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    DLGAP3 DLG associated protein 3 [ Homo sapiens (human) ]

    Gene ID: 58512, updated on 27-Nov-2024

    Summary

    Official Symbol
    DLGAP3provided by HGNC
    Official Full Name
    DLG associated protein 3provided by HGNC
    Primary source
    HGNC:HGNC:30368
    See related
    Ensembl:ENSG00000116544 MIM:611413; AllianceGenome:HGNC:30368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAP3; SAPAP3; SPAPA3
    Summary
    Predicted to enable PDZ domain binding activity; molecular adaptor activity; and scaffold protein binding activity. Predicted to be involved in protein-containing complex assembly. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including cholinergic synapse; glutamatergic synapse; and neuromuscular junction. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 6.5) and testis (RPKM 1.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DLGAP3 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (34865436..34929650, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (34728067..34792309, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (35331037..35395251, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr1:35259863-35260017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 716 Neighboring gene gap junction protein alpha 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:35307996-35308683 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:35312807-35313492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:35319252-35320122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 719 Neighboring gene small integral membrane protein 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:35350327-35351322 Neighboring gene MPRA-validated peak171 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 634 Neighboring gene G protein-coupled receptor 199, pseudogene Neighboring gene transmembrane protein 35B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in modification of postsynaptic structure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cholinergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    disks large-associated protein 3
    Names
    DAP-3
    PSD-95/SAP90-binding protein 3
    SAP90/PSD-95-associated protein 3
    discs large homolog associated protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080418.3NP_001073887.1  disks large-associated protein 3

      See identical proteins and their annotated locations for NP_001073887.1

      Status: VALIDATED

      Source sequence(s)
      AC114490, AL122010
      Consensus CDS
      CCDS30670.1
      UniProtKB/Swiss-Prot
      O95886, Q5TDD5, Q9H3X7
      Related
      ENSP00000362444.1, ENST00000373347.6
      Conserved Domains (1) summary
      pfam03359
      Location:628979
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      34865436..34929650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541879.3XP_011540181.1  disks large-associated protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011540181.1

      UniProtKB/Swiss-Prot
      O95886, Q5TDD5, Q9H3X7
      Conserved Domains (1) summary
      pfam03359
      Location:628979
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    2. XM_047426631.1XP_047282587.1  disks large-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      O95886, Q5TDD5, Q9H3X7
    3. XM_011541880.3XP_011540182.1  disks large-associated protein 3 isoform X2

      Conserved Domains (1) summary
      pfam03359
      Location:131482
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      34728067..34792309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338001.1XP_054193976.1  disks large-associated protein 3 isoform X1

    2. XM_054338002.1XP_054193977.1  disks large-associated protein 3 isoform X2