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    SLC39A10 solute carrier family 39 member 10 [ Homo sapiens (human) ]

    Gene ID: 57181, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SLC39A10provided by HGNC
    Official Full Name
    solute carrier family 39 member 10provided by HGNC
    Primary source
    HGNC:HGNC:20861
    See related
    Ensembl:ENSG00000196950 MIM:608733; AllianceGenome:HGNC:20861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZIP10; LZT-Hs2
    Summary
    Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in thyroid (RPKM 12.9), brain (RPKM 12.5) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC39A10 in Genome Data Viewer
    Location:
    2q32.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (195613029..195737700)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (196097362..196222040)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (196521682..196602424)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:196434945-196435535 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:196450653-196451242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:196452793-196453292 Neighboring gene long intergenic non-protein coding RNA 1827 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:196477499-196478360 Neighboring gene adenosylhomocysteinase pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16889 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12199 Neighboring gene RNA, U6 small nuclear 915, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:196559503-196560702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:196569194-196569694 Neighboring gene uncharacterized LOC107985972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:196608945-196609445 Neighboring gene dynein axonemal heavy chain 7 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:196652546-196653745 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:196722945-196724144 Neighboring gene E2F transcription factor 3 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Possible involvement of zinc transporter ZIP10 in atopic dermatitis. Nakajima K, et al. J Dermatol, 2020 Feb. PMID 31875492
    2. Association between ZIP10 gene expression and tumor aggressiveness in renal cell carcinoma. Pal D, et al. Gene, 2014 Nov 15. PMID 25200496
    3. ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway. Li H, et al. J Exp Clin Cancer Res, 2021 Oct 27. PMID 34706747, Free PMC Article
    4. Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity. Polesel M, et al. Biometals, 2023 Feb. PMID 36454509, Free PMC Article
    5. SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways. Ren X, et al. Exp Mol Med, 2023 Aug. PMID 37524874, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways.
      Title: SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways.
    2. The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling.
      Title: The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling.
    3. Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity.
      Title: Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity.
    4. ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway.
      Title: ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway.
    5. The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.
      Title: The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.
    6. Possible involvement of zinc transporter ZIP10 in atopic dermatitis.
      Title: Possible involvement of zinc transporter ZIP10 in atopic dermatitis.
    7. ZIP10 is found in the proximal tubules collecting duct system and has a role in renal zinc transport.
      Title: Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn(2+) transporter.
    8. Slc39a10 plays a role in promoting the survival of macrophages through a Zn/p53-dependent axis in response to inflammatory stimuli.
      Title: Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival.
    9. A significant correlation between ZIP10 mRNA expressions with aggressiveness of RCC.
      Title: Association between ZIP10 gene expression and tumor aggressiveness in renal cell carcinoma.
    10. Zinc and its transporters, ZIP6 and ZIP10, are required for the breast cancer cells motility stimulated with high glucose level, such as in diabetes.
      Title: High glucose level promotes migration behavior of breast cancer cells through zinc and its transporters.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC39A10 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of solute carrier family 39 (zinc transporter), member 10 (SLC39A10) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31108, MGC126565, MGC138428, DKFZp781L10106

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monoatomic cation:bicarbonate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular monoatomic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of B cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc transporter ZIP10
    Names
    ZIP-10
    ZRT/IRT-like protein 10
    solute carrier family 39 (metal ion transporter), member 10
    solute carrier family 39 (zinc transporter), member 10
    zinc transporter 10
    zrt- and Irt-like protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127257.2 → NP_001120729.1  zinc transporter ZIP10 precursor

      See identical proteins and their annotated locations for NP_001120729.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC013274, AI693720, CR749813
      Consensus CDS
      CCDS33353.1
      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
      Related
      ENSP00000386766.3, ENST00000409086.7
      Conserved Domains (1) summary
      pfam02535
      Location:404 → 819
      Zip; ZIP Zinc transporter

    2. NM_020342.3 → NP_065075.1  zinc transporter ZIP10 precursor

      See identical proteins and their annotated locations for NP_065075.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC013274, AI693720, AK291241
      Consensus CDS
      CCDS33353.1
      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
      Related
      ENSP00000352655.5, ENST00000359634.10
      Conserved Domains (1) summary
      pfam02535
      Location:404 → 819
      Zip; ZIP Zinc transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      195613029..195737700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511504.3 → XP_011509806.1  zinc transporter ZIP10 isoform X4

      See identical proteins and their annotated locations for XP_011509806.1

      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
      Conserved Domains (1) summary
      pfam02535
      Location:404 → 819
      Zip; ZIP Zinc transporter

    2. XM_005246689.5 → XP_005246746.3  zinc transporter ZIP10 isoform X1

    3. XM_047445143.1 → XP_047301099.1  zinc transporter ZIP10 isoform X4

      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1

    4. XM_011511507.3 → XP_011509809.2  zinc transporter ZIP10 isoform X5

    5. XM_017004523.2 → XP_016860012.2  zinc transporter ZIP10 isoform X6

    6. XM_047445144.1 → XP_047301100.1  zinc transporter ZIP10 isoform X4

      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1

    7. XM_047445141.1 → XP_047301097.1  zinc transporter ZIP10 isoform X2

    8. XM_047445142.1 → XP_047301098.1  zinc transporter ZIP10 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      196097362..196222040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343084.1 → XP_054199059.1  zinc transporter ZIP10 isoform X4

      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1

    2. XM_054343085.1 → XP_054199060.1  zinc transporter ZIP10 isoform X4

      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1

    3. XM_054343081.1 → XP_054199056.1  zinc transporter ZIP10 isoform X7

    4. XM_054343087.1 → XP_054199062.1  zinc transporter ZIP10 isoform X8

    5. XM_054343088.1 → XP_054199063.1  zinc transporter ZIP10 isoform X9

    6. XM_054343086.1 → XP_054199061.1  zinc transporter ZIP10 isoform X4

      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1

    7. XM_054343082.1 → XP_054199057.1  zinc transporter ZIP10 isoform X2

    8. XM_054343083.1 → XP_054199058.1  zinc transporter ZIP10 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULF5.2 GenPept UniProtKB/Swiss-Prot:Q9ULF5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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