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    TLE4 TLE family member 4, transcriptional corepressor [ Homo sapiens (human) ]

    Gene ID: 7091, updated on 9-Dec-2024

    Summary

    Official Symbol
    TLE4provided by HGNC
    Official Full Name
    TLE family member 4, transcriptional corepressorprovided by HGNC
    Primary source
    HGNC:HGNC:11840
    See related
    Ensembl:ENSG00000106829 MIM:605132; AllianceGenome:HGNC:11840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI); E(spl)
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 39.3), bone marrow (RPKM 12.0) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TLE4 in Genome Data Viewer
    Location:
    9q21.31
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (79571965..79726882)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (91730341..91885229)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (82186880..82341797)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19968 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:82115206-82115783 Neighboring gene lncRNA regulator of Akt signaling associated with HCC and RCC Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19971 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:82187809-82188421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19974 Neighboring gene VISTA enhancer hs1078 Neighboring gene uncharacterized LOC124902329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:82267149-82267908 Neighboring gene VISTA enhancer hs1360 Neighboring gene NANOG hESC enhancer GRCh37_chr9:82346165-82346666 Neighboring gene NANOG hESC enhancer GRCh37_chr9:82380198-82380813 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:82449531-82450161 Neighboring gene long intergenic non-protein coding RNA 1507 Neighboring gene ankyrin repeat domain-containing protein 36B-like Neighboring gene uncharacterized LOC105376101 Neighboring gene nuclear pore associated protein 1 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.
    EBI GWAS Catalog
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    EBI GWAS Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog
    Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transducin-like enhancer protein 4
    Names
    B lymphocyte gene 1
    enhancer of split groucho 4
    groucho-related protein 4
    transducin like enhancer of split 4
    transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
    transducin-like enhancer of split 4, homolog of Drosophila E(sp1)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282748.2NP_001269677.1  transducin-like enhancer protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001269677.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL353813, AL358975, AL445252
      Consensus CDS
      CCDS65069.1
      UniProtKB/Swiss-Prot
      Q04727
      Related
      ENSP00000365720.4, ENST00000376537.8
      Conserved Domains (4) summary
      COG2319
      Location:511803
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:518802
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8138
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:522561
      7WD40; WD40 repeat [structural motif]
    2. NM_001282749.2NP_001269678.1  transducin-like enhancer protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001269678.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AL353813, AL358975
      Consensus CDS
      CCDS65070.1
      UniProtKB/Swiss-Prot
      Q04727
      Related
      ENSP00000265284.6, ENST00000265284.10
      Conserved Domains (4) summary
      COG2319
      Location:454746
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:461745
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8109
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:465504
      7WD40; WD40 repeat [structural motif]
    3. NM_001282753.2NP_001269682.1  transducin-like enhancer protein 4 isoform 4

      See identical proteins and their annotated locations for NP_001269682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 4 which is shorter than isoform 1.
      Source sequence(s)
      AL353813, AL358975, AL445252
      Consensus CDS
      CCDS75851.1
      UniProtKB/Swiss-Prot
      Q04727
      Related
      ENSP00000365727.4, ENST00000376544.7
      Conserved Domains (3) summary
      cd00200
      Location:417701
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:421460
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8138
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    4. NM_001282760.2NP_001269689.1  transducin-like enhancer protein 4 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate exon in the 5' UTR and lacks an alternate in-frame exon in the coding region which results in the use of a downstream start codon compared to variant 1. It encodes isoform 5 which has a shorter N-terminus compared the isoform 1.
      Source sequence(s)
      AL353813, AL358975, AL445252
      Conserved Domains (3) summary
      COG2319
      Location:364650
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:365649
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:369408
      7WD40; WD40 repeat [structural motif]
    5. NM_001351541.2NP_001338470.1  transducin-like enhancer protein 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975, AL445252
      Conserved Domains (3) summary
      cd00200
      Location:499783
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:503542
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8151
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    6. NM_001351542.2NP_001338471.1  transducin-like enhancer protein 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975, AL445252
      Conserved Domains (3) summary
      cd00200
      Location:487771
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:491530
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8139
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    7. NM_001351543.2NP_001338472.1  transducin-like enhancer protein 4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AK296342, AL353813, BC059405, DB284195, HY012218, HY054961
      Consensus CDS
      CCDS94424.1
      UniProtKB/TrEMBL
      A0A994J7T6
      Related
      ENSP00000516378.1, ENST00000706431.1
      Conserved Domains (3) summary
      cd00200
      Location:485769
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:489528
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10137
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    8. NM_001351546.2NP_001338475.1  transducin-like enhancer protein 4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AK296342, AL353813, BC059405, HY012218, HY054961
      Conserved Domains (3) summary
      cd00200
      Location:484768
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:488527
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10136
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    9. NM_001351547.2NP_001338476.1  transducin-like enhancer protein 4 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AK296342, AL353813, HY012218
      Conserved Domains (3) summary
      cd00200
      Location:469753
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:473512
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10121
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    10. NM_001351550.2NP_001338479.1  transducin-like enhancer protein 4 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975, AL445252
      Conserved Domains (3) summary
      cd00200
      Location:466750
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:470509
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8118
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    11. NM_001351552.2NP_001338481.1  transducin-like enhancer protein 4 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975, AL445252
      Conserved Domains (3) summary
      cd00200
      Location:465749
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:469508
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8117
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    12. NM_001351556.2NP_001338485.1  transducin-like enhancer protein 4 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AK296342, AL353813, BC059405, HY012218, HY054961
      Conserved Domains (3) summary
      cd00200
      Location:463747
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:467506
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10115
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    13. NM_001351558.2NP_001338487.1  transducin-like enhancer protein 4 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975
      Conserved Domains (3) summary
      cd00200
      Location:462746
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:466505
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8103
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    14. NM_001351560.2NP_001338489.1  transducin-like enhancer protein 4 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AK296342, AL353813, BI462045, HY012218, HY054961
      Conserved Domains (3) summary
      cd00200
      Location:460744
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:464503
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10101
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    15. NM_001351562.2NP_001338491.1  transducin-like enhancer protein 4 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975
      Conserved Domains (4) summary
      cd00200
      Location:410694
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:414453
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8109
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl26464
      Location:239316
      Atrophin-1; Atrophin-1 family
    16. NM_001351563.2NP_001338492.1  transducin-like enhancer protein 4 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AK296342, AL353813, BI462045, BU428571, HY012218, HY054961
      Conserved Domains (3) summary
      cd00200
      Location:408692
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:412451
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10107
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    17. NM_001351564.2NP_001338493.1  transducin-like enhancer protein 4 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AL353813, AL358975
      Conserved Domains (3) summary
      cd00200
      Location:392676
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:396435
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8109
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    18. NM_007005.6NP_008936.2  transducin-like enhancer protein 4 isoform 3

      See identical proteins and their annotated locations for NP_008936.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
      Source sequence(s)
      AL353813, AL358975, AL445252
      Consensus CDS
      CCDS43837.1
      UniProtKB/Swiss-Prot
      F8W6T6, Q04727, Q3ZCS1, Q5T1Y2, Q6PCB3, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9
      Related
      ENSP00000365735.2, ENST00000376552.8
      Conserved Domains (4) summary
      COG2319
      Location:479771
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:486770
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8138
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:490529
      7WD40; WD40 repeat [structural motif]

    RNA

    1. NR_104239.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL353813, AL358975, AL445252

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      79571965..79726882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518952.2XP_011517254.1  transducin-like enhancer protein 4 isoform X1

      Conserved Domains (4) summary
      COG2319
      Location:578870
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:585869
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:589628
      7WD40; WD40 repeat [structural motif]
    2. XM_006717264.2XP_006717327.1  transducin-like enhancer protein 4 isoform X5

      Conserved Domains (4) summary
      COG2319
      Location:553845
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:560844
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:564603
      7WD40; WD40 repeat [structural motif]
    3. XM_011518958.2XP_011517260.1  transducin-like enhancer protein 4 isoform X8

      Conserved Domains (4) summary
      COG2319
      Location:546838
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:553837
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:557596
      7WD40; WD40 repeat [structural motif]
    4. XM_006717268.2XP_006717331.1  transducin-like enhancer protein 4 isoform X13

      Conserved Domains (4) summary
      COG2319
      Location:521813
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:528812
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:532571
      7WD40; WD40 repeat [structural motif]
    5. XM_011518967.2XP_011517269.1  transducin-like enhancer protein 4 isoform X20

      Conserved Domains (4) summary
      COG2319
      Location:495787
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:502786
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:506545
      7WD40; WD40 repeat [structural motif]
    6. XM_017015074.2XP_016870563.1  transducin-like enhancer protein 4 isoform X24

    7. XM_011518969.2XP_011517271.1  transducin-like enhancer protein 4 isoform X23

      Conserved Domains (4) summary
      COG2319
      Location:477769
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:484768
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:488527
      7WD40; WD40 repeat [structural motif]
    8. XM_047423820.1XP_047279776.1  transducin-like enhancer protein 4 isoform X25

    9. XM_011518956.2XP_011517258.1  transducin-like enhancer protein 4 isoform X6

      Conserved Domains (4) summary
      COG2319
      Location:550842
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:557841
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:561600
      7WD40; WD40 repeat [structural motif]
    10. XM_047423819.1XP_047279775.1  transducin-like enhancer protein 4 isoform X21

    11. XM_011518957.2XP_011517259.1  transducin-like enhancer protein 4 isoform X7

      Conserved Domains (4) summary
      COG2319
      Location:549841
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:556840
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8151
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:560599
      7WD40; WD40 repeat [structural motif]
    12. XM_011518959.2XP_011517261.1  transducin-like enhancer protein 4 isoform X9

      Conserved Domains (4) summary
      COG2319
      Location:537829
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:544828
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8139
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:548587
      7WD40; WD40 repeat [structural motif]
    13. XM_011518965.2XP_011517267.1  transducin-like enhancer protein 4 isoform X18

      Conserved Domains (4) summary
      COG2319
      Location:505797
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:512796
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8139
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:516555
      7WD40; WD40 repeat [structural motif]
    14. XM_047423823.1XP_047279779.1  transducin-like enhancer protein 4 isoform X28

    15. XM_011518960.2XP_011517262.1  transducin-like enhancer protein 4 isoform X10

      Conserved Domains (4) summary
      COG2319
      Location:536828
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:543827
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8138
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:547586
      7WD40; WD40 repeat [structural motif]
    16. XM_011518966.2XP_011517268.1  transducin-like enhancer protein 4 isoform X19

      Conserved Domains (4) summary
      COG2319
      Location:504796
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:511795
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8138
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:515554
      7WD40; WD40 repeat [structural motif]
    17. XM_017015083.2XP_016870572.1  transducin-like enhancer protein 4 isoform X29

    18. XM_011518963.2XP_011517265.1  transducin-like enhancer protein 4 isoform X16

      Conserved Domains (2) summary
      cd00200
      Location:519803
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:523562
      7WD40; WD40 repeat [structural motif]
    19. XM_011518964.2XP_011517266.1  transducin-like enhancer protein 4 isoform X17

      Conserved Domains (4) summary
      COG2319
      Location:511803
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:518802
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8109
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:522561
      7WD40; WD40 repeat [structural motif]
    20. XM_011518955.2XP_011517257.1  transducin-like enhancer protein 4 isoform X4

      Conserved Domains (4) summary
      COG2319
      Location:557849
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:564848
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8112
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:568607
      7WD40; WD40 repeat [structural motif]
    21. XM_011518961.2XP_011517263.1  transducin-like enhancer protein 4 isoform X14

      Conserved Domains (4) summary
      COG2319
      Location:516808
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:523807
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8118
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:527566
      7WD40; WD40 repeat [structural motif]
    22. XM_011518962.2XP_011517264.1  transducin-like enhancer protein 4 isoform X15

      Conserved Domains (4) summary
      COG2319
      Location:515807
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:522806
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8117
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:526565
      7WD40; WD40 repeat [structural motif]
    23. XM_011518968.2XP_011517270.1  transducin-like enhancer protein 4 isoform X22

      Conserved Domains (4) summary
      COG2319
      Location:491783
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:498782
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:883
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:502541
      7WD40; WD40 repeat [structural motif]
    24. XM_047423821.1XP_047279777.1  transducin-like enhancer protein 4 isoform X26

    25. XM_011518954.2XP_011517256.1  transducin-like enhancer protein 4 isoform X3

      Conserved Domains (4) summary
      COG2319
      Location:563855
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:570854
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:8118
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:574613
      7WD40; WD40 repeat [structural motif]
    26. XM_017015068.2XP_016870557.1  transducin-like enhancer protein 4 isoform X12

    27. XM_011518970.4XP_011517272.1  transducin-like enhancer protein 4 isoform X30

      Conserved Domains (2) summary
      pfam03920
      Location:8133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:589628
      7WD40; WD40 repeat [structural motif]
    28. XM_047423824.1XP_047279780.1  transducin-like enhancer protein 4 isoform X31

    29. XM_011518953.3XP_011517255.1  transducin-like enhancer protein 4 isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:576868
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:583867
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:13131
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:587626
      7WD40; WD40 repeat [structural motif]
    30. XM_017015067.2XP_016870556.1  transducin-like enhancer protein 4 isoform X11

    31. XM_047423822.1XP_047279778.1  transducin-like enhancer protein 4 isoform X27

    32. XM_011518972.4XP_011517274.1  transducin-like enhancer protein 4 isoform X32

      Conserved Domains (2) summary
      cd00200
      Location:228512
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:232271
      7WD40; WD40 repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      91730341..91885229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363677.1XP_054219652.1  transducin-like enhancer protein 4 isoform X1

    2. XM_054363681.1XP_054219656.1  transducin-like enhancer protein 4 isoform X5

    3. XM_054363684.1XP_054219659.1  transducin-like enhancer protein 4 isoform X8

    4. XM_054363689.1XP_054219664.1  transducin-like enhancer protein 4 isoform X13

    5. XM_054363696.1XP_054219671.1  transducin-like enhancer protein 4 isoform X20

    6. XM_054363701.1XP_054219676.1  transducin-like enhancer protein 4 isoform X24

    7. XM_054363699.1XP_054219674.1  transducin-like enhancer protein 4 isoform X23

    8. XM_054363702.1XP_054219677.1  transducin-like enhancer protein 4 isoform X25

    9. XM_054363682.1XP_054219657.1  transducin-like enhancer protein 4 isoform X6

    10. XM_054363697.1XP_054219672.1  transducin-like enhancer protein 4 isoform X21

    11. XM_054363683.1XP_054219658.1  transducin-like enhancer protein 4 isoform X7

    12. XM_054363685.1XP_054219660.1  transducin-like enhancer protein 4 isoform X9

    13. XM_054363694.1XP_054219669.1  transducin-like enhancer protein 4 isoform X18

    14. XM_054363705.1XP_054219680.1  transducin-like enhancer protein 4 isoform X28

    15. XM_054363686.1XP_054219661.1  transducin-like enhancer protein 4 isoform X10

    16. XM_054363695.1XP_054219670.1  transducin-like enhancer protein 4 isoform X19

    17. XM_054363706.1XP_054219681.1  transducin-like enhancer protein 4 isoform X29

    18. XM_054363692.1XP_054219667.1  transducin-like enhancer protein 4 isoform X16

    19. XM_054363693.1XP_054219668.1  transducin-like enhancer protein 4 isoform X17

    20. XM_054363680.1XP_054219655.1  transducin-like enhancer protein 4 isoform X4

    21. XM_054363700.1XP_054219675.1  transducin-like enhancer protein 4 isoform X33

    22. XM_054363690.1XP_054219665.1  transducin-like enhancer protein 4 isoform X14

    23. XM_054363691.1XP_054219666.1  transducin-like enhancer protein 4 isoform X15

    24. XM_054363698.1XP_054219673.1  transducin-like enhancer protein 4 isoform X22

    25. XM_054363703.1XP_054219678.1  transducin-like enhancer protein 4 isoform X26

    26. XM_054363679.1XP_054219654.1  transducin-like enhancer protein 4 isoform X3

    27. XM_054363688.1XP_054219663.1  transducin-like enhancer protein 4 isoform X12

    28. XM_054363707.1XP_054219682.1  transducin-like enhancer protein 4 isoform X30

    29. XM_054363708.1XP_054219683.1  transducin-like enhancer protein 4 isoform X31

    30. XM_054363678.1XP_054219653.1  transducin-like enhancer protein 4 isoform X2

    31. XM_054363687.1XP_054219662.1  transducin-like enhancer protein 4 isoform X11

    32. XM_054363704.1XP_054219679.1  transducin-like enhancer protein 4 isoform X27

    33. XM_054363709.1XP_054219684.1  transducin-like enhancer protein 4 isoform X32