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    TMEM176A transmembrane protein 176A [ Homo sapiens (human) ]

    Gene ID: 55365, updated on 27-Nov-2024

    Summary

    Official Symbol
    TMEM176Aprovided by HGNC
    Official Full Name
    transmembrane protein 176Aprovided by HGNC
    Primary source
    HGNC:HGNC:24930
    See related
    Ensembl:ENSG00000002933 MIM:610334; AllianceGenome:HGNC:24930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GS188; MS4B1; HCA112
    Summary
    Predicted to act upstream of or within negative regulation of dendritic cell differentiation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver (RPKM 172.7), kidney (RPKM 114.0) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TMEM176A in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150800769..150805118)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151973144..151977889)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150497857..150502206)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18783 Neighboring gene Bet1 golgi vesicular membrane trafficking protein pseudogene 1 Neighboring gene uncharacterized LOC105375566 Neighboring gene transmembrane protein 176B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150496449-150497148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150497149-150497848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150497849-150498548 Neighboring gene uncharacterized LOC105375567 Neighboring gene uncharacterized LOC124901775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150549187-150549758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150553923-150554766 Neighboring gene amine oxidase copper containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of dendritic cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transmembrane protein 176A
    Names
    hepatocellular carcinoma-associated antigen 112
    likley ortholog of mouse GS188

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018487.3NP_060957.2  transmembrane protein 176A

      See identical proteins and their annotated locations for NP_060957.2

      Status: VALIDATED

      Source sequence(s)
      BC008303
      Consensus CDS
      CCDS5909.1
      UniProtKB/Swiss-Prot
      D3DX00, Q96HP8, Q9NYC7
      UniProtKB/TrEMBL
      A0A090N8H6
      Related
      ENSP00000004103.3, ENST00000004103.8
      Conserved Domains (1) summary
      pfam04103
      Location:56194
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      150800769..150805118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516376.4XP_011514678.1  transmembrane protein 176A isoform X3

      Conserved Domains (1) summary
      pfam04103
      Location:73211
      CD20; CD20-like family
    2. XM_011516378.3XP_011514680.1  transmembrane protein 176A isoform X1

      Conserved Domains (1) summary
      pfam04103
      Location:73203
      CD20; CD20-like family
    3. XM_024446824.2XP_024302592.1  transmembrane protein 176A isoform X2

      Conserved Domains (1) summary
      pfam04103
      Location:56186
      CD20; CD20-like family
    4. XM_047420570.1XP_047276526.1  transmembrane protein 176A isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      151973144..151977889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358578.1XP_054214553.1  transmembrane protein 176A isoform X5

    2. XM_054358579.1XP_054214554.1  transmembrane protein 176A isoform X1

    3. XM_054358580.1XP_054214555.1  transmembrane protein 176A isoform X2