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    mAcon2 Mitochondrial aconitase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41326, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mAcon2provided by FlyBase
    Official Full Name
    Mitochondrial aconitase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037862
    Locus tag
    Dmel_CG4706
    See related
    AllianceGenome:FB:FBgn0037862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4706; Dmel\CG4706; FBgn0037862
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and aconitate hydratase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head; embryonic/larval midgut; organism; spermatozoon; and testis. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See mAcon2 in Genome Data Viewer
    Location:
    86D4-86D4; 3-50 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11137177..11139742)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6962899..6965464)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Succinate dehydrogenase, subunit C-like Neighboring gene UDP-glycosyltransferase family 35 member C1 Neighboring gene Chemosensory protein A 86a Neighboring gene UDP-glycosyltransferase family 302 member K1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency. Cheng Z, et al. Biochem Biophys Res Commun, 2013 Mar 29. PMID 23438437
    2. ACO2 deficiency increases vulnerability to Parkinson's disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes. Zhu J, et al. Commun Biol, 2023 Nov 25. PMID 38007539, Free PMC Article
    3. Elevating bioavailable iron levels in mitochondria suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila melanogaster. Wan Z, et al. Biochem Biophys Res Commun, 2020 Nov 5. PMID 32873392
    4. Recent origins of sperm genes in Drosophila. Dorus S, et al. Mol Biol Evol, 2008 Oct. PMID 18653731, Free PMC Article
    5. Quality of regulatory elements in Drosophila retrogenes. Bai Y, et al. Genomics, 2009 Jan. PMID 18848618, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACO2 deficiency increases vulnerability to Parkinson's disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes.
      Title: ACO2 deficiency increases vulnerability to Parkinson's disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in sexual reproduction HEP PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space HDA PubMed 
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial aconitase 2
    Names
    CG4706-PA
    m-aconitase
    mAcon2-PA
    NP_650042.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11137177..11139742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141785.3 → NP_650042.2  mitochondrial aconitase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650042.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T4D6, Q9VGT6
      Related
      FBpp0081812
      Conserved Domains (3) summary
      cd01584
      Location:93 → 503
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      TIGR01340
      Location:43 → 772
      aconitase_mito; aconitate hydratase, mitochondrial
      cl00215
      Location:585 → 733
      Aconitase_swivel; Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T4D6 Q8T4D6

    Gene LinkOut

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