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    cdh11 cadherin 11, type 2, OB-cadherin (osteoblast) [ Danio rerio (zebrafish) ]

    Gene ID: 30461, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cdh11provided by ZNC
    Official Full Name
    cadherin 11, type 2, OB-cadherin (osteoblast)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-170
    See related
    Ensembl:ENSDARG00000021442 AllianceGenome:ZFIN:ZDB-GENE-980526-170
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    vnc; cdhvn
    Summary
    Predicted to enable beta-catenin binding activity and cadherin binding activity. Acts upstream of or within otolith development; retina development in camera-type eye; and retinal ganglion cell axon guidance. Predicted to be located in anchoring junction and plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in cleithrum; nervous system; optic vesicle; and pectoral fin bud. Human ortholog(s) of this gene implicated in Elsahy-Waters syndrome and Teebi hypertelorism syndrome 2. Orthologous to human CDH11 (cadherin 11). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cdh11 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (43760145..43840687, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (43420923..43501915, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108190697 Neighboring gene uncharacterized LOC137496201 Neighboring gene uncharacterized LOC137496103 Neighboring gene cadherin 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ventral neural cadherin, a novel cadherin expressed in a subset of neural tissues in the zebrafish embryo. Franklin JI, et al. Dev Dyn, 1996 Jun. PMID 8725279
    2. Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function. Kikel-Coury NL, et al. PLoS Biol, 2021 Nov. PMID 34793438, Free PMC Article
    3. Cadherin expression in the inner ear of developing zebrafish. Novince ZM, et al. Gene Expr Patterns, 2003 Jun. PMID 12799081
    4. Zebrafish cadherin-11 participates in retinal differentiation and retinotectal axon projection during visual system development. Clendenon SG, et al. Dev Dyn, 2012 Mar. PMID 22247003
    5. Cadherin-1, -2, and -11 expression and cadherin-2 function in the pectoral limb bud and fin of the developing zebrafish. Liu Q, et al. Dev Dyn, 2003 Dec. PMID 14648850

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cdh11 expression in the developing visual system and Cdh11 loss-of-function phenotype illustrates the critical role for differential cadherin activity in visual system differentiation and organization.
      Title: Zebrafish cadherin-11 participates in retinal differentiation and retinotectal axon projection during visual system development.
    2. cadherin-11 is found in the basal region of the embryonic limb buds and in the proximal endoskeleton of the larval pectoral fins
      Title: Cadherin-1, -2, and -11 expression and cadherin-2 function in the pectoral limb bud and fin of the developing zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelium development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within otolith development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-11
    Names
    cadherin 11, osteoblast
    ventral neural cadherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131214.1 → NP_571289.1  cadherin-11 precursor

      See identical proteins and their annotated locations for NP_571289.1

      Status: PROVISIONAL

      Source sequence(s)
      BC163442
      UniProtKB/TrEMBL
      A0A286Y9J7, B3DGG4, B3DGH9
      Related
      ENSDARP00000153918.1, ENSDART00000179758.1
      Conserved Domains (3) summary
      cd11304
      Location:171 → 272
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:87 → 165
      CA; Cadherin repeats
      pfam01049
      Location:645 → 793
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      43760145..43840687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166446.5 → XP_005166503.1  cadherin-11 isoform X1

      See identical proteins and their annotated locations for XP_005166503.1

      UniProtKB/TrEMBL
      A0A286Y9J7, B3DGG4, B3DGH9
      Related
      ENSDARP00000006449.5, ENSDART00000002279.8
      Conserved Domains (3) summary
      cd11304
      Location:171 → 272
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:87 → 165
      CA; Cadherin repeats
      pfam01049
      Location:645 → 793
      Cadherin_C; Cadherin cytoplasmic region
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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