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    ARL4C ARF like GTPase 4C [ Homo sapiens (human) ]

    Gene ID: 10123, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ARL4Cprovided by HGNC
    Official Full Name
    ARF like GTPase 4Cprovided by HGNC
    Primary source
    HGNC:HGNC:698
    See related
    Ensembl:ENSG00000188042 MIM:604787; AllianceGenome:HGNC:698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAK; ARL7
    Summary
    ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lymph node (RPKM 30.2), spleen (RPKM 30.0) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARL4C in Genome Data Viewer
    Location:
    2q37.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (234493041..234497081, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (234982177..234986217, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (235401685..235405725, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17354 Neighboring gene long intergenic non-protein coding RNA 1891 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12473 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12474 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:235405987-235406760 Neighboring gene CRISPRi-validated cis-regulatory element chr2.7113 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:235471377-235472120 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:235505034-235505574 Neighboring gene uncharacterized LOC105373936 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:235505575-235506115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:235512165-235513116 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:235531433-235532632 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:235549687-235550294 Neighboring gene NANOG hESC enhancer GRCh37_chr2:235570023-235570546 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:235596500-235597125 Neighboring gene Sharpr-MPRA regulatory region 2610 Neighboring gene long intergenic non-protein coding RNA 1173 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:235602982-235604181 Neighboring gene NANOG hESC enhancer GRCh37_chr2:235619073-235619654

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer. Kanai R, et al. BMC Cancer, 2023 May 26. PMID 37237373, Free PMC Article
    2. ARL4C depletion suppresses the resistance of ovarian cancer to carboplatin by disrupting cholesterol transport and autophagy via notch-RBP-Jκ-H3K4Me3-OSBPL5. Yang J, et al. Hum Exp Toxicol, 2022 Jan-Dec. PMID 36366750
    3. ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export. Engel T, et al. FEBS Lett, 2004 May 21. PMID 15147902
    4. Arl4c expression in colorectal and lung cancers promotes tumorigenesis and may represent a novel therapeutic target. Fujii S, et al. Oncogene, 2015 Sep 10. PMID 25486429
    5. Clinical and prognostic significance of Arl4c expression in colorectal cancer. Chen X, et al. Cancer Biomark, 2016. PMID 26756615

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stepwise activation of p63 and the MEK/ERK pathway induces the expression of ARL4C to promote oral squamous cell carcinoma cell proliferation.
      Title: Stepwise activation of p63 and the MEK/ERK pathway induces the expression of ARL4C to promote oral squamous cell carcinoma cell proliferation.
    2. ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer.
      Title: ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer.
    3. ARL4C depletion suppresses the resistance of ovarian cancer to carboplatin by disrupting cholesterol transport and autophagy via notch-RBP-Jkappa-H3K4Me3-OSBPL5.
      Title: ARL4C depletion suppresses the resistance of ovarian cancer to carboplatin by disrupting cholesterol transport and autophagy via notch-RBP-Jκ-H3K4Me3-OSBPL5.
    4. Identification of Neural Progenitor Cell-associated Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for Prognosis of Glioma.
      Title: Identification of Neural Progenitor Cell-associated Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for Prognosis of Glioma.
    5. RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation.
      Title: RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation.
    6. ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments.
      Title: ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments.
    7. High ARL4C expression is associated with Peritoneal Dissemination in Gastric Cancer.
      Title: ASO Author Reflections: ARL4C and Peritoneal Dissemination in Gastric Cancer.
    8. ARL4C is involved in the initiation of the premalignant stage.
      Title: ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target.
    9. ARL4C antisense oligonucleotides (ASO) accumulated in cancer cells more efficiently than the surrounding normal cells in the liver and decreased ARL4C expression in the tumor. These results suggest that ARL4C ASO represents a novel targeted nucleic acid medicine for the treatment of primary and metastatic liver cancers.
      Title: Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth.
    10. ARL4C stabilized by AKT/mTOR pathway promotes the invasiveness of PTEN-deficient glioblastoma cells.
      Title: ARL4C stabilized by AKT/mTOR pathway promotes the invasion of PTEN-deficient primary human glioblastoma.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
    EBI GWAS Catalog
    Genome-wide association study of pancreatic cancer in Japanese population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HTP PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 4C
    Names
    ADP ribosylation factor like GTPase 4C
    ADP ribosylation factor-like protein 7
    ADP-ribosylation factor-like 4C
    ADP-ribosylation factor-like 7
    ADP-ribosylation factor-like protein LAK

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282431.2 → NP_001269360.1  ADP-ribosylation factor-like protein 4C isoform 1

      See identical proteins and their annotated locations for NP_001269360.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1)
      Source sequence(s)
      AC105145, AJ579850, BC089043
      Consensus CDS
      CCDS63169.1
      UniProtKB/Swiss-Prot
      P56559
      Related
      ENSP00000339754.3, ENST00000339728.6
      Conserved Domains (1) summary
      cd04152
      Location:11 → 192
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    2. NM_005737.3 → NP_005728.2  ADP-ribosylation factor-like protein 4C isoform 2

      See identical proteins and their annotated locations for NP_005728.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional internal segment which results in alternate stop codon compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      BC001051, BM541491, BM904613, BU844902, CA413100, CD358707, Y17804
      Consensus CDS
      CCDS2512.1
      UniProtKB/Swiss-Prot
      P56559, Q4A519, Q53R10, Q9BVN1, Q9UQ34
      Related
      ENSP00000375057.2, ENST00000390645.2
      Conserved Domains (1) summary
      cd04152
      Location:11 → 192
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      234493041..234497081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      234982177..234986217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56559.1 GenPept UniProtKB/Swiss-Prot:P56559

    Gene LinkOut

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