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    CCKBR cholecystokinin B receptor [ Homo sapiens (human) ]

    Gene ID: 887, updated on 9-Dec-2024

    Summary

    Official Symbol
    CCKBRprovided by HGNC
    Official Full Name
    cholecystokinin B receptorprovided by HGNC
    Primary source
    HGNC:HGNC:1571
    See related
    Ensembl:ENSG00000110148 MIM:118445; AllianceGenome:HGNC:1571
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GASR; CCK-B; CCK2R; CCK-2R
    Summary
    This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]
    Expression
    Biased expression in stomach (RPKM 4.6), brain (RPKM 2.9) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CCKBR in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6259838..6272127)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6318278..6330559)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6281068..6293357)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FHF complex subunit HOOK interacting protein 1B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3098 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6256113-6256803 Neighboring gene MPRA-validated peak1186 silencer Neighboring gene cyclic nucleotide gated channel subunit alpha 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:6291386-6292585 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:6324771-6325489 Neighboring gene uncharacterized LOC101927825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6340407-6341144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4339 Neighboring gene caveolae associated protein 3 Neighboring gene uncharacterized LOC124902623 Neighboring gene Sharpr-MPRA regulatory region 11421

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables cholecystokinin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cholecystokinin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables gastrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables gastrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables type B gastrin/cholecystokinin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    gastrin/cholecystokinin type B receptor
    Names
    CCK-B receptor
    CCK2 receptor
    cholecystokinin type 2 receptor
    cholecystokinin-2 receptor
    gastrin receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030591.2 RefSeqGene

      Range
      5002..17291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318029.2NP_001304958.1  gastrin/cholecystokinin type B receptor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC022762, AC068733
      Consensus CDS
      CCDS81550.1
      UniProtKB/TrEMBL
      E9PIC8
      Related
      ENSP00000432079.1, ENST00000532715.5
      Conserved Domains (2) summary
      pfam00001
      Location:52306
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:60159
      7tm_4; Olfactory receptor
    2. NM_001363552.2NP_001350481.1  gastrin/cholecystokinin type B receptor isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC022762, AC068733, AF441129
      Consensus CDS
      CCDS86175.1
      Related
      ENSP00000435534.1, ENST00000525462.1
      Conserved Domains (2) summary
      cd14964
      Location:5781
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:55470
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. NM_176875.4NP_795344.1  gastrin/cholecystokinin type B receptor isoform 1

      See identical proteins and their annotated locations for NP_795344.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC022762, AC068733
      Consensus CDS
      CCDS7761.1
      UniProtKB/Swiss-Prot
      A8K7P9, O75824, P32239, Q16144, Q92492, Q96LC6, Q9NYK7, Q9UBV1
      Related
      ENSP00000335544.2, ENST00000334619.7
      Conserved Domains (2) summary
      cd14964
      Location:5781
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:55401
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      6259838..6272127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      6318278..6330559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)