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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_008916.1 RefSeqGene
- Range
-
4613..37971
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_288
mRNA and Protein(s)
-
NM_000238.4 → NP_000229.1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform a
See identical proteins and their annotated locations for NP_000229.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (a).
- Source sequence(s)
-
AC011234, AF363636, DQ525913, U04270
- Consensus CDS
-
CCDS5910.1
- UniProtKB/Swiss-Prot
- A5H1P7, C4PFH9, D3DX04, O75418, O75680, Q12809, Q708S9, Q9BT72, Q9BUT7, Q9H3P0
- UniProtKB/TrEMBL
- A0A090N8Q0, Q15BH2
- Related
- ENSP00000262186.5, ENST00000262186.10
- Conserved Domains (4) summary
-
- cd00038
Location:742 → 853
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- pfam00520
Location:409 → 668
- Ion_trans; Ion transport protein
- pfam13426
Location:29 → 130
- PAS_9; PAS domain
- pfam15836
Location:1012 → 1113
- SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
-
NM_001204798.2 → NP_001191727.1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform d
See identical proteins and their annotated locations for NP_001191727.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and 5' and 3' coding regions compared to variant 1, resulting in a shorter isoform (d) with different N- and C-termini compared to isoform a.
- Source sequence(s)
-
AJ609614, BC001914, BG683210, BQ478289
- UniProtKB/Swiss-Prot
-
Q12809
- Related
-
ENST00000461280.2
- Conserved Domains (3) summary
-
- smart00100
Location:402 → 462
- cNMP; Cyclic nucleotide-monophosphate binding domain
- pfam00520
Location:109 → 328
- Ion_trans; Ion transport protein
- pfam07885
Location:271 → 325
- Ion_trans_2; Ion channel
-
NM_001406753.1 → NP_001393682.1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform e
Status: REVIEWED
- Source sequence(s)
-
AC006343
- UniProtKB/TrEMBL
-
Q15BH2
- Related
-
ENST00000684241.1
-
NM_001406755.1 → NP_001393684.1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform f
Status: REVIEWED
- Source sequence(s)
-
AC006343, AC011234
- UniProtKB/TrEMBL
-
Q86U57
- Related
-
ENST00000713700.1
-
NM_001406756.1 → NP_001393685.1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform g
Status: REVIEWED
- Source sequence(s)
-
AC006343
- UniProtKB/TrEMBL
-
Q86U57
-
NM_001406757.1 → NP_001393686.1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform h
Status: REVIEWED
- Source sequence(s)
-
AC006343, AC011234
- UniProtKB/TrEMBL
-
Q86U57
-
NM_172056.3 → NP_742053.1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform b
See identical proteins and their annotated locations for NP_742053.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2), also known as HERG-USO, differs in the 3' UTR and 3' coding region compared to variant 1, resulting in a shorter isoform (b) with a different C-terminus compared to isoform a.
- Source sequence(s)
-
AC006343, AC011234
- UniProtKB/TrEMBL
- A0A090N7W1, Q86U57
- Related
-
ENST00000532957.5
- Conserved Domains (5) summary
-
- smart00100
Location:742 → 802
- cNMP; Cyclic nucleotide-monophosphate binding domain
- cd00130
Location:41 → 132
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- pfam00520
Location:449 → 668
- Ion_trans; Ion transport protein
- pfam07885
Location:611 → 665
- Ion_trans_2; Ion channel
- pfam13426
Location:29 → 130
- PAS_9; PAS domain
-
NM_172057.3 → NP_742054.1 voltage-gated inwardly rectifying potassium channel KCNH2 isoform c
See identical proteins and their annotated locations for NP_742054.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3), also known as HERG1b, differs in the 5' UTR and 5' coding region compared to variant 1, resulting in a shorter isoform (c) with a different N-terminus compared to isoform a.
- Source sequence(s)
-
AC006343
- Consensus CDS
-
CCDS5911.1
- UniProtKB/TrEMBL
-
A0A090N7X5
- Related
- ENSP00000328531.4, ENST00000330883.9
- Conserved Domains (5) summary
-
- COG0664
Location:396 → 516
- Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
- cd00038
Location:402 → 513
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- pfam00520
Location:109 → 328
- Ion_trans; Ion transport protein
- pfam07885
Location:271 → 325
- Ion_trans_2; Ion channel
- pfam15836
Location:672 → 773
- SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
RNA
-
NR_176254.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC006343, AC011234
-
NR_176255.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC006343
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000007.14 Reference GRCh38.p14 Primary Assembly
- Range
-
150944961..150978321 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047420348.1 → XP_047276304.1 potassium voltage-gated channel subfamily H member 2 isoform X1
- UniProtKB/TrEMBL
-
Q15BH2
-
XM_017012196.2 → XP_016867685.1 potassium voltage-gated channel subfamily H member 2 isoform X3
- UniProtKB/TrEMBL
-
Q15BH2
-
XM_011516185.3 → XP_011514487.1 potassium voltage-gated channel subfamily H member 2 isoform X4
- UniProtKB/TrEMBL
- A0AAQ5BGQ9, Q15BH2
- Related
- ENSP00000519004.1, ENST00000713701.1
- Conserved Domains (5) summary
-
- COG0664
Location:636 → 756
- Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
- cd00038
Location:642 → 753
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- pfam00520
Location:349 → 568
- Ion_trans; Ion transport protein
- pfam07885
Location:511 → 565
- Ion_trans_2; Ion channel
- pfam15836
Location:912 → 1013
- SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
-
XM_017012195.2 → XP_016867684.1 potassium voltage-gated channel subfamily H member 2 isoform X2
- UniProtKB/TrEMBL
-
Q15BH2
- Conserved Domains (1) summary
-
- PLN03192
Location:360 → 797
- PLN03192; Voltage-dependent potassium channel; Provisional
-
XM_047420349.1 → XP_047276305.1 potassium voltage-gated channel subfamily H member 2 isoform X5
Alternate T2T-CHM13v2.0
Genomic
-
NC_060931.1 Alternate T2T-CHM13v2.0
- Range
-
152117824..152151201 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054358168.1 → XP_054214143.1 potassium voltage-gated channel subfamily H member 2 isoform X1
- UniProtKB/TrEMBL
-
Q15BH2
-
XM_054358170.1 → XP_054214145.1 potassium voltage-gated channel subfamily H member 2 isoform X3
- UniProtKB/TrEMBL
-
Q15BH2
-
XM_054358171.1 → XP_054214146.1 potassium voltage-gated channel subfamily H member 2 isoform X4
- UniProtKB/TrEMBL
- A0AAQ5BGQ9, Q15BH2
-
XM_054358169.1 → XP_054214144.1 potassium voltage-gated channel subfamily H member 2 isoform X2
- UniProtKB/TrEMBL
-
Q15BH2
-
XM_054358172.1 → XP_054214147.1 potassium voltage-gated channel subfamily H member 2 isoform X5