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    TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 [ Homo sapiens (human) ]

    Gene ID: 7073, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TIAL1provided by HGNC
    Official Full Name
    TIA1 cytotoxic granule associated RNA binding protein like 1provided by HGNC
    Primary source
    HGNC:HGNC:11804
    See related
    Ensembl:ENSG00000151923 MIM:603413; AllianceGenome:HGNC:11804
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCBP; TIAR
    Summary
    The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 14.6), lymph node (RPKM 14.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TIAL1 in Genome Data Viewer
    Location:
    10q26.11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119573465..119596964, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (120471044..120494540, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121332977..121356476, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121150987-121151487 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:121160908-121162107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121164620-121165120 Neighboring gene microRNA 4681 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121203591-121204381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121210069-121210568 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121211884-121212060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121214023-121214544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121225296-121225796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4120 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:121239005-121239584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121269325-121269826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121269827-121270326 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121274963-121275176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121275942-121276524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2874 Neighboring gene regulator of G protein signaling 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4125 Neighboring gene NANOG hESC enhancer GRCh37_chr10:121303486-121303994 Neighboring gene uncharacterized LOC105378512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121355707-121356705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121356706-121357703 Neighboring gene Sharpr-MPRA regulatory region 3145 Neighboring gene MPRA-validated peak1112 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121396416-121396639 Neighboring gene RAD1 pseudogene 1 Neighboring gene ribosomal protein S8 pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and functional characterization of a TIA-1-related nucleolysin. Kawakami A, et al. Proc Natl Acad Sci U S A, 1992 Sep 15. PMID 1326761, Free PMC Article
    2. Translational repression by RNA-binding protein TIAR. Mazan-Mamczarz K, et al. Mol Cell Biol, 2006 Apr. PMID 16537914, Free PMC Article
    3. Novel DNA-binding properties of the RNA-binding protein TIAR. Suswam EA, et al. Nucleic Acids Res, 2005. PMID 16091628, Free PMC Article
    4. Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR. Kim HS, et al. Mol Cell Biol, 2007 Oct. PMID 17682065, Free PMC Article
    5. TIA proteins are necessary but not sufficient for the tissue-specific splicing of the myosin phosphatase targeting subunit 1. Shukla S, et al. J Biol Chem, 2004 Apr 2. PMID 14736875

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation.
      Title: RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation.
    2. Depletion of TIAR accelerates mitotic entry and leads to chromosomal instability in response to replication stress, in a manner that can be alleviated by the concomitant depletion of Cdc25B or inhibition of CDK1. Since TIAR retains CDK1 in GMGs and attenuates CDK1 activity, we propose that the assembly of GMGs may represent a so far unrecognized mechanism that contributes to the activation of the G2/M checkpoint
      Title: TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress.
    3. The manipulation of miR2233p/TIAL1 interaction may be involved in the neuroprotective effects of DEX.
      Title: miR‑223‑3p/TIAL1 interaction is involved in the mechanisms associated with the neuroprotective effects of dexmedetomidine on hippocampal neuronal cells in vitro.
    4. Data indicate that both ELAVL1 and TIAR positively regulate endogenous SNCA in vivo.
      Title: Discovering the 3' UTR-mediated regulation of alpha-synuclein.
    5. we identified MT1JP as a critical factor in restraining cell transformation by modulating p53 translation through interactions with TIAR
      Title: LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway.
    6. Data suggest that TPD52 (tumor protein D52) and a TPD52 fragment (residues 78-280) along with TIA-1 (T-cell intracellular antigen-1) and TIAR (TIA-1-related protein) contribute to mRNA stability as cis-acting and trans-acting factors; 3prime-untranslated regions of TPD52, TPD53, and TPD54 regulate expression of their respective genes in a post-transcriptional manner by altering mRNA stability.
      Title: Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability.
    7. results suggest that TIA-1 and TIAR are two new host factors that interact with 5-UTR of EV71 genome and positively regulate viral replication
      Title: TIA-1 and TIAR interact with 5'-UTR of enterovirus 71 genome and facilitate viral replication.
    8. TIAL1 inhibition of the exon 8 exclusion led to a decrease in SIRT1-Exon8 mRNA levels.
      Title: HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.
    9. TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells.
      Title: Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression.
    10. A role for TIAR is identified in T-cells for control of translational specificity.
      Title: Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag co-localizes and interacts with G3BP1 and TIAR to modulate stress granule assembly during HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33401

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR AU-rich region binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-RNA adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in germ cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of miRNA-mediated gene silencing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in stem cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytolytic granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in lysosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleolysin TIAR
    Names
    T-cluster binding protein
    TIA-1-related nucleolysin
    TIA1 related
    aging-associated gene 7 protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029240.1 RefSeqGene

      Range
      5066..28565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001033925.2 → NP_001029097.1  nucleolysin TIAR isoform 2

      See identical proteins and their annotated locations for NP_001029097.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a longer protein (isoform 2).
      Source sequence(s)
      AA972022, AC012468, AK125264, BC030025, M96954
      Consensus CDS
      CCDS31295.1
      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
      Related
      ENSP00000358089.2, ENST00000369093.6
      Conserved Domains (3) summary
      cd12620
      Location:222 → 294
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12616
      Location:10 → 107
      RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:113 → 192
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

    2. NM_001323964.2 → NP_001310893.1  nucleolysin TIAR isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform 3.
      Source sequence(s)
      AC012468, BC030025
      UniProtKB/TrEMBL
      Q49AS9
      Conserved Domains (2) summary
      cd12620
      Location:82 → 154
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:2 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001323965.2 → NP_001310894.1  nucleolysin TIAR isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform 3.
      Source sequence(s)
      AC012468
      UniProtKB/TrEMBL
      Q49AS9
      Conserved Domains (2) summary
      cd12620
      Location:82 → 154
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:2 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001323967.2 → NP_001310896.1  nucleolysin TIAR isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform 3.
      Source sequence(s)
      AC012468
      UniProtKB/TrEMBL
      Q49AS9
      Conserved Domains (2) summary
      cd12620
      Location:82 → 154
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:2 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_001323968.2 → NP_001310897.1  nucleolysin TIAR isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC012468
      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2

    6. NM_001323969.2 → NP_001310898.1  nucleolysin TIAR isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC012468
      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
      Conserved Domains (3) summary
      cd12620
      Location:166 → 238
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:57 → 136
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:1 → 51
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. NM_001323970.2 → NP_001310899.1  nucleolysin TIAR isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC012468, BC128140
      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
      Conserved Domains (3) summary
      cd12620
      Location:183 → 255
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:74 → 153
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:19 → 68
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. NM_003252.4 → NP_003243.1  nucleolysin TIAR isoform 1

      See identical proteins and their annotated locations for NP_003243.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AA972022, AC012468, AK125264, AL833106, BC030025
      Consensus CDS
      CCDS7613.1
      UniProtKB/Swiss-Prot
      A8K3T0, A8K4L9, Q01085
      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
      Related
      ENSP00000394902.2, ENST00000436547.7
      Conserved Domains (3) summary
      cd12620
      Location:205 → 277
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12616
      Location:10 → 90
      RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:96 → 175
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

    RNA

    1. NR_136661.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012468, AL833106

    2. NR_136662.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012468

    3. NR_136663.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012468, D64015

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      119573465..119596964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448151.2 → XP_024303919.1  nucleolysin TIAR isoform X1

      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
      Conserved Domains (3) summary
      cd12620
      Location:183 → 255
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:74 → 153
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:19 → 68
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_047425698.1 → XP_047281654.1  nucleolysin TIAR isoform X1

    3. XM_047425699.1 → XP_047281655.1  nucleolysin TIAR isoform X1

    4. XM_047425701.1 → XP_047281657.1  nucleolysin TIAR isoform X2

    RNA

    1. XR_001747194.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      120471044..120494540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366667.1 → XP_054222642.1  nucleolysin TIAR isoform X1

    2. XM_054366665.1 → XP_054222640.1  nucleolysin TIAR isoform X1

    3. XM_054366666.1 → XP_054222641.1  nucleolysin TIAR isoform X1

    4. XM_054366669.1 → XP_054222644.1  nucleolysin TIAR isoform X2

    5. XM_054366668.1 → XP_054222643.1  nucleolysin TIAR isoform X2

    RNA

    1. XR_008488259.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_022333.1: Suppressed sequence

      Description
      NM_022333.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01085.1 GenPept UniProtKB/Swiss-Prot:Q01085

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