gas6 growth arrest-specific 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gas6provided by ZNC
Official Full Name: growth arrest-specific 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7773
See related: Ensembl:ENSDARG00000007804 AllianceGenome:ZFIN:ZDB-GENE-030131-7773
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj34a12; zgc:63860; wu:fj34a12
Summary: Predicted to enable calcium ion binding activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in extracellular region. Is expressed in heart; nervous system; and neural tube. Orthologous to human GAS6 (growth arrest specific 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (312784..338268, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (317605..343089, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 signaling.
Title: Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

Z8613 (e-PCR)
- UniSTS:28455

fj34a12.x1 (e-PCR)
- UniSTS:199139

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth arrest-specific protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199978.1 → NP_956272.1 growth arrest-specific protein 6 precursor

See identical proteins and their annotated locations for NP_956272.1

Status: PROVISIONAL

Source sequence(s)

BC053117

UniProtKB/TrEMBL

Q7T3H4

Related

ENSDARP00000018668.6, ENSDART00000010092.7

Conserved Domains (7) summary

smart00069
Location:21 → 82

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:107 → 143

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:306 → 439

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam02210
Location:493 → 622

Laminin_G_2; Laminin G domain

pfam07645
Location:185 → 225

EGF_CA; Calcium-binding EGF domain

pfam14670
Location:149 → 183

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:225 → 255

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...