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    ZDHHC22 zinc finger DHHC-type palmitoyltransferase 22 [ Homo sapiens (human) ]

    Gene ID: 283576, updated on 27-Nov-2024

    Summary

    Official Symbol
    ZDHHC22provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 22provided by HGNC
    Primary source
    HGNC:HGNC:20106
    See related
    Ensembl:ENSG00000177108 AllianceGenome:HGNC:20106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C14orf59
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in protein localization to plasma membrane and protein palmitoylation. Located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward brain (RPKM 10.2) See more
    Orthologs
    NEW
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    Genomic context

    See ZDHHC22 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (77131270..77142288, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (71341038..71352076, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77597613..77608134, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77564243-77565072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8791 Neighboring gene CLOCK interacting pacemaker Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8793 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8795 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77600131-77600630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77605838-77606387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77606525-77607088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77607089-77607652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77607747-77608248 Neighboring gene Sharpr-MPRA regulatory region 385 Neighboring gene family with sequence similarity 204 member D, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8796 Neighboring gene transmembrane protein 63C Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77666368-77666882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8797

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC22
    Names
    DHHC-22
    putative palmitoyltransferase ZDHHC22
    zinc finger DHHC domain-containing protein 22
    zinc finger DHHC-type containing 22
    zinc finger, DHHC domain containing 22
    NP_001351101.1
    NP_777636.2
    XP_011534963.1
    XP_054231858.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364172.1NP_001351101.1  palmitoyltransferase ZDHHC22

      Status: VALIDATED

      Source sequence(s)
      AC007375
      Consensus CDS
      CCDS45140.1
      UniProtKB/Swiss-Prot
      A6NH02, B7Z2L5, Q149P4, Q8N966
      Conserved Domains (1) summary
      pfam01529
      Location:92218
      DHHC; DHHC palmitoyltransferase
    2. NM_174976.2NP_777636.2  palmitoyltransferase ZDHHC22

      See identical proteins and their annotated locations for NP_777636.2

      Status: VALIDATED

      Source sequence(s)
      AC007375, BC117676, DA496626
      Consensus CDS
      CCDS45140.1
      UniProtKB/Swiss-Prot
      A6NH02, B7Z2L5, Q149P4, Q8N966
      Related
      ENSP00000318222.4, ENST00000319374.4
      Conserved Domains (1) summary
      pfam01529
      Location:92218
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      77131270..77142288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536661.3XP_011534963.1  palmitoyltransferase ZDHHC22 isoform X1

      See identical proteins and their annotated locations for XP_011534963.1

      UniProtKB/Swiss-Prot
      A6NH02, B7Z2L5, Q149P4, Q8N966
      Conserved Domains (1) summary
      pfam01529
      Location:92218
      DHHC; DHHC palmitoyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      71341038..71352076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375883.1XP_054231858.1  palmitoyltransferase ZDHHC22 isoform X1

      UniProtKB/Swiss-Prot
      A6NH02, B7Z2L5, Q149P4, Q8N966