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    TUG1 taurine up-regulated 1 [ Homo sapiens (human) ]

    Gene ID: 55000, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TUG1provided by HGNC
    Official Full Name
    taurine up-regulated 1provided by HGNC
    Primary source
    HGNC:HGNC:26066
    See related
    Ensembl:ENSG00000253352 MIM:614971; AllianceGenome:HGNC:26066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TI-227H; LINC00080; NCRNA00080
    Summary
    Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within several processes, including mitochondrion organization; photoreceptor cell development; and spermatogenesis. Predicted to be located in mitochondrial membrane and nuclear membrane. Predicted to be active in nucleus. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 36.1), endometrium (RPKM 31.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TUG1 in Genome Data Viewer
    Location:
    22q12.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (30969265..30979395)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31432823..31442955)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31365251..31375381)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein 2 Neighboring gene uncharacterized LOC107985544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18846 Neighboring gene eukaryotic translation initiation factor 4H pseudogene 2 Neighboring gene MORC2 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:31335586-31335801 Neighboring gene MORC family CW-type zinc finger 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13620 Neighboring gene MPRA-validated peak4481 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31439932-31440502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31440503-31441072 Neighboring gene RNA, 7SL, cytoplasmic 633, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13623 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31481712-31482338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31492256-31492830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31492831-31493404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31499788-31500738 Neighboring gene smoothelin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TUG1: a pivotal oncogenic long non-coding RNA of human cancers. Li Z, et al. Cell Prolif, 2016 Aug. PMID 27339553, Free PMC Article
    2. Long non-coding RNA TUG1 promotes cell proliferation and metastasis in human breast cancer. Li T, et al. Breast Cancer, 2017 Jul. PMID 27848085
    3. Long noncoding RNA TUG1 inhibits osteogenesis of bone marrow mesenchymal stem cells via Smad5 after irradiation. Zhang W, et al. Theranostics, 2019. PMID 31149038, Free PMC Article
    4. The Translational Landscape of the Human Heart. van Heesch S, et al. Cell, 2019 Jun 27. PMID 31155234
    5. Long non-coding RNA TUG1 regulates ovarian cancer proliferation and metastasis via affecting epithelial-mesenchymal transition. Kuang D, et al. Exp Mol Pathol, 2016 Oct. PMID 27693324

    See all (235) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Androgen receptor deficiency-induced TUG1 in suppressing ferroptosis to promote benign prostatic hyperplasia through the miR-188-3p/GPX4 signal pathway.
      Title: Androgen receptor deficiency-induced TUG1 in suppressing ferroptosis to promote benign prostatic hyperplasia through the miR-188-3p/GPX4 signal pathway.
    2. M[6]A-mediated upregulation of lncRNA TUG1 in liver cancer cells regulates the antitumor response of CD8[+] T cells and phagocytosis of macrophages.
      Title: M(6)A-mediated upregulation of lncRNA TUG1 in liver cancer cells regulates the antitumor response of CD8(+) T cells and phagocytosis of macrophages.
    3. lncRNA TUG1 transcript levels and psychological disorders: insights into interplay of glycemic index and glycemic load.
      Title: lncRNA TUG1 transcript levels and psychological disorders: insights into interplay of glycemic index and glycemic load.
    4. METTL14-Mediated m6A Modification of TUG1 Represses Ferroptosis in Alzheimer's Disease via Inhibiting GDF15 Ubiquitination.
      Title: METTL14-Mediated m6A Modification of TUG1 Represses Ferroptosis in Alzheimer's Disease via Inhibiting GDF15 Ubiquitination.
    5. Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta.
      Title: Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta.
    6. Aerobic exercise suppresses cognitive injury in patients with Alzheimer's disease by regulating long non-coding RNA TUG1.
      Title: Aerobic exercise suppresses cognitive injury in patients with Alzheimer's disease by regulating long non-coding RNA TUG1.
    7. Increased ferroptosis in leukocytes from preeclamptic women involving the long non-coding taurine upregulated gene 1 (TUG1).
      Title: Increased ferroptosis in leukocytes from preeclamptic women involving the long non-coding taurine upregulated gene 1 (TUG1).
    8. [Long Noncoding RNAs MEG3, TUG1, and hsa-miR-21-3p Are Potential Diagnostic Biomarkers for Coronary Artery Disease].
      Title: [Long Noncoding RNAs MEG3, TUG1, and hsa-miR-21-3p Are Potential Diagnostic Biomarkers for Coronary Artery Disease].
    9. The interaction between MALAT1 and TUG1 with dietary fatty acid quality indices on visceral adiposity index and body adiposity index.
      Title: The interaction between MALAT1 and TUG1 with dietary fatty acid quality indices on visceral adiposity index and body adiposity index.
    10. Interplay of LncRNA TUG1 and TGF-beta/P53 Expression in Colorectal Cancer.
      Title: Interplay of LncRNA TUG1 and TGF-β/P53 Expression in Colorectal Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (206)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20618, MGC46067

    General protein information

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    Preferred Names
    taurine up-regulated 1
    Names
    taurine upregulated gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396518.1 → NP_001383447.1  taurine up-regulated 1

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Consensus CDS
      CCDS93148.1
      UniProtKB/Swiss-Prot
      A0A6I8PU40
      Related
      ENSP00000501406.2, ENST00000644773.3

    2. NM_001398476.1 → NP_001385405.1  taurine up-regulated 1

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Consensus CDS
      CCDS93148.1
      UniProtKB/Swiss-Prot
      A0A6I8PU40

    3. NM_001398477.1 → NP_001385406.1  taurine up-regulated 1

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Consensus CDS
      CCDS93148.1
      UniProtKB/Swiss-Prot
      A0A6I8PU40

    4. NM_001398478.1 → NP_001385407.1  taurine up-regulated 1

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Consensus CDS
      CCDS93148.1
      UniProtKB/Swiss-Prot
      A0A6I8PU40

    5. NM_001398479.1 → NP_001385408.1  taurine up-regulated 1

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Consensus CDS
      CCDS93148.1
      UniProtKB/Swiss-Prot
      A0A6I8PU40
      Related
      ENST00000643071.1

    6. NM_001398480.1 → NP_001385409.1  taurine up-regulated 1

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Consensus CDS
      CCDS93148.1
      UniProtKB/Swiss-Prot
      A0A6I8PU40

    RNA

    1. NR_152867.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Related
      ENST00000646496.1

    2. NR_152868.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004542

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      30969265..30979395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      31432823..31442955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_017903.2: Suppressed sequence

      Description
      NM_017903.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

    2. NR_002323.3: Suppressed sequence

      Description
      NR_002323.3: This RefSeq was removed because it is now thought that this gene does encode a protein.

    3. NR_110493.2: Suppressed sequence

      Description
      NR_110493.2: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version

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