
Location:27 → 426

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
NM_002447.4 → NP_002438.2 macrophage-stimulating protein receptor isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as isoform Ron).

Source sequence(s)

AC105935, CA503122, X70040

Consensus CDS

CCDS2807.1

UniProtKB/Swiss-Prot

A0A087WZG2, B5A944, B5A945, B5A946, B5A947, Q04912

UniProtKB/TrEMBL

H7C3Z8

Related

ENSP00000296474.3, ENST00000296474.8

Conserved Domains (6) summary

cd11279
Location:27 → 523

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00429
Location:769 → 859

IPT; ig-like, plexins, transcription factors

cd01179
Location:684 → 768

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:569 → 683

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:1086 → 1347

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam01437
Location:526 → 565

PSI; Plexin repeat

RNA

NR_134919.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC105935, CA503122, HQ908652, JN983806

Related

ENST00000714252.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

49887002..49903873 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448174.1 → XP_047304130.1 macrophage-stimulating protein receptor isoform X20
XM_047448176.1 → XP_047304132.1 macrophage-stimulating protein receptor isoform X22
XM_047448177.1 → XP_047304133.1 macrophage-stimulating protein receptor isoform X23
XM_047448173.1 → XP_047304129.1 macrophage-stimulating protein receptor isoform X19
XM_047448175.1 → XP_047304131.1 macrophage-stimulating protein receptor isoform X21
XM_011533744.3 → XP_011532046.1 macrophage-stimulating protein receptor isoform X11

UniProtKB/TrEMBL

G9JXB8

Conserved Domains (7) summary

smart00219
Location:980 → 1233

TyrKc; Tyrosine kinase, catalytic domain

smart00429
Location:663 → 754

IPT; ig-like, plexins, transcription factors

cd01179
Location:578 → 662

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:463 → 577

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:981 → 1242

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam01437
Location:420 → 459

PSI; Plexin repeat

cl15693
Location:27 → 426

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_047448168.1 → XP_047304124.1 macrophage-stimulating protein receptor isoform X14
XM_047448170.1 → XP_047304126.1 macrophage-stimulating protein receptor isoform X16
XM_047448166.1 → XP_047304122.1 macrophage-stimulating protein receptor isoform X12
XM_047448162.1 → XP_047304118.1 macrophage-stimulating protein receptor isoform X3
XM_047448171.1 → XP_047304127.1 macrophage-stimulating protein receptor isoform X17
XM_047448163.1 → XP_047304119.1 macrophage-stimulating protein receptor isoform X6

UniProtKB/TrEMBL

H7C074

Related

ENSP00000393294.2, ENST00000434765.6
XM_047448165.1 → XP_047304121.1 macrophage-stimulating protein receptor isoform X10
XM_047448164.1 → XP_047304120.1 macrophage-stimulating protein receptor isoform X8
XM_047448167.1 → XP_047304123.1 macrophage-stimulating protein receptor isoform X13
XM_047448172.1 → XP_047304128.1 macrophage-stimulating protein receptor isoform X18
XM_047448169.1 → XP_047304125.1 macrophage-stimulating protein receptor isoform X15
XM_011533740.3 → XP_011532042.1 macrophage-stimulating protein receptor isoform X4

UniProtKB/TrEMBL

H7C3Z8

Conserved Domains (7) summary

smart00219
Location:1037 → 1290

TyrKc; Tyrosine kinase, catalytic domain

cd11279
Location:27 → 523

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00429
Location:769 → 860

IPT; ig-like, plexins, transcription factors

cd01179
Location:684 → 768

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:569 → 683

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:1038 → 1299

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam01437
Location:526 → 565

PSI; Plexin repeat
XM_011533739.3 → XP_011532041.1 macrophage-stimulating protein receptor isoform X2

UniProtKB/TrEMBL

H7C3Z8

Conserved Domains (7) summary

smart00219
Location:1046 → 1299

TyrKc; Tyrosine kinase, catalytic domain

cd11279
Location:27 → 523

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00429
Location:769 → 860

IPT; ig-like, plexins, transcription factors

cd01179
Location:684 → 768

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:569 → 683

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:1047 → 1308

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam01437
Location:526 → 565

PSI; Plexin repeat
XM_011533741.3 → XP_011532043.1 macrophage-stimulating protein receptor isoform X5

UniProtKB/TrEMBL

H7C3Z8

Conserved Domains (7) summary

smart00219
Location:1021 → 1270

TyrKc; Tyrosine kinase, catalytic domain

cd11279
Location:27 → 523

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00429
Location:769 → 860

IPT; ig-like, plexins, transcription factors

cd01179
Location:684 → 768

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:569 → 683

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:1021 → 1279

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam01437
Location:526 → 565

PSI; Plexin repeat
XM_011533743.3 → XP_011532045.1 macrophage-stimulating protein receptor isoform X9

UniProtKB/TrEMBL

H7C3Z8

Conserved Domains (6) summary

cd11279
Location:27 → 523

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00429
Location:769 → 860

IPT; ig-like, plexins, transcription factors

cd01179
Location:684 → 768

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:569 → 683

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:526 → 565

PSI; Plexin repeat

cl21453
Location:1087 → 1247

PKc_like; Protein Kinases, catalytic domain
XM_011533742.3 → XP_011532044.1 macrophage-stimulating protein receptor isoform X7

UniProtKB/TrEMBL

H7C3Z8

Conserved Domains (6) summary

cd11279
Location:27 → 523

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00429
Location:769 → 860

IPT; ig-like, plexins, transcription factors

cd01179
Location:684 → 768

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:569 → 683

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:526 → 565

PSI; Plexin repeat

cl21453
Location:1087 → 1271

PKc_like; Protein Kinases, catalytic domain
XM_005265170.5 → XP_005265227.2 macrophage-stimulating protein receptor isoform X1

UniProtKB/TrEMBL

H7C3Z8

Conserved Domains (7) summary

smart00219
Location:1086 → 1339

TyrKc; Tyrosine kinase, catalytic domain

cd11279
Location:27 → 523

Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase

smart00429
Location:769 → 860

IPT; ig-like, plexins, transcription factors

cd01179
Location:684 → 768

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:569 → 683

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:1087 → 1348

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam01437
Location:526 → 565

PSI; Plexin repeat
XM_047448178.1 → XP_047304134.1 macrophage-stimulating protein receptor isoform X24

Related

ENSP00000407926.2, ENST00000411578.6
XM_047448179.1 → XP_047304135.1 macrophage-stimulating protein receptor isoform X25
XM_047448180.1 → XP_047304136.1 macrophage-stimulating protein receptor isoform X26

Related

ENST00000468525.5

RNA

XR_001740155.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

49916899..49933769 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054346605.1 → XP_054202580.1 macrophage-stimulating protein receptor isoform X20
XM_054346607.1 → XP_054202582.1 macrophage-stimulating protein receptor isoform X22
XM_054346608.1 → XP_054202583.1 macrophage-stimulating protein receptor isoform X23
XM_054346604.1 → XP_054202579.1 macrophage-stimulating protein receptor isoform X19
XM_054346606.1 → XP_054202581.1 macrophage-stimulating protein receptor isoform X21
XM_054346596.1 → XP_054202571.1 macrophage-stimulating protein receptor isoform X11
XM_054346599.1 → XP_054202574.1 macrophage-stimulating protein receptor isoform X14
XM_054346601.1 → XP_054202576.1 macrophage-stimulating protein receptor isoform X16
XM_054346597.1 → XP_054202572.1 macrophage-stimulating protein receptor isoform X12
XM_054346588.1 → XP_054202563.1 macrophage-stimulating protein receptor isoform X3
XM_054346602.1 → XP_054202577.1 macrophage-stimulating protein receptor isoform X17
XM_054346591.1 → XP_054202566.1 macrophage-stimulating protein receptor isoform X6
XM_054346595.1 → XP_054202570.1 macrophage-stimulating protein receptor isoform X10
XM_054346593.1 → XP_054202568.1 macrophage-stimulating protein receptor isoform X8
XM_054346598.1 → XP_054202573.1 macrophage-stimulating protein receptor isoform X13
XM_054346603.1 → XP_054202578.1 macrophage-stimulating protein receptor isoform X18
XM_054346600.1 → XP_054202575.1 macrophage-stimulating protein receptor isoform X15
XM_054346587.1 → XP_054202562.1 macrophage-stimulating protein receptor isoform X2
XM_054346594.1 → XP_054202569.1 macrophage-stimulating protein receptor isoform X9
XM_054346592.1 → XP_054202567.1 macrophage-stimulating protein receptor isoform X7
XM_054346589.1 → XP_054202564.1 macrophage-stimulating protein receptor isoform X4
XM_054346590.1 → XP_054202565.1 macrophage-stimulating protein receptor isoform X5
XM_054346586.1 → XP_054202561.1 macrophage-stimulating protein receptor isoform X1
XM_054346609.1 → XP_054202584.1 macrophage-stimulating protein receptor isoform X24
XM_054346610.1 → XP_054202585.1 macrophage-stimulating protein receptor isoform X25
XM_054346611.1 → XP_054202586.1 macrophage-stimulating protein receptor isoform X26