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    PPDPFL pancreatic progenitor cell differentiation and proliferation factor like [ Homo sapiens (human) ]

    Gene ID: 492307, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PPDPFLprovided by HGNC
    Official Full Name
    pancreatic progenitor cell differentiation and proliferation factor likeprovided by HGNC
    Primary source
    HGNC:HGNC:31745
    See related
    Ensembl:ENSG00000168333 AllianceGenome:HGNC:31745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C8orf22
    Summary
    Predicted to be involved in cell differentiation. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in prostate (RPKM 1.7), esophagus (RPKM 0.6) and 1 other tissue See more
    Orthologs
    all
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    Genomic context

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    See PPDPFL in Genome Data Viewer
    Location:
    8q11.21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (49054336..49076093)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (49432165..49453922)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (49966895..49988652)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27334 Neighboring gene uncharacterized LOC107986942 Neighboring gene snail family transcriptional repressor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:49930905-49931404 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:50005272-50005851 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:50022257-50023456 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:50041656-50042855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27336 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:50079889-50081088 Neighboring gene uncharacterized LOC105375826 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:50119678-50119830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27338 Neighboring gene Sharpr-MPRA regulatory region 5408 Neighboring gene RN7SK pseudogene 294

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pancreatic progenitor cell differentiation and proliferation factor-like protein
    Names
    exocrine differentiation and proliferation factor-like protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007176.5 → NP_001007177.1  pancreatic progenitor cell differentiation and proliferation factor-like protein isoform a

      See identical proteins and their annotated locations for NP_001007177.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shortest isoform (a).
      Source sequence(s)
      AC044893, BC017981, DA820911
      Consensus CDS
      CCDS47854.1
      UniProtKB/Swiss-Prot
      Q8WWR9
      Related
      ENSP00000382561.4, ENST00000399653.8
      Conserved Domains (1) summary
      pfam15060
      Location:1 → 69
      PPDFL; Differentiation and proliferation regulator

    2. NM_001256596.1 → NP_001243525.1  pancreatic progenitor cell differentiation and proliferation factor-like protein isoform b

      See identical proteins and their annotated locations for NP_001243525.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform b, which has a longer and distinct C-terminus, compared to isoform a. Variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AC044893, BC017981, BG202040
      Consensus CDS
      CCDS59102.1
      UniProtKB/Swiss-Prot
      Q8WWR9
      Related
      ENSP00000430392.1, ENST00000517663.5
      Conserved Domains (1) summary
      pfam15060
      Location:1 → 82
      PPDFL; Differentiation and proliferation regulator

    3. NM_001256597.2 → NP_001243526.1  pancreatic progenitor cell differentiation and proliferation factor-like protein isoform b

      See identical proteins and their annotated locations for NP_001243526.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform b, which has a longer and distinct C-terminus, compared to isoform a. Variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AC044893, BC017981, DA900243
      Consensus CDS
      CCDS59102.1
      UniProtKB/Swiss-Prot
      Q8WWR9
      Related
      ENSP00000428773.1, ENST00000522267.6
      Conserved Domains (1) summary
      pfam15060
      Location:1 → 82
      PPDFL; Differentiation and proliferation regulator

    4. NM_001256598.2 → NP_001243527.1  pancreatic progenitor cell differentiation and proliferation factor-like protein isoform c

      See identical proteins and their annotated locations for NP_001243527.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform c, which has a longer and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC044893, AJ276240, BC017981, DA820911
      Consensus CDS
      CCDS59101.1
      UniProtKB/Swiss-Prot
      G3V137, Q8WVI1, Q8WWR9
      Related
      ENSP00000304926.8, ENST00000303202.8
      Conserved Domains (1) summary
      pfam15060
      Location:1 → 69
      PPDFL; Differentiation and proliferation regulator

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      49054336..49076093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      49432165..49453922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WWR9.1 GenPept UniProtKB/Swiss-Prot:Q8WWR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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