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    CCT3 chaperonin containing TCP1 subunit 3 [ Homo sapiens (human) ]

    Gene ID: 7203, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CCT3provided by HGNC
    Official Full Name
    chaperonin containing TCP1 subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:1616
    See related
    Ensembl:ENSG00000163468 MIM:600114; AllianceGenome:HGNC:1616
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCTG; PIG48; TRIC5; CCT-gamma; TCP-1-gamma
    Summary
    The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in testis (RPKM 72.7), adrenal (RPKM 56.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CCT3 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156308968..156338292, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155447437..155476903, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156278759..156308083, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156271210-156271710 Neighboring gene MPRA-validated peak424 silencer Neighboring gene glycosylated lysosomal membrane protein Neighboring gene VHL like Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156297025-156297871 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156297872-156298717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1859 Neighboring gene TSSK6 activating cochaperone Neighboring gene Rh family B glycoprotein Neighboring gene Sharpr-MPRA regulatory region 198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156362688-156363193 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156369951-156370626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156371301-156371974 Neighboring gene MIR9-1 host gene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156382372-156382872 Neighboring gene microRNA 9-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma. Huang J, et al. BMC Cancer, 2023 Mar 14. PMID 36918801, Free PMC Article
    2. Dysfunction of CCT3-associated network signals for the critical state during progression of hepatocellular carcinoma. Wang J, et al. Biochim Biophys Acta Mol Basis Dis, 2024 Apr. PMID 38360074
    3. Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells. Zhang Y, et al. Cancer Lett, 2016 Mar 1. PMID 26739059
    4. Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma. Wang K, et al. BMC Mol Cell Biol, 2022 Jun 30. PMID 35773623, Free PMC Article
    5. Identification of CCT3 as a prognostic factor and correlates with cell survival and invasion of head and neck squamous cell carcinoma. Wang Y, et al. Biosci Rep, 2021 Oct 29. PMID 34505628, Free PMC Article

    See all (346) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysfunction of CCT3-associated network signals for the critical state during progression of hepatocellular carcinoma.
      Title: Dysfunction of CCT3-associated network signals for the critical state during progression of hepatocellular carcinoma.
    2. Circular RNA CCT3 is a unique molecular marker in bladder cancer.
      Title: Circular RNA CCT3 is a unique molecular marker in bladder cancer.
    3. m[6]A-modification regulated circ-CCT3 acts as the sponge of miR-378a-3p to promote hepatocellular carcinoma progression.
      Title: m(6)A-modification regulated circ-CCT3 acts as the sponge of miR-378a-3p to promote hepatocellular carcinoma progression.
    4. Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma.
      Title: Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma.
    5. Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma.
      Title: Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma.
    6. Chaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway.
      Title: Chaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway.
    7. Identification of CCT3 as a prognostic factor and correlates with cell survival and invasion of head and neck squamous cell carcinoma.
      Title: Identification of CCT3 as a prognostic factor and correlates with cell survival and invasion of head and neck squamous cell carcinoma.
    8. Upregulation of CCT3 promotes cervical cancer progression through FN1.
      Title: Upregulation of CCT3 promotes cervical cancer progression through FN1.
    9. CCT3 suppression prompts apoptotic machinery through oxidative stress and energy deprivation in breast and prostate cancers.
      Title: CCT3 suppression prompts apoptotic machinery through oxidative stress and energy deprivation in breast and prostate cancers.
    10. High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma.
      Title: High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog
    Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif interacts with CCT3 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chaperone mediated protein folding independent of cofactor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of establishment of protein localization to telomere IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to Cajal body HMP PubMed 
    involved_in positive regulation of telomerase RNA localization to Cajal body HMP PubMed 
    acts_upstream_of positive regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chaperonin-containing T-complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of chaperonin-containing T-complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of zona pellucida receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-complex protein 1 subunit gamma
    Names
    T-complex protein 1, gamma subunit
    TCP1 (t-complex-1) ring complex, polypeptide 5
    chaperonin containing T-complex polypeptide 1 subunit 3
    chaperonin containing TCP1, subunit 3 (gamma)
    hTRiC5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008800.3 → NP_001008800.1  T-complex protein 1 subunit gamma isoform c

      See identical proteins and their annotated locations for NP_001008800.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform c), compared to isoform a.
      Source sequence(s)
      AK126400, AK293477, BG476176
      Consensus CDS
      CCDS30888.1
      UniProtKB/TrEMBL
      Q2TU64
      Related
      ENSP00000357242.2, ENST00000368259.6
      Conserved Domains (2) summary
      cd03337
      Location:6 → 487
      TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      TIGR02344
      Location:6 → 491
      chap_CCT_gamma; T-complex protein 1, gamma subunit

    2. NM_005998.5 → NP_005989.3  T-complex protein 1 subunit gamma isoform a

      See identical proteins and their annotated locations for NP_005989.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AB208882, AK126400, BG476176
      Consensus CDS
      CCDS1140.2
      UniProtKB/Swiss-Prot
      A6NE14, P49368, Q5SZY1, Q9BR64
      UniProtKB/TrEMBL
      Q2TU64
      Related
      ENSP00000295688.3, ENST00000295688.8
      Conserved Domains (1) summary
      TIGR02344
      Location:6 → 529
      chap_CCT_gamma; T-complex protein 1, gamma subunit

    RNA

    1. NR_036564.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK126400, AK300765, BG476176
      Related
      ENST00000368262.7

    2. NR_036565.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK126400, AK316387, BG476176
      Related
      ENST00000472765.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156308968..156338292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155447437..155476903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008883.1: Suppressed sequence

      Description
      NM_001008883.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49368.4 GenPept UniProtKB/Swiss-Prot:P49368

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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