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    BTRC beta-transducin repeat containing E3 ubiquitin protein ligase [ Homo sapiens (human) ]

    Gene ID: 8945, updated on 3-Dec-2024

    Summary

    Official Symbol
    BTRCprovided by HGNC
    Official Full Name
    beta-transducin repeat containing E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:HGNC:1144
    See related
    Ensembl:ENSG00000166167 MIM:603482; AllianceGenome:HGNC:1144
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
    Expression
    Ubiquitous expression in brain (RPKM 11.6), testis (RPKM 7.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BTRC in Genome Data Viewer
    Location:
    10q24.32
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (101354048..101557313)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (102238054..102441353)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103113922..103317070)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103044869-103045778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103045779-103046686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103050677-103051216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103051217-103051756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3911 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103069875-103070404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103070405-103070933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103080866-103081366 Neighboring gene RNA, U2 small nuclear 43, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:103110498-103111697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2720 Neighboring gene small nucleolar RNA U13 Neighboring gene RNA, U2 small nuclear 59, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103201016-103201516 Neighboring gene VISTA enhancer hs326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103320958-103321458 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3913 Neighboring gene NANOG hESC enhancer GRCh37_chr10:103356755-103357323 Neighboring gene DNA polymerase lambda Neighboring gene microRNA 3158-1 Neighboring gene microRNA 3158-2 Neighboring gene deleted in primary ciliary dyskinesia homolog (mouse)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu Vpu requires BTRC to degrade BST2 (tetherin) but does not require BTRC for Vpu-mediated BST2 (tetherin) antagonism PubMed
    vpu HIV-1 Vpu-induced cleavage of IRF3 is largely dependent on the ability of Vpu to interact with beta-TrCP, and mutation of the Vpu phosphorylation sites Ser52 and Ser56 greatly decreases the function of Vpu-induced IRF3 cleavage PubMed
    vpu Interaction of HIV-1 Vpu with betaTrCP is required for Vpu ubiquitination and degradation by the proteasome. Amino acid substitutions at serine's 52 and 56 of Vpu abolish the interaction with betaTrCP PubMed
    vpu Binding of HIV-1 Vpu to beta-TrCP requires two phosphoserine residues on Vpu (amino acids 52 and 56) and results in recruitment of beta-TrCP to cellular membranes PubMed
    vpu Through binding to beta-TrCP, HIV-1 Vpu targets CD4 for degradation in the endoplasmic reticulum and also inhibits IkappaB-alpha degradation as well as NF-kappaB activation PubMed
    vpu Chimeras between the TMD of HIV-1 M Vpu and the cytoplasmic domains of SIVcpzPtt, SIVcpzPts, and SIVgor Vpu proteins are capable of binding to human beta-TrCP PubMed
    vpu Most HIV-1 Vpu proteins from Cameroonian group N viruses are unable to bind beta-TrCP because of lack of a functional beta-TrCP binding site DSGxxS in Vpu PubMed
    vpu HIV-1 Vpu S61A mutant efficiently interacts with endogenous betaTrCP and strongly stabilizes beta-catenin PubMed
    vpu HIV-1 Vpu stabilizes cellular Cdc25A and differentially affects betaTrCP-mediated degradation events at different phases of the cell cycle PubMed
    vpu Poly-ubiquitination of the CD4 cytosolic tail by SCFbeta-TrCP is required for HIV-1 Vpu-induced CD4 degradation PubMed
    vpu HIV-1 Vpu interferes with beta-TrCP to inhibit TNF-alpha-induced activation of NFkappaB PubMed
    vpu The invariant leucine 63 and the valine 68 within the predicted second alpha-helical domain of the HIV-1 Vpu cytoplasmic tail are required for CD4 down-modulation. L63A and V68A mutants still bind CD4 and retain the ability to interact with beta-TrCP1 PubMed
    vpu HIV-1 Vpu and beta-TrCP co-immunoprecipitate with tetherin PubMed
    vpu HIV-1 Vpu expression leads to stabilization and upregulation of p53 via inhibiting association of p53 with beta-TrCP and its subsequent ubiquitination PubMed
    vpu HIV-1 Vpu interacts with BST-2 in the trans-Golgi network or in early endosomes, leading to lysosomal degradation of BST-2. Vpu-mediated downregulation of BST-2 depends on cellular ubiquitination machinery via betaTrCP PubMed
    vpu Co-depletion of beta-TrCP1 and beta-TrCP2 support Vpu's activity to enhance virus release and to downregulate endogenous tetherin in TZM-bl cells PubMed
    vpu HIV-1 Vpu is a strong competitive inhibitor of beta-TrCP and impairs the degradation of SCF-beta-TrCP substrates such as IKBalpha, ATF4 and beta-catenin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC4643

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphorylated amino acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin ligase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mammary gland epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smoothened signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of canonical Wnt signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of proteasomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    F-box/WD repeat-containing protein 1A
    Names
    E3RSIkappaB
    F-box and WD repeats protein beta-TrCP
    F-box and WD-repeat protein 1B
    beta-TrCP1
    epididymis tissue protein Li 2a
    pIkappaBalpha-E3 receptor subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009234.1 RefSeqGene

      Range
      5098..208246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256856.2NP_001243785.1  F-box/WD repeat-containing protein 1A isoform 3

      See identical proteins and their annotated locations for NP_001243785.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AK313417, BC006204, CR749295
      Consensus CDS
      CCDS73183.1
      UniProtKB/TrEMBL
      B7Z3H4, Q68DS0
      Related
      ENSP00000377088.5, ENST00000393441.8
      Conserved Domains (4) summary
      cd00200
      Location:277555
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:280315
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:113151
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:155202
      F-box-like
    2. NM_003939.5NP_003930.1  F-box/WD repeat-containing protein 1A isoform 2

      See identical proteins and their annotated locations for NP_003930.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AF129530, AK313417, BC006204, CR749295
      Consensus CDS
      CCDS7511.1
      UniProtKB/TrEMBL
      B2R8L3
      Related
      ENSP00000385339.2, ENST00000408038.6
      Conserved Domains (4) summary
      cd00200
      Location:267545
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:270305
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:103141
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:145192
      F-box-like
    3. NM_033637.4NP_378663.1  F-box/WD repeat-containing protein 1A isoform 1

      See identical proteins and their annotated locations for NP_378663.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC006204, BC027994, CR749295
      Consensus CDS
      CCDS7512.1
      UniProtKB/Swiss-Prot
      B5MD49, Q5W141, Q5W142, Q9Y213, Q9Y297
      UniProtKB/TrEMBL
      A0A0S2Z4P6, A0A0S2Z507
      Related
      ENSP00000359206.3, ENST00000370187.8
      Conserved Domains (4) summary
      cd00200
      Location:303581
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:306341
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:139177
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:181228
      F-box-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      101354048..101557313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425986.1XP_047281942.1  F-box/WD repeat-containing protein 1A isoform X7

      UniProtKB/TrEMBL
      Q68DS0
    2. XM_006718054.3XP_006718117.1  F-box/WD repeat-containing protein 1A isoform X1

      UniProtKB/TrEMBL
      A0A0S2Z507
      Conserved Domains (5) summary
      COG2319
      Location:417713
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:430708
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:266304
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:308355
      F-box-like; F-box-like
      sd00039
      Location:433468
      7WD40; WD40 repeat [structural motif]
    3. XM_017016870.2XP_016872359.1  F-box/WD repeat-containing protein 1A isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z507
    4. XM_017016874.2XP_016872363.1  F-box/WD repeat-containing protein 1A isoform X5

      UniProtKB/TrEMBL
      B2R8L3
      Conserved Domains (4) summary
      cd00200
      Location:241519
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:244279
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:77115
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:119166
      F-box-like
    5. XM_047425987.1XP_047281943.1  F-box/WD repeat-containing protein 1A isoform X8

    6. XM_017016871.2XP_016872360.1  F-box/WD repeat-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      Q68DS0
      Conserved Domains (4) summary
      cd00200
      Location:285563
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:288323
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:121159
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:163210
      F-box-like
    7. XM_047425983.1XP_047281939.1  F-box/WD repeat-containing protein 1A isoform X4

      UniProtKB/TrEMBL
      Q68DS0
    8. XM_017016873.3XP_016872362.1  F-box/WD repeat-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      Q68DS0
      Conserved Domains (4) summary
      cd00200
      Location:285563
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:288323
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:121159
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:163210
      F-box-like
    9. XM_047425984.1XP_047281940.1  F-box/WD repeat-containing protein 1A isoform X4

      UniProtKB/TrEMBL
      Q68DS0
    10. XM_047425985.1XP_047281941.1  F-box/WD repeat-containing protein 1A isoform X7

      UniProtKB/TrEMBL
      Q68DS0
    11. XM_024448247.2XP_024304015.1  F-box/WD repeat-containing protein 1A isoform X7

      UniProtKB/TrEMBL
      Q68DS0
      Conserved Domains (4) summary
      cd00200
      Location:204482
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:207242
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:4078
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:82129
      F-box-like
    12. XM_011540320.3XP_011538622.1  F-box/WD repeat-containing protein 1A isoform X6

      UniProtKB/TrEMBL
      Q68DS0
      Conserved Domains (5) summary
      COG2319
      Location:222518
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:235513
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:71109
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:113160
      F-box-like; F-box-like
      sd00039
      Location:238273
      7WD40; WD40 repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      102238054..102441353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367115.1XP_054223090.1  F-box/WD repeat-containing protein 1A isoform X8

    2. XM_054367108.1XP_054223083.1  F-box/WD repeat-containing protein 1A isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z507
    3. XM_054367107.1XP_054223082.1  F-box/WD repeat-containing protein 1A isoform X1

      UniProtKB/TrEMBL
      A0A0S2Z507
    4. XM_054367113.1XP_054223088.1  F-box/WD repeat-containing protein 1A isoform X5

      UniProtKB/TrEMBL
      B2R8L3
    5. XM_054367109.1XP_054223084.1  F-box/WD repeat-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      Q68DS0
    6. XM_054367111.1XP_054223086.1  F-box/WD repeat-containing protein 1A isoform X4

      UniProtKB/TrEMBL
      Q68DS0
    7. XM_054367110.1XP_054223085.1  F-box/WD repeat-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      Q68DS0
    8. XM_054367112.1XP_054223087.1  F-box/WD repeat-containing protein 1A isoform X4

      UniProtKB/TrEMBL
      Q68DS0
    9. XM_054367114.1XP_054223089.1  F-box/WD repeat-containing protein 1A isoform X7

      UniProtKB/TrEMBL
      Q68DS0