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    dnaja2a DnaJ heat shock protein family (Hsp40) member A2a [ Danio rerio (zebrafish) ]

    Gene ID: 406814, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dnaja2aprovided by ZNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member A2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2884
    See related
    Ensembl:ENSDARG00000104066 AllianceGenome:ZFIN:ZDB-GENE-040426-2884
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dnaja2; zgc:55486; zgc:85775; wu:fb59e04; wu:fb60b08
    Summary
    Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in protein refolding. Predicted to act upstream of or within protein folding and response to heat. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in brain; neurons; and proliferative region. Orthologous to human DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dnaja2a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (41903543..41916505, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (41623470..41635239, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene zgc:92818 Neighboring gene glutamic pyruvate transaminase (alanine aminotransferase) 2 Neighboring gene afadin- and alpha-actinin-binding protein-like Neighboring gene neuropilin and tolloid like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcripts of Kv7.1 and MinK channels and slow delayed rectifier K(+) current (I(Ks)) are expressed in zebrafish (Danio rerio) heart. Abramochkin DV, et al. Pflugers Arch, 2018 Dec. PMID 30116893
    2. Transcript expression of inward rectifier potassium channels of Kir2 subfamily in Arctic marine and freshwater fish species. Hassinen M, et al. J Comp Physiol B, 2019 Dec. PMID 31679058
    3. Cardiac voltage-gated sodium channel expression and electrophysiological characterization of the sodium current in the zebrafish (Danio rerio) ventricle. Haverinen J, et al. Prog Biophys Mol Biol, 2018 Oct. PMID 29655910
    4. Expression of calcium channel transcripts in the zebrafish heart: dominance of T-type channels. Haverinen J, et al. J Exp Biol, 2018 May 20. PMID 29739832
    5. Eye-specific gene expression following embryonic ethanol exposure in zebrafish: roles for heat shock factor 1. Kashyap B, et al. Reprod Toxicol, 2014 Jan. PMID 24355176, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily A member 2a
    Names
    DnaJ (Hsp40) homolog, subfamily A, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213493.1 → NP_998658.1  dnaJ homolog subfamily A member 2a

      See identical proteins and their annotated locations for NP_998658.1

      Status: PROVISIONAL

      Source sequence(s)
      BC048042
      UniProtKB/TrEMBL
      A0A2R8RZG9, B2GT81, Q7ZUP5
      Related
      ENSDARP00000156655.1, ENSDART00000185785.1
      Conserved Domains (4) summary
      cd10719
      Location:144 → 210
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:115 → 341
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:4 → 412
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:9 → 67
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      41903543..41916505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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