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    GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [ Homo sapiens (human) ]

    Gene ID: 2618, updated on 3-Nov-2024

    Summary

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    Official Symbol
    GARTprovided by HGNC
    Official Full Name
    phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseprovided by HGNC
    Primary source
    HGNC:HGNC:4163
    See related
    Ensembl:ENSG00000159131 MIM:138440; AllianceGenome:HGNC:4163
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIRS; GARS; PAIS; PGFT; PRGS; GARTF
    Summary
    The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 13.5), lymph node (RPKM 11.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GART in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (33503931..33542893, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (31885765..31924746, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34876238..34915198, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene RPS5 pseudogene 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene basic transcription factor 3 pseudogene 6 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:34903402-34904601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13260 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:34914753-34915484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13261 Neighboring gene SON DNA and RNA binding protein Neighboring gene microRNA 6501 Neighboring gene DNA replication fork stabilization factor DONSON Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:34960679-34961178

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase. Connelly S, et al. Biochemistry, 2013 Jul 30. PMID 23869564, Free PMC Article
    2. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Zhang Y, et al. Biochemistry, 2003 May 27. PMID 12755606
    3. The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase. Dahms TE, et al. Biochemistry, 2005 Jul 26. PMID 16026156
    4. Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes. Manieri W, et al. Biochemistry, 2007 Jan 9. PMID 17198385, Free PMC Article
    5. Phylogenetic analysis and in silico characterization of the GARS-AIRS-GART gene which codes for a tri-functional enzyme protein involved in de novo purine biosynthesis. Banerjee D, et al. Mol Biotechnol, 2009 Jul. PMID 19301155

    See all (160) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GART Functions as a Novel Methyltransferase in the RUVBL1/beta-Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer.
      Title: GART Functions as a Novel Methyltransferase in the RUVBL1/β-Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer.
    2. VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression.
      Title: VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression.
    3. The transcriptome profile of human trisomy 21 blood cells.
      Title: The transcriptome profile of human trisomy 21 blood cells.
    4. GART expression is up-regulated in patients with active colitis.
      Title: GART mediates the renewal of intestinal epithelial barrier via p38/p53/PUMA cascade in colitis.
    5. The minor A allele of rs7279549 of GART is a functional risk factor for congenital heart disease in Shandong population.
      Title: Association of genetic polymorphisms of de novo nucleotide biosynthesis with increased CHD susceptibility in the northern Chinese population.
    6. most significant association was detected for GART rs8971. Compared with individuals with the TT genotype, the age- and sex-adjusted odds ratio (OR) for developing HCC was 1.44 (95% confidence interval (CI): 1.03-2.02) among those with the CC genotype
      Title: Genetic variations in the one-carbon metabolism pathway genes and susceptibility to hepatocellular carcinoma risk: a case-control study.
    7. The current results showed that GART expression was associated with glioma grade and that high GART protein expression might be related to poor outcome.
      Title: Glycinamide ribonucleotide formyl transferase is frequently overexpressed in glioma and critically regulates the proliferation of glioma cells.
    8. our clinical and in vitro data indicate that GART expression may be one of the causative factors for a poor prognosis in hepatocellular carcinoma.
      Title: Increased expression of glycinamide ribonucleotide transformylase is associated with a poor prognosis in hepatocellular carcinoma, and it promotes liver cancer cell proliferation.
    9. High-resolution structural data for GART (transformylase domain; purN) reveal new binding mode for lipophilic diastereoisomer inhibitors of GART, folate analogs with anti-leukemic activity.
      Title: Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase.
    10. Using the SNaPshot assay, evidence presented for allelic nondisjunction at rs363506 in the GRIK1 gene and rs2834235 and rs7283354 in the GARS-AIRS-GART gene in Down syndrome in India.
      Title: SNaPshot Assay in Quantitative Detection of Allelic Nondisjunction in Down Syndrome.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of GART PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif interacts with GART; interaction predicted to be relevant to purine pyrimidine biosynthesis PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC47764

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity TAS
    Traceable Author Statement
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylformylglycinamidine cyclo-ligase activity TAS
    Traceable Author Statement
    more info
    		  
    enables phosphoribosylglycinamide formyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylglycinamide formyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 'de novo' IMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' XMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brainstem development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine ribonucleoside monophosphate biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    trifunctional purine biosynthetic protein adenosine-3
    Names
    GAR transformylase
    GARS-AIRS-GART
    glycinamide ribonucleotide formyltransferase
    glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase
    NP_000810.1
    NP_001129477.1
    NP_001129478.1
    NP_780294.1
    XP_005260998.1
    XP_006724052.1
    XP_006724053.1
    XP_011527828.1
    XP_047296699.1
    XP_054180407.1
    XP_054180408.1
    XP_054180409.1
    XP_054180410.1
    XP_054180411.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029160.2 RefSeqGene

      Range
      5776..43960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000819.5 → NP_000810.1  trifunctional purine biosynthetic protein adenosine-3 isoform 1

      See identical proteins and their annotated locations for NP_000810.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Variants 1, 3, and 4 encode the same protein.
      Source sequence(s)
      AK292897, BQ010035, DB236855, X54199
      Consensus CDS
      CCDS13627.1
      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
      UniProtKB/TrEMBL
      Q3B7A7
      Related
      ENSP00000371236.4, ENST00000381815.9
      Conserved Domains (7) summary
      cd02196
      Location:469 → 767
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:809 → 991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK05385
      Location:435 → 766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      TIGR00877
      Location:4 → 426
      purD; phosphoribosylamine--glycine ligase
      pfam01071
      Location:105 → 298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334 → 424
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    2. NM_001136005.1 → NP_001129477.1  trifunctional purine biosynthetic protein adenosine-3 isoform 1

      See identical proteins and their annotated locations for NP_001129477.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a different segment for its 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same protein.
      Source sequence(s)
      AK292560, AK292897, BM172468, BQ010035
      Consensus CDS
      CCDS13627.1
      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
      UniProtKB/TrEMBL
      Q3B7A7
      Related
      ENSP00000371253.3, ENST00000381831.7
      Conserved Domains (7) summary
      cd02196
      Location:469 → 767
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:809 → 991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK05385
      Location:435 → 766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      TIGR00877
      Location:4 → 426
      purD; phosphoribosylamine--glycine ligase
      pfam01071
      Location:105 → 298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334 → 424
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    3. NM_001136006.1 → NP_001129478.1  trifunctional purine biosynthetic protein adenosine-3 isoform 1

      See identical proteins and their annotated locations for NP_001129478.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains a different segment for its 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same protein.
      Source sequence(s)
      AB208785, AK292897, BQ010035, DB062974
      Consensus CDS
      CCDS13627.1
      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
      UniProtKB/TrEMBL
      Q3B7A7
      Related
      ENSP00000371261.3, ENST00000381839.7
      Conserved Domains (7) summary
      cd02196
      Location:469 → 767
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:809 → 991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK05385
      Location:435 → 766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      TIGR00877
      Location:4 → 426
      purD; phosphoribosylamine--glycine ligase
      pfam01071
      Location:105 → 298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334 → 424
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    4. NM_175085.3 → NP_780294.1  trifunctional purine biosynthetic protein adenosine-3 isoform 2

      See identical proteins and their annotated locations for NP_780294.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing 3' end exons, compared to variant 1, which results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      BC038958, BQ477393, DB236855
      Consensus CDS
      CCDS13628.1
      UniProtKB/TrEMBL
      Q15374
      Related
      ENSP00000354388.5, ENST00000361093.9
      Conserved Domains (4) summary
      TIGR00877
      Location:4 → 426
      purD; phosphoribosylamine--glycine ligase
      pfam01071
      Location:105 → 298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334 → 424
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      33503931..33542893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440743.1 → XP_047296699.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77

    2. XM_006723990.3 → XP_006724053.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      See identical proteins and their annotated locations for XP_006724053.1

      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
      UniProtKB/TrEMBL
      Q3B7A7
      Conserved Domains (7) summary
      cd02196
      Location:469 → 767
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:809 → 991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK05385
      Location:435 → 766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      TIGR00877
      Location:4 → 426
      purD; phosphoribosylamine--glycine ligase
      pfam01071
      Location:105 → 298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334 → 424
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    3. XM_011529526.3 → XP_011527828.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      See identical proteins and their annotated locations for XP_011527828.1

      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
      UniProtKB/TrEMBL
      Q3B7A7
      Conserved Domains (7) summary
      cd02196
      Location:469 → 767
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:809 → 991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK05385
      Location:435 → 766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      TIGR00877
      Location:4 → 426
      purD; phosphoribosylamine--glycine ligase
      pfam01071
      Location:105 → 298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334 → 424
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    4. XM_006723989.3 → XP_006724052.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      See identical proteins and their annotated locations for XP_006724052.1

      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
      UniProtKB/TrEMBL
      Q3B7A7
      Conserved Domains (7) summary
      cd02196
      Location:469 → 767
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:809 → 991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK05385
      Location:435 → 766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      TIGR00877
      Location:4 → 426
      purD; phosphoribosylamine--glycine ligase
      pfam01071
      Location:105 → 298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334 → 424
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    5. XM_005260941.3 → XP_005260998.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      See identical proteins and their annotated locations for XP_005260998.1

      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
      UniProtKB/TrEMBL
      Q3B7A7
      Conserved Domains (7) summary
      cd02196
      Location:469 → 767
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:809 → 991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK05385
      Location:435 → 766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      TIGR00877
      Location:4 → 426
      purD; phosphoribosylamine--glycine ligase
      pfam01071
      Location:105 → 298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334 → 424
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315970.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      108061..115588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      31885765..31924746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324432.1 → XP_054180407.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77

    2. XM_054324433.1 → XP_054180408.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77

    3. XM_054324434.1 → XP_054180409.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77

    4. XM_054324436.1 → XP_054180411.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77

    5. XM_054324435.1 → XP_054180410.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22102.1 GenPept UniProtKB/Swiss-Prot:P22102

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