Mettl14 Methyltransferase like 14 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mettl14provided by FlyBase
Official Full Name: Methyltransferase like 14provided by FlyBase
Primary source: FLYBASE:FBgn0032016
Locus tag: Dmel_CG7818
See related: AllianceGenome:FB:FBgn0032016
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7818; dKAR4; Dmel\CG7818; dMettl14; mettl14; METTL14
Summary: Enables mRNA (N6-adenosine)-methyltransferase activity. Involved in female sex determination; mRNA methylation; and regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasm and nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in embryonic/larval central nervous system; organism; and ventral neurectoderm. Orthologous to human METTL14 (methyltransferase 14, N6-adenosine-methyltransferase subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8308427..8309961)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8308427..8309961)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

METTL14 Regulates Intestine Cellular Senescence through m[6]A Modification of Lamin B Receptor.
Title: METTL14 Regulates Intestine Cellular Senescence through m(6)A Modification of Lamin B Receptor.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in female sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA N6-methyladenosine methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA N6-methyladenosine methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info