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    grtp1a growth hormone regulated TBC protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 406711, updated on 14-Nov-2024

    Summary

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    Official Symbol
    grtp1aprovided by ZNC
    Official Full Name
    growth hormone regulated TBC protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2733
    See related
    Ensembl:ENSDARG00000029936 AllianceGenome:ZFIN:ZDB-GENE-040426-2733
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    grtp1; zgc:73241; wu:fd05h02
    Summary
    Predicted to enable GTPase activator activity. Is expressed in hatching gland and polster. Orthologous to human GRTP1 (growth hormone regulated TBC protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See grtp1a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (184910..191971, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (182623..196792, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene cullin 4A Neighboring gene lysosomal associated membrane protein 1a Neighboring gene ADP-ribosylhydrolase like 1 Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    growth hormone-regulated TBC protein 1-A
    Names
    growth hormone regulated TBC protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213402.1 → NP_998567.1  growth hormone-regulated TBC protein 1-A

      See identical proteins and their annotated locations for NP_998567.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059581
      UniProtKB/Swiss-Prot
      Q6PBU5
      Related
      ENSDARP00000131713.1, ENSDART00000164091.2
      Conserved Domains (1) summary
      smart00164
      Location:84 → 296
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      184910..191971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216707.1 → XP_068072808.1  growth hormone-regulated TBC protein 1-A isoform X1

    2. XM_021470179.2 → XP_021325854.1  growth hormone-regulated TBC protein 1-A isoform X1

      UniProtKB/TrEMBL
      A0A8M9PLU0
      Conserved Domains (1) summary
      pfam00566
      Location:75 → 247
      RabGAP-TBC; Rab-GTPase-TBC domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PBU5.1 GenPept UniProtKB/Swiss-Prot:Q6PBU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials