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    ZIK1 zinc finger protein interacting with K protein 1 [ Homo sapiens (human) ]

    Gene ID: 284307, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZIK1provided by HGNC
    Official Full Name
    zinc finger protein interacting with K protein 1provided by HGNC
    Primary source
    HGNC:HGNC:33104
    See related
    Ensembl:ENSG00000171649 AllianceGenome:HGNC:33104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF762
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thyroid (RPKM 2.1), testis (RPKM 1.9) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZIK1 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57584145..57593890)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60681073..60690819)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58095513..58105258)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58070497-58071361 Neighboring gene uncharacterized LOC124904781 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:58071339-58072538 Neighboring gene zinc finger protein 416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58095022-58095553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15149 Neighboring gene zinc finger protein 530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11077 Neighboring gene zinc finger protein 134

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein. Denisenko ON, et al. J Biol Chem, 1996 Nov 1. PMID 8910362
    2. Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein-protein interactions in the human cell. Bartolec TK, et al. Proc Natl Acad Sci U S A, 2023 Apr 25. PMID 37071682, Free PMC Article
    3. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053
    4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119699, MGC119700, MGC119701

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein interacting with ribonucleoprotein K
    Names
    zinc finger protein 762
    zinc finger protein interacting with K protein 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010879.4 → NP_001010879.2  zinc finger protein interacting with ribonucleoprotein K isoform 1

      See identical proteins and their annotated locations for NP_001010879.2

      Status: VALIDATED

      Source sequence(s)
      AC003682, AK092538, BC103958
      Consensus CDS
      CCDS33135.1
      UniProtKB/Swiss-Prot
      O43339, Q3SY51, Q3SY52, Q3SY53
      Related
      ENSP00000472867.1, ENST00000597850.2
      Conserved Domains (5) summary
      smart00349
      Location:27 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:381 → 401
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:27 → 66
      KRAB; KRAB box
      pfam13465
      Location:394 → 418
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001321145.2 → NP_001308074.1  zinc finger protein interacting with ribonucleoprotein K isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC003682, AK128340, BC103957, DB480028
      Consensus CDS
      CCDS82407.1
      UniProtKB/TrEMBL
      F5H435
      Related
      ENSP00000438487.1, ENST00000536878.6
      Conserved Domains (5) summary
      smart00349
      Location:14 → 55
      KRAB; krueppel associated box
      COG5048
      Location:256 → 436
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:368 → 388
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:381 → 405
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001321146.2 → NP_001308075.1  zinc finger protein interacting with ribonucleoprotein K isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC003682, BC103957, BC103959, DB277510
      Consensus CDS
      CCDS82408.1
      UniProtKB/Swiss-Prot
      Q3SY52
      Related
      ENSP00000468937.1, ENST00000599456.1
      Conserved Domains (3) summary
      COG5048
      Location:214 → 394
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:326 → 346
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:339 → 363
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001321147.2 → NP_001308076.1  zinc finger protein interacting with ribonucleoprotein K isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC003682, BC103957, DA101277, DN993640
      UniProtKB/Swiss-Prot
      Q3SY52
      Conserved Domains (2) summary
      COG5048
      Location:166 → 346
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:278 → 298
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57584145..57593890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526762.2 → XP_011525064.1  zinc finger protein interacting with ribonucleoprotein K isoform X2

      Conserved Domains (5) summary
      smart00349
      Location:8 → 49
      KRAB; krueppel associated box
      COG5048
      Location:250 → 430
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:362 → 382
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:375 → 399
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011526766.3 → XP_011525068.1  zinc finger protein interacting with ribonucleoprotein K isoform X4

      See identical proteins and their annotated locations for XP_011525068.1

      UniProtKB/Swiss-Prot
      Q3SY52
      Conserved Domains (3) summary
      COG5048
      Location:214 → 394
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:326 → 346
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:339 → 363
      zf-H2C2_2; Zinc-finger double domain

    3. XM_011526765.3 → XP_011525067.1  zinc finger protein interacting with ribonucleoprotein K isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:233 → 413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:345 → 365
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:358 → 382
      zf-H2C2_2; Zinc-finger double domain

    4. XM_011526761.2 → XP_011525063.1  zinc finger protein interacting with ribonucleoprotein K isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:255 → 435
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:367 → 387
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:20 → 52
      KRAB; KRAB box
      pfam13465
      Location:380 → 404
      zf-H2C2_2; Zinc-finger double domain

    5. XM_011526767.4 → XP_011525069.1  zinc finger protein interacting with ribonucleoprotein K isoform X5

      See identical proteins and their annotated locations for XP_011525069.1

      UniProtKB/Swiss-Prot
      Q3SY52
      Conserved Domains (2) summary
      COG5048
      Location:166 → 346
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:278 → 298
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60681073..60690819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320585.1 → XP_054176560.1  zinc finger protein interacting with ribonucleoprotein K isoform X2

    2. XM_054320587.1 → XP_054176562.1  zinc finger protein interacting with ribonucleoprotein K isoform X4

    3. XM_054320586.1 → XP_054176561.1  zinc finger protein interacting with ribonucleoprotein K isoform X3

    4. XM_054320584.1 → XP_054176559.1  zinc finger protein interacting with ribonucleoprotein K isoform X1

    5. XM_054320588.1 → XP_054176563.1  zinc finger protein interacting with ribonucleoprotein K isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3SY52.1 GenPept UniProtKB/Swiss-Prot:Q3SY52

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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