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    ADD3 adducin 3 [ Homo sapiens (human) ]

    Gene ID: 120, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ADD3provided by HGNC
    Official Full Name
    adducin 3provided by HGNC
    Primary source
    HGNC:HGNC:245
    See related
    Ensembl:ENSG00000148700 MIM:601568; AllianceGenome:HGNC:245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADDL; CPSQ3
    Summary
    Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 57.5), thyroid (RPKM 50.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADD3 in Genome Data Viewer
    Location:
    10q25.1-q25.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (109996373..110135565)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (110880187..111019428)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (111756131..111895323)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:111585419-111585920 Neighboring gene ribosomal protein L21 pseudogene 91 Neighboring gene X-prolyl aminopeptidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3996 Neighboring gene RNA, U4 small nuclear 5, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3997 Neighboring gene NANOG hESC enhancer GRCh37_chr10:111672994-111673649 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3999 Neighboring gene ADD3 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr10:111747103-111747604 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:111766387-111766942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:111766943-111767496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:111774137-111774942 Neighboring gene Sharpr-MPRA regulatory region 15659 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4004 Neighboring gene Sharpr-MPRA regulatory region 905 Neighboring gene uncharacterized LOC105378479 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:111910896-111911890 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Adducin: Ca++-dependent association with sites of cell-cell contact. Kaiser HW, et al. J Cell Biol, 1989 Aug. PMID 2503523, Free PMC Article
    2. Posttranscriptional inhibition of γ-adducin promotes the proliferation and migration of osteosarcoma cells. Suo Z, et al. Tumori, 2022 Dec. PMID 34632867
    3. Loss of cytoskeleton protein ADD3 promotes tumor growth and angiogenesis in glioblastoma multiforme. Kiang KM, et al. Cancer Lett, 2020 Apr 1. PMID 31958485
    4. The intragenic epistatic association of ADD3 with biliary atresia in Southern Han Chinese population. Wang Z, et al. Biosci Rep, 2018 Jun 29. PMID 29685956, Free PMC Article
    5. Single nucleotide polymorphisms within Adducin 3 and Adducin 3 antisense RNA1 genes are associated with biliary atresia in Thai infants. Laochareonsuk W, et al. Pediatr Surg Int, 2018 May. PMID 29508064

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Contribution of ADD3 and the HLA Genes to Biliary Atresia Risk in Chinese.
      Title: Contribution of ADD3 and the HLA Genes to Biliary Atresia Risk in Chinese.
    2. Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived stem cells via miR-143-3p/ADD3 axis.
      Title: Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived stem cells via miR-143-3p/ADD3 axis.
    3. The correlation between rs2501577 gene polymorphism and biliary atresia: a systematic review and meta-analysis.
      Title: The correlation between rs2501577 gene polymorphism and biliary atresia: a systematic review and meta-analysis.
    4. Posttranscriptional inhibition of gamma-adducin promotes the proliferation and migration of osteosarcoma cells.
      Title: Posttranscriptional inhibition of γ-adducin promotes the proliferation and migration of osteosarcoma cells.
    5. QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer.
      Title: QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer.
    6. Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis.
      Title: Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis.
    7. Association of common variation in ADD3 and GPC1 with biliary atresia susceptibility.
      Title: Association of common variation in ADD3 and GPC1 with biliary atresia susceptibility.
    8. Increased expression of phosphorylated adducin in tumor cells.
      Title: Increased expression of phosphorylated adducin in tumor cells.
    9. Loss of cytoskeleton protein ADD3 promotes tumor growth and angiogenesis in glioblastoma multiforme.
      Title: Loss of cytoskeleton protein ADD3 promotes tumor growth and angiogenesis in glioblastoma multiforme.
    10. The intragenic epistatic association of ADD3 with biliary atresia in Southern Han Chinese population has been reported.
      Title: The intragenic epistatic association of ADD3 with biliary atresia in Southern Han Chinese population.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Cerebral palsy, spastic quadriplegic, 3
    MedGen: C4310767 OMIM: 617008 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of adducin 3 protein gamma (ADD3) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase C binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gamma-adducin
    Names
    adducin 3 (gamma)
    adducin-like protein 70

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051033.1 RefSeqGene

      Range
      16635..144216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001121.4 → NP_001112.2  gamma-adducin isoform b

      See identical proteins and their annotated locations for NP_001112.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1.The encoded isoform (b) is shorter than isoform a. Both variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      BC021694, BC057285, BX647403, CF457028
      Consensus CDS
      CCDS7562.1
      UniProtKB/TrEMBL
      Q59EK1
      Related
      ENSP00000277900.8, ENST00000277900.12
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    2. NM_001320591.2 → NP_001307520.1  gamma-adducin isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4-6 encode the same isoform (a).
      Source sequence(s)
      AK223270, BC043143, BC057285, EF553523
      Consensus CDS
      CCDS7561.1
      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    3. NM_001320592.2 → NP_001307521.1  gamma-adducin isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 and 4-6 encode the same isoform (a).
      Source sequence(s)
      AK223270, BC043143, BC057285, DA477660, EF553523
      Consensus CDS
      CCDS7561.1
      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    4. NM_001320593.2 → NP_001307522.1  gamma-adducin isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 4-6 encode the same isoform (a).
      Source sequence(s)
      AB209810, AK223270, BC043143, DA477660
      Consensus CDS
      CCDS7561.1
      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    5. NM_001320594.2 → NP_001307523.1  gamma-adducin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and initiates translation at a downstream start site compared to variant 1. The encoded isoform (c) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      BC021694, BC062559, CN428885, DA700119
      UniProtKB/TrEMBL
      Q53FL4
      Conserved Domains (1) summary
      cl00214
      Location:59 → 307
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    6. NM_016824.5 → NP_058432.1  gamma-adducin isoform a

      See identical proteins and their annotated locations for NP_058432.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 4-6 encode the same isoform (a).
      Source sequence(s)
      BC021694, BC057285, BC062559
      Consensus CDS
      CCDS7561.1
      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Related
      ENSP00000348381.4, ENST00000356080.9
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    7. NM_019903.5 → NP_063968.1  gamma-adducin isoform b

      See identical proteins and their annotated locations for NP_063968.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region compared to variant 1.The encoded isoform (b) is shorter than isoform a. Both variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      BC021694, BC057285, CF457028, D67031, DA477660
      Consensus CDS
      CCDS7562.1
      UniProtKB/TrEMBL
      Q59EK1
      Related
      ENSP00000353286.3, ENST00000360162.7
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      109996373..110135565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424588.1 → XP_047280544.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    2. XM_047424590.1 → XP_047280546.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    3. XM_047424587.1 → XP_047280543.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    4. XM_024447799.2 → XP_024303567.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    5. XM_047424595.1 → XP_047280551.1  gamma-adducin isoform X2

    6. XM_024447797.2 → XP_024303565.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    7. XM_024447806.2 → XP_024303574.1  gamma-adducin isoform X2

      UniProtKB/TrEMBL
      Q59EK1
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    8. XM_024447803.2 → XP_024303571.1  gamma-adducin isoform X2

      UniProtKB/TrEMBL
      Q59EK1
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    9. XM_024447796.2 → XP_024303564.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    10. XM_024447805.2 → XP_024303573.1  gamma-adducin isoform X2

      UniProtKB/TrEMBL
      Q59EK1
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    11. XM_024447801.1 → XP_024303569.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    12. XM_024447807.1 → XP_024303575.1  gamma-adducin isoform X2

      UniProtKB/TrEMBL
      Q59EK1
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    13. XM_024447795.1 → XP_024303563.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    14. XM_024447804.1 → XP_024303572.1  gamma-adducin isoform X2

      UniProtKB/TrEMBL
      Q59EK1
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    15. XM_047424589.1 → XP_047280545.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    16. XM_024447800.2 → XP_024303568.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    17. XM_047424593.1 → XP_047280549.1  gamma-adducin isoform X2

    18. XM_047424591.1 → XP_047280547.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    19. XM_047424594.1 → XP_047280550.1  gamma-adducin isoform X2

    20. XM_024447794.2 → XP_024303562.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    21. XM_024447798.1 → XP_024303566.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    22. XM_047424592.1 → XP_047280548.1  gamma-adducin isoform X2

    23. XM_024447802.2 → XP_024303570.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q59EK1, Q5VU08
      Conserved Domains (1) summary
      cl00214
      Location:137 → 385
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    24. XM_047424597.1 → XP_047280553.1  gamma-adducin isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      110880187..111019428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364768.1 → XP_054220743.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    2. XM_054364777.1 → XP_054220752.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    3. XM_054364774.1 → XP_054220749.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    4. XM_054364772.1 → XP_054220747.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    5. XM_054364787.1 → XP_054220762.1  gamma-adducin isoform X2

    6. XM_054364771.1 → XP_054220746.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    7. XM_054364785.1 → XP_054220760.1  gamma-adducin isoform X2

    8. XM_054364781.1 → XP_054220756.1  gamma-adducin isoform X2

    9. XM_054364778.1 → XP_054220753.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    10. XM_054364789.1 → XP_054220764.1  gamma-adducin isoform X2

    11. XM_054364776.1 → XP_054220751.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    12. XM_054364788.1 → XP_054220763.1  gamma-adducin isoform X2

    13. XM_054364767.1 → XP_054220742.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    14. XM_054364784.1 → XP_054220759.1  gamma-adducin isoform X2

    15. XM_054364770.1 → XP_054220745.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    16. XM_054364783.1 → XP_054220758.1  gamma-adducin isoform X2

    17. XM_054364775.1 → XP_054220750.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    18. XM_054364773.1 → XP_054220748.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    19. XM_054364769.1 → XP_054220744.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    20. XM_054364782.1 → XP_054220757.1  gamma-adducin isoform X2

    21. XM_054364786.1 → XP_054220761.1  gamma-adducin isoform X2

    22. XM_054364780.1 → XP_054220755.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    23. XM_054364779.1 → XP_054220754.1  gamma-adducin isoform X1

      UniProtKB/Swiss-Prot
      D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8
      UniProtKB/TrEMBL
      Q5VU08

    24. XM_054364790.1 → XP_054220765.1  gamma-adducin isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UEY8.1 GenPept UniProtKB/Swiss-Prot:Q9UEY8

    Gene LinkOut

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