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    ZNF782 zinc finger protein 782 [ Homo sapiens (human) ]

    Gene ID: 158431, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF782provided by HGNC
    Official Full Name
    zinc finger protein 782provided by HGNC
    Primary source
    HGNC:HGNC:33110
    See related
    Ensembl:ENSG00000196597 AllianceGenome:HGNC:33110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis (RPKM 1.8), thyroid (RPKM 1.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF782 in Genome Data Viewer
    Location:
    9q22.33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (96816164..96933806, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (108957160..109105571, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (99578551..99616796, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene makorin ring finger protein 10, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20091 Neighboring gene zinc finger protein 510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20093 Neighboring gene Sharpr-MPRA regulatory region 3853 Neighboring gene cyclin Y like 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28655 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:99636216-99637415 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:99646252-99647451 Neighboring gene proline-rich nuclear receptor coactivator 2-like Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:99680095-99680594 Neighboring gene NANOG hESC enhancer GRCh37_chr9:99680882-99681400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:99686833-99687376 Neighboring gene prothymosin alpha pseudogene 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:99693219-99694104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:99694105-99694990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99697969-99698597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99698598-99699226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99701353-99701853 Neighboring gene NUT family member 2G Neighboring gene major facilitator superfamily domain containing 14C, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr9:99739460-99739668 Neighboring gene yrdC N(6)-threonylcarbamoyltransferase domain containing pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99750992-99751492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20097 Neighboring gene cathepsin V

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci. Lei SF, et al. Hum Genet, 2009 Feb. PMID 19030899, Free PMC Article
    2. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. Moutaoufik MT, et al. iScience, 2019 Sep 27. PMID 31536960, Free PMC Article
    3. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
    4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The present results suggest that the genomic region containing the ZNP510 and ZNP782 genes is an ethnic specific locus associated with stature variation in Chinese.
      Title: Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci.
    2. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16636

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 782

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001662.3 → NP_001001662.1  zinc finger protein 782 isoform a

      See identical proteins and their annotated locations for NP_001001662.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK131468, AL158827, AL540705
      Consensus CDS
      CCDS35075.1
      UniProtKB/Swiss-Prot
      B2RNR0, Q6ZMW2
      Related
      ENSP00000419397.1, ENST00000481138.6
      Conserved Domains (5) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:392 → 697
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:592 → 612
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:660 → 685
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001346991.2 → NP_001333920.1  zinc finger protein 782 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL158827
      Consensus CDS
      CCDS35075.1
      UniProtKB/Swiss-Prot
      B2RNR0, Q6ZMW2

    3. NM_001346993.2 → NP_001333922.1  zinc finger protein 782 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AL158827

    4. NM_001346995.2 → NP_001333924.1  zinc finger protein 782 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AL158827
      Conserved Domains (3) summary
      COG5048
      Location:300 → 555
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:460 → 480
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:276 → 300
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      96816164..96933806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422874.1 → XP_047278830.1  zinc finger protein 782 isoform X3

    2. XM_011518315.3 → XP_011516617.1  zinc finger protein 782 isoform X1

      See identical proteins and their annotated locations for XP_011516617.1

      UniProtKB/Swiss-Prot
      B2RNR0, Q6ZMW2
      Related
      ENSP00000440624.2, ENST00000535338.5
      Conserved Domains (5) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:392 → 697
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:592 → 612
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:660 → 685
      zf-H2C2_2; Zinc-finger double domain

    3. XM_047422870.1 → XP_047278826.1  zinc finger protein 782 isoform X1

      UniProtKB/Swiss-Prot
      B2RNR0, Q6ZMW2

    4. XM_011518320.3 → XP_011516622.1  zinc finger protein 782 isoform X2

      See identical proteins and their annotated locations for XP_011516622.1

      Conserved Domains (5) summary
      smart00349
      Location:3 → 61
      KRAB; krueppel associated box
      COG5048
      Location:386 → 691
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586 → 606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3 → 41
      KRAB; KRAB box
      pfam13465
      Location:654 → 679
      zf-H2C2_2; Zinc-finger double domain

    5. XM_047422872.1 → XP_047278828.1  zinc finger protein 782 isoform X2

    6. XM_011518318.4 → XP_011516620.1  zinc finger protein 782 isoform X1

      See identical proteins and their annotated locations for XP_011516620.1

      UniProtKB/Swiss-Prot
      B2RNR0, Q6ZMW2
      Conserved Domains (5) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:392 → 697
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:592 → 612
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:660 → 685
      zf-H2C2_2; Zinc-finger double domain

    7. XM_047422871.1 → XP_047278827.1  zinc finger protein 782 isoform X2

    8. XM_017014343.3 → XP_016869832.1  zinc finger protein 782 isoform X2

      Conserved Domains (5) summary
      smart00349
      Location:3 → 61
      KRAB; krueppel associated box
      COG5048
      Location:386 → 691
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:586 → 606
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3 → 41
      KRAB; KRAB box
      pfam13465
      Location:654 → 679
      zf-H2C2_2; Zinc-finger double domain

    9. XM_047422873.1 → XP_047278829.1  zinc finger protein 782 isoform X3

    10. XM_024447431.2 → XP_024303199.1  zinc finger protein 782 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:300 → 555
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:460 → 480
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:276 → 300
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_007061256.1 RNA Sequence

    2. XR_007061255.1 RNA Sequence

    3. XR_007061254.1 RNA Sequence

    4. XR_007061253.1 RNA Sequence

    5. XR_001746208.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      108957160..109105571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362170.1 → XP_054218145.1  zinc finger protein 782 isoform X3

    2. XM_054362164.1 → XP_054218139.1  zinc finger protein 782 isoform X1

    3. XM_054362163.1 → XP_054218138.1  zinc finger protein 782 isoform X1

    4. XM_054362162.1 → XP_054218137.1  zinc finger protein 782 isoform X1

    5. XM_054362168.1 → XP_054218143.1  zinc finger protein 782 isoform X3

    6. XM_054362167.1 → XP_054218142.1  zinc finger protein 782 isoform X2

    7. XM_054362166.1 → XP_054218141.1  zinc finger protein 782 isoform X2

    8. XM_054362161.1 → XP_054218136.1  zinc finger protein 782 isoform X1

    9. XM_054362165.1 → XP_054218140.1  zinc finger protein 782 isoform X2

    10. XM_054362169.1 → XP_054218144.1  zinc finger protein 782 isoform X3

    RNA

    1. XR_008487953.1 RNA Sequence

    2. XR_008487952.1 RNA Sequence

    3. XR_008487951.1 RNA Sequence

    4. XR_008487950.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZMW2.1 GenPept UniProtKB/Swiss-Prot:Q6ZMW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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