FDCSP follicular dendritic cell secreted protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: FDCSPprovided by HGNC
Official Full Name: follicular dendritic cell secreted proteinprovided by HGNC
Primary source: HGNC:HGNC:19215
See related: Ensembl:ENSG00000181617 MIM:607241; AllianceGenome:HGNC:19215
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C4orf7; FDC-SP
Summary: This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011]
Expression: Biased expression in salivary gland (RPKM 447.2), lymph node (RPKM 235.7) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 4q13.3; 4q13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (70226124..70235252)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (73565445..73574935)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (71091841..71100969)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These studies show that TNF-alpha stimulates human FDC-SP gene transcription by targeting YY1, GATA, C/EBP2 and C/EBP3 in the FDC-SP gene promoter.
Title: Tumor necrosis factor-α regulates human follicular dendritic cell-secreted protein gene transcription in gingival epithelial cells.
LPS-induced upregulation of FDC-SP expression in human periodontal ligament cells may enhance osteoclastogenesis in periodontal disease.
Title: Follicular dendritic cell-secreted protein may enhance osteoclastogenesis in periodontal disease.
FDC-SP may be involved in IgA production in the tonsils of Immunoglobulin A nephropathy patients.
Title: Decreased expression of follicular dendritic cell-secreted protein correlates with increased immunoglobulin A production in the tonsils of individuals with immunoglobulin A nephropathy.
FDC-SP overexpression inhibits osteogenic differentiation of hPDLCs. study contributes to a better understanding of biological functions governing FDC-SP-induced hPDLC differentiation.
Title: Osteogenic differentiation of human periodontal ligament cells after transfection with recombinant lentiviral vector containing follicular dendritic cell secreted protein.
Our findings demonstrate that transfection with FDC-SP has negligible adverse effect on proliferation of hPDLCs and imply the biological function of FDC-SP as a fibroblastic phenotype stabilizer
Title: Transfection with follicular dendritic cell secreted protein to affect phenotype expression of human periodontal ligament cells.
The role of C4orf7 in ovarian cancer cell morphology, motility and invasion was demonstrated.
Title: C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion.
These results provide the first evidence for immunomodulatory activities of FDC-SP and implicate this molecule as a regulator of B cell responses.
Title: Follicular dendritic cell secreted protein (FDC-SP) regulates germinal center and antibody responses.
FDC-SP has a very restricted tissue distribution, expressed by activated FDCs from tonsils and TNF-alpha-activated FDC-like cell lines, but not by B cell lines, primary germinal center B cells, or anti-CD40 plus IL-4-activated B cells.
Title: FDC-SP, a novel secreted protein expressed by follicular dendritic cells.
Since only normal tissue was examined, these findings suggest that FDC-SP plays an important but previously unsuspected role within oral connective tissue.
Title: Identification of genes preferentially expressed in periodontal ligament: specific expression of a novel secreted protein, FDC-SP.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: follicular dendritic cell secreted peptide

Names: FDC secreted protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152997.4 → NP_694542.1 follicular dendritic cell secreted peptide precursor

See identical proteins and their annotated locations for NP_694542.1

Status: REVIEWED

Source sequence(s)

AY190326

Consensus CDS

CCDS3537.1

UniProtKB/Swiss-Prot

Q8NFU4

UniProtKB/TrEMBL

Q540F3

Related

ENSP00000318437.5, ENST00000317987.6

Conserved Domains (1) summary

pfam15215
Location:18 → 82

FDC-SP; Follicular dendritic cell secreted peptide